Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus
Date
2000
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Acad Sciences Czech Republic Institute of Physiology
Abstract
The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats. Rats were implanted with chronic, stainless steel screw electrodes epidurally for electrocortical recordings. A control group received 3 mEq/kg LiCl (i.p.) and 24 h later 45 mg/kg pilocarpine HCl (i.p.). Two different experimental procedures were followed: (1) L-arginine was applied in doses of 100 mg/kg, 300 mg/kg or 500 mg/kg (i.p.), 30 min before pilocarpine injection; (2) 100 mg/kg, 500 mg/kg or 1000 mg/kg (i.p.) L-arginine was injected either 5 min or 30 min after the onset of status epilepticus (SE). L-arginine (300 mg/kg) injected 30 min before pilocarpine significantly reduced the percentage of SE, but did not change the latency to SE or 24-hour survival. These parameters were not significantly affected by the 100 mg/kg or 500 mg/kg dose of L-arginine. On the other hand, no dose of L-arginine that was applied after SE had begun, had any significant influence on the seizures. We concluded that L-arginine may prevent seizure activity in some but not all doses, and does not have any effect on the ongoing seizure activity.
Description
Keywords
Physiology, Nitric oxide, L-arginine, Status epilepticus, Rat, Nitric-oxide synthesis, Human temporal-lobe, Induced seizures, Brain-damage, Rats, Epilepsy, Model, Mechanisms, Acid, Mice
Citation
Noyan, B. ve Güleç, S. G. (2000). "Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus". Physiological Research, 49(3), 379-385.