Kobaylarda deriye uygulanan "krom oksit"in böbrekler üzerine etkisi
Loading...
Files
Date
1992
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Krom (Cr) organizma için esansiyel bir elementtir. Ama fazla alındığında toksik etkileri görülebilir. Özellikle deride aşırı duyarlılık reaksiyonIarına yol açan Cr, deriden emilime uğrayıp, sistemik etkilerde gösterebilir. Bu araştırma, derisine krom oksit (CrO3) uygulanan (n =25) ve uygulanmayan (n =25) kobay gruplan üzerinde gerçekleştirildi. 21 gün CrO3 uygulandıktan sonra, tüm kobayların serumlarında böbrek işlevlerini gösteren bazı biyokimyasal parametreler (üre, kreatinin, sodyum, potasyum klorür, kalsiyum, fosfor vb.) ölçüldü. Sonra glukoz ve üre ile bu parametrelerin korelasyon ile araştırıldı. Sonuçta, deriden absorbe olan kromun özellikle kan glukozu ve insülin üzerindeki etkilerine ikincil, bu parametrelerde değişimlere yol açtığı kanısına varıldı. Kromun böbrek üzerindeki zararlı etkilerinin ise minimal düzeyde olduğu gözlendi.
Chromium (Cr) is an essential element for the organism, but when it is uptaken more than needed, toxic effects of it can be seen. Cr causes 'hypersensitivity reactions in the skin, particularly. In addition to this, it can be absorbed through the skin and result in systemic effects. This investigation is performed on guinea pigs, which were divided into two groups respectively as the control group (n =25) and the chromium oxide ( CrO3) applied group (n = 25 ). After the application of Cr03 for 21 days, in all the sera of these guinea pigs, some parameters (urea, creatinine, sodium, potassium, chloride, calcium and phosphorus etc.) indicating the kidney functions are measured.Then the core- locations of these parameters with serum glucose and urea are investigated. In the result, we have obtained the idea that Cr, particularly affecting the blood glucose and insülin levels in serum, caused variations in the parameters mentioned above. While the harmful effects of Cr on the kidneys are observed to be minimum.
Chromium (Cr) is an essential element for the organism, but when it is uptaken more than needed, toxic effects of it can be seen. Cr causes 'hypersensitivity reactions in the skin, particularly. In addition to this, it can be absorbed through the skin and result in systemic effects. This investigation is performed on guinea pigs, which were divided into two groups respectively as the control group (n =25) and the chromium oxide ( CrO3) applied group (n = 25 ). After the application of Cr03 for 21 days, in all the sera of these guinea pigs, some parameters (urea, creatinine, sodium, potassium, chloride, calcium and phosphorus etc.) indicating the kidney functions are measured.Then the core- locations of these parameters with serum glucose and urea are investigated. In the result, we have obtained the idea that Cr, particularly affecting the blood glucose and insülin levels in serum, caused variations in the parameters mentioned above. While the harmful effects of Cr on the kidneys are observed to be minimum.
Description
Keywords
Krom oksit, Böbrekler, Kidneys, Chromium oxide, Guinea pigs, Kobaylar
Citation
Güler, A. H. vd. (1992). ''Kobaylarda deriye uygulanan "krom oksit"in böbrekler üzerine etkisi''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 19(3), 299-308.