Serum tiroglobulin düzeylerinin tiroid glandının sintigrafik bulguları ile ilişkisi
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Date
1992
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Uludağ Üniversitesi
Abstract
136 diffüz guatr, 100 nodüler guatr, 29 subtotal tiroidektomi, 10 suprese tiroid ve 46 normal olguda serum tiroglobulin (TG) düzeyleri RIA ile ölçüldü. 136 diffüz guatr olgusu Dünya Sağlık Örgütünün (WHO) önerdiği kriterlerle değerlendirildi ve 87 olguda I. derecede, 35 olguda ll. derece, 14 olguda lll. derece guatr tanısı kondu. Sintigrafik çalışmada 100 nodüler guatr olgusundan 43'ünde hipoaktif multinodüler guatr, 31 inde hipoaktif soliter nodular guatr, 16'sında hiperaktif tek nodül ve 10 unda normoaktif tek nodül izlendi. TG düzeyleri yönünden gruplar arası farklılık araştırılmıştır. Diffüz guatr ile normal olgular ve nodüler guatr ile normal olgular arasında istatistiksel yönden anlamlı farklılık bulmuştur (p < 0.001). En yüksek ortalama TG düzeyi nodüler guatr grubunda bulmuştur (40.6 T 33 ng ml). Normal olgularıli TG düzeyi 12 T 10.3 ng/ml iken diffüz guatrlarda 23 + 20 ng/ml olarak saptanmıştır. Sintigrafide tiroid bezi vizualize edilmeyen 10 olgı m TG düzeyleri 38 T 20.3 ng/ml bulmuştur.
The senını TG levels were measured in 136 diffuse goitre, 100 nodular goitre, 29 subtotal tlıyroidectomy, 10 non visualise thyroid and 46 nonnal cases with radioimmunoassay method. 136 diffuse goitre patients were evahıated with the criterion of WHO and 87 of them had 1°, 35 of 136 had II? and 14 of them had lIIO diffuse goitre. With scintigraphic studies 100 nodular goitre (NG) were diagnosed as follows; 43 hypoactive multi NG, 31 hypoactive solitary NG, 16 hyperactive NG and 10 normoactive solitary NG. The differences between the groups were evaluated with student-t test and it was found that the difference between diffuse goitres and nonnals were statistically significant (p < 0.001). The highest mean serum TG levels were found in the nodular goitre group (40.6 T 33 g/nı/). While normal cases had shown mean TG levels 12 T 10.3 gn/ml, it was found 23 T 20 ng/ml in diffuse goitre, 10 cases had scintigraphically non-visualised thyroid and they had mean TG levels 38 + 20.3 ng/ml.
The senını TG levels were measured in 136 diffuse goitre, 100 nodular goitre, 29 subtotal tlıyroidectomy, 10 non visualise thyroid and 46 nonnal cases with radioimmunoassay method. 136 diffuse goitre patients were evahıated with the criterion of WHO and 87 of them had 1°, 35 of 136 had II? and 14 of them had lIIO diffuse goitre. With scintigraphic studies 100 nodular goitre (NG) were diagnosed as follows; 43 hypoactive multi NG, 31 hypoactive solitary NG, 16 hyperactive NG and 10 normoactive solitary NG. The differences between the groups were evaluated with student-t test and it was found that the difference between diffuse goitres and nonnals were statistically significant (p < 0.001). The highest mean serum TG levels were found in the nodular goitre group (40.6 T 33 g/nı/). While normal cases had shown mean TG levels 12 T 10.3 gn/ml, it was found 23 T 20 ng/ml in diffuse goitre, 10 cases had scintigraphically non-visualised thyroid and they had mean TG levels 38 + 20.3 ng/ml.
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Keywords
Serum tiroglobulin düzeyi, Tiroid, Glandı sintigrafik bulgular, Guatr, Diffüz guatr, Nodüler guatr
Citation
Güneş, İ. ve Sarıkaya, İ. (1992). ''Serum tiroglobulin düzeylerinin tiroid glandının sintigrafik bulguları ile ilişkisi''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 19(1), 49-54.