Üremili olgularda fosfor bağlayıcıların sekonder hiperparatiroidi'ye etkileri
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Date
1997-01-27
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Uludağ Üniversitesi
Abstract
Hemodiyaliz ünitemizdeki 60 hasta çalışma kapsamına alındı. 20' şer kişilik üç gruba ayrılan hastaların 1. grubuna 4 gr/gün Alüminyum Hidroksit (AI(OH), 2. grubuna 3 gr/gün Kalsiyum Karbonat (CaC03 ) ve 3. grubuna 5 gr/gün Kalsiyum Asetat ( (CH2 COO)2Ca ) oral yoldan üç ay süreyle verildi. Gruplar tedavi öncesi ve sonrası ortalama serum kalsiyum, fosfor, iyonize kalsiyum, alkali fosfataz ve intakt paratiroid hormon (iPTH) düzeylerinde istatistiki yönden anlamlı fark saptanmadı. Serum alüminyum düzeyi ise AI(OH)3 alan grupta anlamlı olarak arttı. (p < 0. 001). Sonuç olarak kalsiyumlu bileşiklerin alüminyumlu bileşikler kadar fosforu bağlayabildikleri ve serum alüminyum düzeyini etkilemeden güvenle kullanılabilecekleri söylenebilir.
Sixty patients have been included in our study in our Hemodialysis unit. These patients have been classifıecl into three groups consisting of 20 patients each. The first group has been given Aluminium Hydroxide (A I(OH3 )) 4 gr/day, the second group calcium carbonate (CaCO3) 3 gr/day and the third group calcium acetate (CH2 COO)2 Ca) 5 gr/day orally for a period of three months. Vo statistically significant differences have been found in pre or post treatment mean levels of serum calcium, phosphorus, ionized calcium, alkaline phosphatase and intact parathyroid. However, senını aluminium levels has increased significantly in the group receiving AI(OH)3 (p < 0. 001). As a result, it may be said that calcium compounds can bind phosphorus as much as aluminium compounds can and that they can be administered safely without affecting serum aluminium level.
Sixty patients have been included in our study in our Hemodialysis unit. These patients have been classifıecl into three groups consisting of 20 patients each. The first group has been given Aluminium Hydroxide (A I(OH3 )) 4 gr/day, the second group calcium carbonate (CaCO3) 3 gr/day and the third group calcium acetate (CH2 COO)2 Ca) 5 gr/day orally for a period of three months. Vo statistically significant differences have been found in pre or post treatment mean levels of serum calcium, phosphorus, ionized calcium, alkaline phosphatase and intact parathyroid. However, senını aluminium levels has increased significantly in the group receiving AI(OH)3 (p < 0. 001). As a result, it may be said that calcium compounds can bind phosphorus as much as aluminium compounds can and that they can be administered safely without affecting serum aluminium level.
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Keywords
Üremi, Sekonder hiperparatiroidi, Fosfor bağlayıcılar, Uremia, Secondary hyperparathyroid, Phosphor bioders
Citation
Yavuz, M. vd. (1996). ''Üremili olgularda fosfor bağlayıcıların sekonder hiperparatiroidi'ye etkileri''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 23(1-2-3), 5-19.