Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy
Date
2002-11-15
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott Williams & Wilkins
Abstract
We aimed to investigate the possible convulsant action of arginine vasopressin (AVP) in both a febrile convulsion model in rat pups and a temporal lobe epilepsy model in adult rats and to define the receptor type which mediates this effect. In rat pups, 125 ng V-2 receptor antagonist significantly prevented hyperthermic seizures, but did not affect seizure latency. In adult rats, the only effective dose and agent was 125 ng V-2 receptor antagonist, which prevented pilocarpine-induced status epilepticus, extended the status epilepticus latency and improved the 24 h survival rate. These data suggest that AVP has a convulsant activity in febrile convulsions and also in seizures independent of fever, and this effect is mediated by V-2 receptors.
Description
Keywords
Neurosciences & neurology, Arginine vasopressin, Convulsant, Rat, Receptor, Seizure, Central-nervous-system, Acid-induced seizures, Oxytocin, Release, Rats, Neurosciences & neurology
Citation
Güleç, G. ve Noyan, B. (2002). "Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy". Neuroreport, 13(16), 2045-2048.