Short and long term effects of granulocyte colony-stimulating factor during induction therapy in acute myeloid leukemia patients younger than 65: Results of a randomized multicenter phase III trial
Date
2011-03
Authors
Beksaç, Meral
Özcan, Muhit
Özçebe, Osman
Bayık, Mahmut
Paydaş, Semra
Büyükaşık, Yahya
İlhan, Osman
Gürman, Günhan
Uysal, Akın
Akan, Hamdi
Journal Title
Journal ISSN
Volume Title
Publisher
Pergamon-Elsevier Science
Abstract
This prospective multicenter phase III clinical trial was designed to assess efficacy and safety of G-CSF as an adjunct to de novo AML remission induction therapy (www.clinicaltrials.gov.NCT00820976). Patients' characteristics were similar in both arms. G-CSF improved severity and duration of leukopenia. Three-year OS were similar (25.6 +/- 5.1% vs. 31.8 +/- 5.6%) in both arms except for patients with myeloblastic features. Significant factors for better survival were the use of G-CSF (p = 0.049), female sex (p = 0.05) and single induction cycle (p < 0.001) in multivariate analysis. Female patients performed better than male patients. Better survival obtained among female AML patients needs to be validated within the context of cytogenetic analysis.
Description
Keywords
Oncology, Hematology, Granulocyte colony-stimulating factor, Acute myeloid leukemia, Induction, Survival, Acute myelogenous leukemia, Placebo-controlled trial, Southwest-oncology-group, Elderly-patients, Double-blind, Adult patients, Growth-factors, G-csf, Febrile neutropenia, Prognostic-factors
Citation
Beksaç, M. vd. (2011). "Short and long term effects of granulocyte colony-stimulating factor during induction therapy in acute myeloid leukemia patients younger than 65: Results of a randomized multicenter phase III trial". Leukemia Research, 35(3), 340-345.