Centrally administered choline increases plasma prolactin levels in conscious rats
Date
1997-08-29
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Science Ireland
Abstract
Intracerebroventricular (i.c.v.) administration of choline, a precursor of acetylcholine (ACh) increased plasma prolactin levels in a time and dose-dependent manner in conscious rats. Pretreatment of rats with the cholinergic muscarinic antagonist, atropine (10 mu g, i.c.v.), blocked the increase in plasma prolactin level. The increase was not influenced by pretreatment with the cholinergic nicotinic antagonist, mecamylamine (50 mu g, i.c.v.). Pretreatment with hemicholinium-3 (HC-3; 20 mu g, i.c.v.), a high affinity choline uptake inhibitor, attenuated the choline-induced increase of plasma prolactin levels. These results show that choline increases plasma prolactin levels by activating muscarinic receptors via presynaptic mechanisms.
Description
Keywords
Neurosciences & neurology, Choline, Acetylcholine, Prolactin, Atropine, Mecamylamine, Hemicholinium-3, Acetylcholine-release, Injected choline, Corpus striatum, Invivo release, Enhancement
Citation
Gürün, M. S. vd. (1997). "Centrally administered choline increases plasma prolactin levels in conscious rats". Neuroscience Letters, 232(2), 79-82.