Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide

Date

2001-02-28

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier Science

Abstract

The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions. Rat pups were exposed to single or multiple hyperthermic seizures. Subconvulsant doses of pilocarpine (100 mg/kg and 150 mg/kg) were injected intraperitoneally to these rats at 60-70 days of age. Also L-arginine was applied to some rats before a single hyperthermic seizure. We found that risk of future epilepsy increases parallel to the number of febrile convulsions and nitric oxide does not have a pathogenetic role at given doses.

Description

Keywords

Pilocarpine, Rat, Seizure, Susceptibility, Resistant, Hyperthermia-induced seizures, Temporal-lobe epilepsy, Status epilepticus, Long-term, Rat susceptibility, Childhood, Glutamate, System

Citation

Güleç, G. ve Noyan, B. (2002). "Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide". Developmental Brain Research, 126(2), 223-228.