Neuroproctective effects of ischemic tolerance (preconditioning) and postconditioning

Date

2009-10

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Türk Nöroşirürji Derneği

Abstract

Elucidation of the endogenous cell survival pathways involved in ischemic tolerance (preconditioning) and postconditioning has significant clinical implications for preventing neuronal damage in susceptible patients. Ischemic tolerance is a phenomenon in which the brain protects itself against future injury by adapting to low doses of noxious insults. Ischemic postconditioning is defined as brief periods of reperfusion alternating with re-occlusion applied during the very early minutes of reperfusion that mechanically alters the hydrodynamics of reperfusion. Similar pathways and molecules play a role in pre-and postconditioning but their roles and timing are different in each conditioning. Understanding the neuroprotective effects of mechanisms underlying conditionings has been elusive, but NNMA receptor activation, nitric oxide, inflammatory cytokines, and suppression of the innate immune system appear to have a role. Reactive oxygen species and classical ligand stimuli play a role in postconditioning with KATP channels and protein kinase C pathways acting as mediators.

Description

Keywords

Neuronal protection, Postconditioning, Preconditioning, Focal cerebral-ischemia, Spreading depression, Nitric-oxide, Protein-synthesis, Neuronal damage, Rapid tolerance, Cytochrome-c, Injury, Stroke, Hypothermia, Neurosciences & neurology, Surgery

Citation

Alkan, T. (2009). "Neuroproctective effects of ischemic tolerance (preconditioning) and postconditioning". Turkish Neurosurgery, 19(4), 406-412.