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Title: Basaloid squamous cell carcinoma of the larynx: A report of four new cases
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun ve Boğaz Hastalıkları Anabilim Dalı.
Erişen, Levent M.
Coşkun, Hakan H.
Özuysal, Sema
Basut, Oǧuz İbrahim
Onart, Selçuk
Hızalan, İbrahim
Tezel, İlker
Keywords: Research & experimental medicine
Laryngeal carcinoma
Basaloid squamous cell carcinoma
Issue Date: Jul-2004
Publisher: Wiley
Citation: Erişen, L.M. vd. (2004). “Basaloid squamous cell carcinoma of the larynx: A report of four new cases”. Laryngoscope, 114(7), 1179-1183.
Abstract: Objectives: This study is designed to report the clinical and pathologic features and outcome of cases of basaloid squamous cell carcinoma (BSCC) of the larynx treated in our clinic. Study Design: A retrospective review of the medical records of these patients. Methods: Four cases of BSCC of the larynx were treated in our department. Histopathologic slides were reevaluated to confirm the diagnosis. Immunohistochemical studies were performed, and file records were reviewed. Follow-up was available for all patients and ranged between 11 and 72 (mean 37) months. Results: All patients were male (mean 57), with supraglottic or transglottic larynx tumors. Two patients presented with stage-II disease and the other 2 with stage-IV disease. Initial diagnosis was invasive squamous cell carcinoma in 3 patients and BSCC in one patient. Two patients who had stage-II disease underwent partial laryngectomy and bilateral neck dissections; total laryngectomy and bilateral neck dissections were performed in stage-IV patients. Three patients received adjuvant postoperative radiotherapy, and 2 of them also received additional chemotherapy. Patients with stage-IV disease were found to have 4 and 27 metastatic lymph nodes on histopathologic examination and died because of distant metastases at 11 and 14 months, respectively. Patients with stage-II disease did not have cervical metastasis on histopathologic examination and were alive and free of disease at 52 and 72 months respectively. Conclusion: In contrast with the literature reporting the tendency of more aggressive clinical behavior of the BSCC, we can say that BSCC has a behavior similar to conventional squamous cell carcinoma based on our 4 cases.
Description: Bu çalışma, 29 Kasım-2 Aralık 2002 tarihleri arasında Brezilya'da düzenlenen Uluslararası Baş ve Boyun Onkolojisi Dernekleri Federasyonu 2. Dünya Kongresinde bildiri olarak sunulmuştur.
ISSN: 0023-852X
Appears in Collections:Scopus
Web of Science

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