Deneysel olarak travmatik beyin hasarı oluşturulan ratlarda serum pNF-H düzeyinin beyin hasarını göstermede etkinliği
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Date
2021-06-15
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Bursa Uludağ Üniversitesi
Abstract
Çalışmamızın amacı deneysel olarak hafif travmatik beyin hasarı oluşturulan sıçanlardan alınan serum örneklerinde pNF-H düzeyinin hasarı göstermede etkin olup olmadığını araştırmaktır. Marmarou modelinin modifiye edilerek kullanıldığı deneysel çalışmamızda farklı yüksekliklerden farklı ağırlıklarda bilyeler serbest düşme yöntemiyle bırakılarak sırayla 0.05, 0.1, 0.2 ve 0.4 Newton şiddetinde travma oluşturulması hedeflendi. Travmanın indüksiyonundan 2 saat sonra sıçanların kalbinden alınan kanlarda pNF-H düzeyi araştırıldı. Sonuç olarak deneysel olarak hafif travmatik beyin hasarı oluşturduğumuz ratlarda 2.saatte alınan kanlarda pNF-H düzeylerindeki değişiklikler istatistiksel olarak anlamlı bulunmamıştır. Bu sonuçlar hafif travmatik beyin hasarından sonraki 2.saatte kanda çalışılan pNF-H’ın tanısal olarak etkin olmadığını göstermektedir.
The aim of our study is to investigate whether pNF-H level is effective in demonstrating traumatic brain injury in serum samples taken from rats with experimental traumatic brain injury. In our experimental study where the Marmarou model was modified and used, it was aimed to create trauma with the intensity of 0.05, 0.1, 0.2 and 0.4 Newton respectively by using balls of different weights from different heights with free fall method. The pNF-H level was investigated in the blood taken from the heart of rats 2 hours after the induction of trauma. As a result, the changes in pNF-H levels in the blood taken at the 2nd hour from rats with experimental traumatic brain injury were not found to be statistically significant. These results show that pNF-H, which is studied in the blood in the second hour after traumatic brain injury, is not diagnostically effective.
The aim of our study is to investigate whether pNF-H level is effective in demonstrating traumatic brain injury in serum samples taken from rats with experimental traumatic brain injury. In our experimental study where the Marmarou model was modified and used, it was aimed to create trauma with the intensity of 0.05, 0.1, 0.2 and 0.4 Newton respectively by using balls of different weights from different heights with free fall method. The pNF-H level was investigated in the blood taken from the heart of rats 2 hours after the induction of trauma. As a result, the changes in pNF-H levels in the blood taken at the 2nd hour from rats with experimental traumatic brain injury were not found to be statistically significant. These results show that pNF-H, which is studied in the blood in the second hour after traumatic brain injury, is not diagnostically effective.
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Keywords
pNF-H, Kafa travması, Acil servis, Emergency department, Traumatic brain injury
Citation
Çıkrıklar, H. İ. vd. (2021). ''Deneysel olarak travmatik beyin hasarı oluşturulan ratlarda serum pNF-H düzeyinin beyin hasarını göstermede etkinliği''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 47(2), 195-199.