The similarity between aspirin treatment and the lack of response to epinephrine and the frequency of aspirin resistance in healthy males
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Date
2011-04
Authors
Sağdilek, Engin
Korkmaz, Ahmet
Öter, Şükrü
Avcu, Ferit
Topal, Turgut
Özler, Mehmet
Uysal, Bülent
Nevruz, Oral
Beyan, Cengiz
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications
Abstract
Objectives: The lack of response of platelets against epinephrine has been discovered with a frequency of 14% to 40% in previous studies. There are studies that have demonstrated the effect of aspirin on platelets may resemble the lack of response to epinephrine. In this study, the extent of the effects of aspirin treatment on aggregation and secretion in healthy males with a lack of response to epinephrine and the frequency of aspirin resistance were investigated. Methods: Blood samples were collected at the beginning and at the end of a 10-day aspirin usage in 52 healthy males. Epinephrine, adenosine diphosphate (ADP), collagen, arachidonic acid (AA) and thrombin aggregations, and adenosine triphosphate (ATP) secretion were studied. Participants were assigned to nonresponder (< 20%), semiresponder (20%-60%), and responder (> 60%) groups, depending on their maximum aggregation responses to epinephrine. Participants who displayed an aggregation to AA at the end of the aspirin treatment were accepted to be aspirin resistant. Results: Of the 52 participants, 4 were found to be nonresponders and 3 of 52 of the participants were found to be semiresponders. Although the lack of response to epinephrine and aspirin treatment displayed similarities in aggregations using epinephrine, ADP, collagen, and thrombin, they differed in aggregations using AA and for ATP secretion. The ratio of aspirin resistance was determined to be 4:52. Conclusions: The observation of AA aggregation in the participants with a lack of response to epinephrine demonstrates that epinephrine nonresponse cannot substitute aspirin treatment. The fact that aspirin resistance is observed in healthy males supports the view that aspirin resistance exists even before the first usage.
Description
Bu çalışma, 05-07 Mayıs 2006 tarihleri arasında İzmir[Türkiye]’da düzenlenen 6. National Congress of Thrombosis, Haemostasis and Angiology’da bildiri olarak sunulmuştur.
Keywords
Hematology, Cardiovascular system & cardiology, Platelets, Optical aggregometer, Epinephrine, Aspirin resistance, Platelet-function, In-vitro, Responsiveness, Prevalence, Disease, Drugs
Citation
Sağdilek, E. vd. (2011). "The similarity between aspirin treatment and the lack of response to epinephrine and the frequency of aspirin resistance in healthy males". Clinical and Applied Thrombosis-Hemostasis, 17(2), 202-207.