Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: Impact on homocysteine and folic acid status and reference intervals
Date
2009-12
Authors
Sucu, Derya Kaynak
Aslan, Diler
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Methylenetetrahydrofolate reductase (MTHFR) is important for folate and homocysteine (Hcy) metabolism. MTHFR 677C->T and 1298A->C MTHFR are two most common mutations which can affect. folate and total homocysteine (tHcy) status This study was designed to determine the rate of,MTHFR 677C->T and 1298A->C mutations. and their Influence Oil serum folate, Hcy and vitamin B12 Status and the reference intervals in 402 healthy Turkish adults. The rate of MTHFR 677C->T or 1298A->C mutations was 50 7% or 54 7%. respectively. The MTHFR 677C->T mutation-specific reference intervals for serum folate and tHcy were characterized by marked shifts in their upper limits In homozygote subjects for MTHFR 677C->T serum folate concentration was lower and serum tHcy concentration was higher than those in the wild genotype. all subjects had lower serum folate and 54% of the subjects had higher tHcy concentration,; than the cutoff Values of <= 10 nmol/L and >= 12 mu mol/L, respectively. Serum vitamin 1312 status was similar in all genotypes Serum tHcy concentrations were inversely correlated with serum folate and vitamin B12 concentrations in all genotypes These data show that the rate of MTHFR 677C->T and 1298A->C mutations is very high in Turks and serum folate and tHcy status are impaired by these mutations.
Description
Keywords
Folate, Homocysteine, MTHFR, Mutations, Reference intervals, Turkey, Vitamin B12, Methylenetetrahydrofolate reductase gene, Approved recommendation 1987, Collected reference values, Coronary-artery-disease, 3rd national-health, Plasma homocysteine, Cardiovascular-disease, Common mutation, Risk-factor, Statistical treatment, Biochemistry & molecular biology, Cell biology
Citation
İlçöl, Y. Ö. vd. (2009). "Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: Impact on homocysteine and folic acid status and reference intervals". Cell Biochemistry and Function, 27(8), 568-577.