Colistimethate sodium therapy for multidrug-resistant isolates in pediatric patients
Date
2010-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Aim:
The aim of the present study was to assess the efficacy and safety of colistimethate sodium therapy in multidrug-resistant nosocomial infections caused by Pseudomonas aeruginosa or Acinetobacter baumannii in neonates and children.
Methods:
Pediatric patients hospitalized at the Uludag University Hospital who had nosocomial infections caused by multidrug-resistant P. aeruginosa or A. baumannii, were enrolled in the study. Colistimethate sodium at a dosage of 50-75 x 103 U/kg per day was given i.v. divided into three doses.
Results:
Fifteen patients received 17 courses of colistimethate sodium for the following infections: ventilator-associated pneumonia (n = 14), catheter-related sepsis (n = 1) and skin and soft-tissue infection (n = 2). The mean age of patients was 53.2 + 74.7 months (range, 8 days-15 years) and 60% were male. Mortality was 26.6%.
Conclusion:
Colistimethate sodium appears to be safe and effective for the treatment of severe infections caused by multidrug-resistant P. aeruginosa or A. baumannii in pediatric patients.
Description
Keywords
Acinetobacter baumannii, Children, Colistimethate sodium, Nosocomial infection, Pseudomonas aeruginosa, Ventilator-associated pneumonia, Intensive-care-unit, Pseudomonas-aeruginosa, Intravenous colistin, Nosocomial infections, Risk-factors, Acinetobacter, Pediatrics
Citation
Çelebi, S. vd. (2010). "Colistimethate sodium therapy for multidrug-resistant isolates in pediatric patients". Pediatrics International, 52(3), 410-414.