Kainic acid activates oxytocinergic neurons through non-NMDA glutamate receptors
Date
2006
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
The present study assessed if kainic acid activates oxytocinergic neurons and this activation is blocked by 6- cyano- 7- nitroquinoxaline- 2,3- dione ( CNQX). Dual immunohistochemistry for oxytocin and c- Fos showed that oxytocin neurons in SON and PVN express c- Fos following kainic acid administration, a significant increase when compared to the control group. Administration of CNQX prior to kainic acid caused a significant reduction. The results suggested the participation of non- NMDA receptors in the regulation of oxytocin neurons because the administration of kainic acid activates these neurons and this activation is blocked by CNQX administration.
Description
Keywords
Neurosciences & neurology, SON, PVN, Oxytocin, Kainate, Immunohistochemistry, CNQX, Expression, In-vitro, Lactating rat, Synaptic currents, Magnocellular neurons, Supraoptic nucleus, Rat hypothalamus, Subunit messenger-rnas, Hypothalamic paraventricular nucleus, Methyl-D-aspartate
Citation
Minbay, F. Z. vd. (2006). ''Kainic acid activates oxytocinergic neurons through non-NMDA glutamate receptors''. International Journal of Neuroscience, 116(5), 587-600.