Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline
Loading...
Date
2001-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Assoc Bras Divulg Cientifica
Abstract
In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 μg) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 μg, icv), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 μg, icv), was administered 3 rain before choline. Twenty-five μg captopril did not block the pressor effect of choline, while 50 μg captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats.
Description
Keywords
Blood pressure, Captopril, Choline, Intracerebroventricular choline, Spontaneously hypertensive rats, Renin-angiotensin system, Conscious rabbits, Normotensive rats, Brain, Hemorrhage, Stimulation, Carbachol, Drinking, Life sciences & biomedicine - other topics, Research & experimental medicine
Citation
İşbil, B. N. vd. (2001). "Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline". Brazilian Journal of Medical and Biological Research, 34(6), 815-820.