Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26
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Date
2006
Authors
Kotenko, Sergei V.
Yılmaz, Mustafa
Mani, Orlando
Zumkehr, Judith
Blaser, Kurt
Akdiş, Cezmi A.
Akdiş, Mübeccel
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
The family of IL-10-related cytokines includes several human members, IL-19, IL-20, IL-22, IL-24 and IL-26, and a series of herpesviral and poxviral paralogs. Some of these cytokines share common receptor subunits. In this study, we investigated the effects of these cytokines on naive T cell differentiation, antigen-specific T cell suppression, survival and expression of surface markers in comparison to IL-10 and cytomegalovirus (CMV)-IL-10. Human CD45RA(+) T cells were stimulated in the presence of IL-10-family cytokines in sequential 12-day cycles. After three to four cycles of stimulation, IL-10 and CMV-IL-10 led to increased IFN-gamma and IL-10 but decreased IL-4 and IL-13. Interestingly, long-term exposure of T cells to IL-19, IL-20 and IL-22 down-regulated IFN-gamma but up-regulated IL-4 and IL-13 in T cells and supported the polarization of naive T cells toTh2-like cells. in contrast, neutralization of endogenous IL-22 activity by IL-22-binding protein decreased IL-4, IL-13 and IFN-gamma synthesis. The antigen-specific suppressor activity of IL-10 and CMV-IL-10 was not observed for any of the other IL-10-family cytokines. These data demonstrate that IL-19, IL-20 and IL-22 may participate in T cell-mediated diseases by distinct regulation of T cell cytokine profiles.
Description
Keywords
Immunology, T cells, New cytokines, Interleukin-10, Ifn-gamma, Type-1 cells, Stat activation, Receptor complexes, Melanoma differentiation, Differentiation-associated gene, Inducible factor, Cutting edge
Citation
Oral, H. B. vd. (2006). ''Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26''. European Journal of Immunology, 36(2), 380-388.