Serum fetuin A/α2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: Relation with liver fibrosis
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Date
2010-11
Authors
Yılmaz, Yusuf
Yönal, Oya
Kurt, Ramazan
Çelikel, Çiğdem Ataizi
Özdoğan, Osman Cavit
İmeryüz, Neşe
Avşar, Erol
Kalaycı, Cem
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications
Abstract
Background: Serum concentrations of fetuin A/alpha 2HS-glycoprotein (AHSG) have been linked to human metabolic alterations and can serve as an indicator of liver cell function. We assayed serum levels of AHSG in patients with non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, and examined their association with clinical, biochemical and histological phenotypes.
Methods: Serum AHSG levels were determined by enzyme linked immunosorbent assay in 99 patients with biopsy-proven NAFLD and 75 age- and gender-matched controls.
Results: Serum AHSG levels were significantly higher in patients with NAFLD (940 +/- 120 mu g/mL) compared with healthy controls (800 +/- 130 mu g/mL, Student's t test, P < 0.001). Bivariate analyses (Spearman's rank correlation) in patients with NAFLD showed a statistically significant association between AHSG levels and insulin resistance as assessed by the HOMA (homeostasis model assessment) index (r = 0.31, P < 0.01) and the liver fibrosis score index (r = 0.36, P < 0.001). The association between AHSG and fibrosis remained statistically significant even after adjustment for potential confounders, including the HOMA index ([beta] = 1.65, t = 2.38, P < 0.05).
Conclusion: Serum AHSG levels are significantly increased in adult patients with biopsy-proven NAFLD and are associated with insulin resistance. Importantly, our pilot data indicate that serum AHSG levels may identify NAFLD patients with higher fibrosis scores.
Description
Keywords
Chronic kidney-disease, Insulin-resistance, Metabolic syndrome, Association, Obesity, Glycoprotein/fetuin, Antagonist, Mechanisms, Protein, Biopsy, Medical laboratory technology
Citation
Yılmaz, Y. vd. (2010). "Serum fetuin A/α2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: Relation with liver fibrosis". Annals of Clinical Biochemistry, 47(Part 6), 549-553.