A case of epidermodysplasia verruciformis associated with squamous cell carcinoma and Bowen's disease: A therapeutic challenge
Date
2006
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
Epidermodysplasia verruciformis (EV) is a very rare and chronic disease characterized by a susceptibility to cutaneous infections by a group of phylogenetically related human papillomavirus (HPV) types. We present here a 52-year-old man previously diagnosed and treated as squamous cell carcinoma but also found to have epidermodysplasia verruciformis lesions in association with Bowen's disease. The patient was effectively treated with a combination of interferon therapy (6 million units, twice a week) and topical imiquimod for Bowen's disease (five times a week). We conclude that topical imiquimod is very effective in the treatment of Bowen's disease and may be combined with systemic interferon therapy in rare cases with multiple vivid presentations of HPV infections.
Description
Keywords
Dermatology, Squamous cell carcinoma, Interferon alpha, Imiquimod, Epidermodysplasia verruciformis, Bowen's disease, Human papillomaviruses, DNA, Imiquimod 5-percent cream, Acitretin, Immunodeficiency, Combination, Immunotherapy
Citation
Başkan, E. B. vd. (2006). ''A case of epidermodysplasia verruciformis associated with squamous cell carcinoma and Bowen's disease: A therapeutic challenge''. Journal of Dermatological Treatment, 17(3), 179-183.