İsofluran ve propofolün bazı lenfosit subgruplar ve hematolojik parametreler üzerine olan etkilerinin incelenmesi
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Date
2000
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Uludağ Üniversitesi
Abstract
Çalışmamızda minör cerrahi uygulanan 30 olguda, bir inhalasyon anesteziği olan isofluran ile bir intravenöz anesiezik olan propofolün bazı lenfasit subgrupları ve hematolojik parametreler üzerine olan etkilerini araştırmayı amaçladık. 18-60 yaş arasında ASA (Amerikan Anesteziyoloji Derneği) I grubu hastalar rastgele iki gruba ayrıldılar. İndüksiyon ajanı olarak birinci grup olgulara % 2.5'lik tiyopental 4 mg/kg iv ve ikinci grup olgulara % 1 'lik propofol 2.5 mg/kg iv verildi. Anestezi idamesi I. grupta % 50 N2O/O2 ve % 0.75'lik isofluran gaz karışımı ile, II. grupta % 50 N2O/O2 gaz karışımına ek olarak 6 ,ug/kg/st hızda propofol infüzyonu ile sağlandı. Her iki grupta da kas gevşetici ajan olarak vekuronyum bromür ve analjezik ajan olarak fentanil kullanıldı. İndüksiyondan önce ve operasyonun 90.dakikasında periferik venöz kandan alınan örneklerde lökosit, trombosit, hemoglobin değerleri; periferik kan yaymalarında lenfosit, nötrofil, monosit, eozinofil değerleri; lenfasit subgrupları (CD3, CD4, CD8, CD16, CD20, CD25, HLA DR) değerleri incelendi. lndüksiyondan önce ve operasyonun 90. dakikasında elde edilen değerler karşılaştırıldığında; I. grupta CD4 düzeyinde anlamlı bir artma, ll. grupta ise CD8 düzeyinde anlamlı bir azalma kaydedilirken, diğer parametrelerde bir farklılık saptanmadı. Sonuç olarak kullanılan her iki ajanın da immün sistemi baskılamadığı kanısına varıldı.
In this study the effects of isoflurane and propofol on hematologic parameters and same lymphocyte subgrubs were compared in 30 patients undergoing minor surgery. ASA (American Society of Anesthesiologists) I patients aged between 18-60 years were randomly divided into two groups. The anesthesia was induced by 2.5 % thiopentone 4 mg/kg iv in the first group and by 1 % propofol 2.5 mg/kg iv in the second group. Anesthesia was maintained by 0.75 % isoflurane 50 % N2O/O1 gas mixture in the first group and by 50 % N2O/O2 gas mixture and propofol infusion at the rate of 6 ,ug/kg/hr in the second group. In both groups vecuronium were used as muscle relaxant agent and fentanyl were used as analgesic agent. Before the induction and at the 90 minutes of the operation peripheric venous blood were taken from the patients to investigate the leucocyte, platelet and hemoglobin levels; lymphocyte, neutrocyte, monocyte, eosinophil levels by the peripheric blood count and lymphocyte subgrubs (CD3, CD4, CD8, CD16, CD20, CD25 and HLA DR). When we compare the values of preinduction with the values of the 90 minutes of operation, there was an increase in CD4 level in the first group and a decrease in CD8 level in the second group and no change in the other parameters. We conclude that both agents do not suppress the immunologic response.
In this study the effects of isoflurane and propofol on hematologic parameters and same lymphocyte subgrubs were compared in 30 patients undergoing minor surgery. ASA (American Society of Anesthesiologists) I patients aged between 18-60 years were randomly divided into two groups. The anesthesia was induced by 2.5 % thiopentone 4 mg/kg iv in the first group and by 1 % propofol 2.5 mg/kg iv in the second group. Anesthesia was maintained by 0.75 % isoflurane 50 % N2O/O1 gas mixture in the first group and by 50 % N2O/O2 gas mixture and propofol infusion at the rate of 6 ,ug/kg/hr in the second group. In both groups vecuronium were used as muscle relaxant agent and fentanyl were used as analgesic agent. Before the induction and at the 90 minutes of the operation peripheric venous blood were taken from the patients to investigate the leucocyte, platelet and hemoglobin levels; lymphocyte, neutrocyte, monocyte, eosinophil levels by the peripheric blood count and lymphocyte subgrubs (CD3, CD4, CD8, CD16, CD20, CD25 and HLA DR). When we compare the values of preinduction with the values of the 90 minutes of operation, there was an increase in CD4 level in the first group and a decrease in CD8 level in the second group and no change in the other parameters. We conclude that both agents do not suppress the immunologic response.
Description
Bu çalışma, 1997 tarihinde Bursa[Türkiye]’da düzenlenen XXXI. Türk Anesteziyoloji ve Reanimasyon Kongresi‘nde bildiri olarak sunulmuştur.
Keywords
İsofluran, Propofol, İmmün yanıt, Isoflurane, Immune response
Citation
Moğol, E. B. vd. (2000). "İsofluran ve propofolün bazı lenfosit subgruplar ve hematolojik parametreler üzerine olan etkilerinin incelenmesi". Uludağ Üniversitesi Tıp Fakültesi Dergisi, 26(3), 101-106.