Effect of misoprostol on acute cisplatin nephrotoxicity
Date
1999
Authors
Antypas, G.
Journal Title
Journal ISSN
Volume Title
Publisher
Medimond S R L
Abstract
Protective effects of misoprostol on non steroidal antiinflammatory drugs (NSAIDs) and cyclosporine nephrotoxicity is well described in the literature, but the role of misoprostol in cisplatin nephrotoxicity is not fully understood. In our study, we planned to investigate the protective effect of misoprostol in acute cisplatin nephrotoxicity. Our patient group consisted 28 patient with lung cancer. All patients received cisplatin + etoposide chemotherapy regimen. The patients were divided into two groups. Misoprostol Group (14 patients); was given misoprostol 100 mu g qid (po) during chemotherapy. Control Group (14 patients); only received chemotherapy. Glomerular and proximal tubular functions were measured in both groups before the onset of chemotherapy and on the 2(nd) and 6(th) days of chemotherapy. As a result of our study, we have not been able to show the protective effect of misoprostol in tubular and glomerular functional disturbances due to cisplatin administration.
Description
Bu çalışma, 10-14 Eylül 1998 tarihleri arasında İzmir[Türkiye]'de düzenlenen 2nd Congress of the Balkan-Union-of-Oncology'de bildiri olarak sunulmuştur.
Keywords
Oncology, Prostaglandin-e1 analog misoprostol, Renal-function, Cyclosporine nephrotoxicity, Oral misoprostol, Indomethacin Cells, Protection, Cirrhosis, Kidneys, Injury, Cells
Citation
Kurt, E. vd. (1999). "Effect of misoprostol on acute cisplatin nephrotoxicity". ed. G Antypas. 2nd Balkan Congress of Oncology, 401-406.