Spiküle meme kanserlerinin histopatolojik moleküler biyobelirteçler ve manyetik rezonans görüntüleme arasındaki korelasyonu
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Date
2020-04-17
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Bursa Uludağ Üniversitesi
Abstract
Bu çalışmanın amacı spiküle ve spiküle olmayan meme kanserinin MRG ve histopatolojik bulguları arasındaki ilişkiyi karşılaştırmaktır. Ocak 2014 ile Ocak 2018 arasında, mamografide BI-RADS kriterlerine göre 50 spiküle ve 40 spiküle olmayan kitle olarak ultrasonografi kılavuzluğunda biyopsi veya lumpektomi/mastektomi yapılan 90 kadın çalışmaya alındı. Meme kanserinin moleküler biyobelirteçlerini tanımlamak için östrojen reseptörü (ÖR), progesteron reseptörü (PR), HER2 ekspresyonu ve Ki67 indeksi kullanıldı. Korelasyonların istatistiksel önemini ölçmek için Pearson ki-kare testi yapıldı. İki grup arasında yaş açısından fark yoktu (p=0.331). Kitlelerin büyüklüğü iki grup arasında farklı değildi (p=0.244). Spiküle kitlelerde T2A görüntülerde (T2AG) daha fazla hipointens sinyal özelliği tespit edildi (p=0.004). MRG'de multifokal veya multisentrik tutulum, kitlesiz boyanma, periferik halkasal boyanma ve aksiller lenf nodu tutulumu açısından iki grup arasında fark yoktu (sırasıyla p=0.237, p=0.622, p=0.096, p=0.295 ve p=0.764). ÖR ve PR pozitifliği spiküle kitlelerde daha yüksekti (sırasıyla p=0.027 ve p=0.03). HER2 pozitifliği ve Ki67 indeksi için iki grup arasında istatistiksel olarak anlamlı bir fark bulunmadı (sırasıyla p=0.571 ve p=0.596).ÖR ve PR pozitifliği spiküle kitlelerde daha fazla olma eğilimindedir. Bu, hastalığın seyrini ve tedavinin etkinliğini tahmin etmede yardımcı olabilir.
To compare the relationship between MRI and histopathological findings of spiculated and non-spiculated breast cancer. Between January 2014 and January 2018, 90 women who had undergone ultrasonography guided biopsies or lumpectomy/mastectomy with 50 spiculated and 40 non-spiculated masses were separated accoding to BI-RADS criteria on mammography. Estrogen receptor (ER), progesterone receptor (PR), HER2 expression and Ki67 index were used as markers to identify molecular markers of breast cancer. Pearson chi-square test was employed to measure statistical significance of correlations. There was no difference for age between two groups (p=0.331). The size of the masses were not different between the two groups (p =0.244). More hypointense signal features were detected in T2-weighted images for the spiculated masses (p = 0.004). There was no difference between the two groups in terms of multifocal or multicentric involvement, non-mass type enhancement, peripheral rim enhancement and axillary lymph node involvement in the MRI (p=0.237, p=0.622, p=0.096, p=0.295 and p=0.764, respectively). ER and PR positivity were higher in the spiculated masses (p=0.027 and p=0.03, respectively). For the HER2 positivity and Ki67 index, statistically significant a difference were not found between two groups (p=0.571 and p=0.596, respectively). ER and PR positivity tends to be higher in the spiculated masses. This could be helpfull to predict the course of the disease as well as the effectiveness of the treatment.
To compare the relationship between MRI and histopathological findings of spiculated and non-spiculated breast cancer. Between January 2014 and January 2018, 90 women who had undergone ultrasonography guided biopsies or lumpectomy/mastectomy with 50 spiculated and 40 non-spiculated masses were separated accoding to BI-RADS criteria on mammography. Estrogen receptor (ER), progesterone receptor (PR), HER2 expression and Ki67 index were used as markers to identify molecular markers of breast cancer. Pearson chi-square test was employed to measure statistical significance of correlations. There was no difference for age between two groups (p=0.331). The size of the masses were not different between the two groups (p =0.244). More hypointense signal features were detected in T2-weighted images for the spiculated masses (p = 0.004). There was no difference between the two groups in terms of multifocal or multicentric involvement, non-mass type enhancement, peripheral rim enhancement and axillary lymph node involvement in the MRI (p=0.237, p=0.622, p=0.096, p=0.295 and p=0.764, respectively). ER and PR positivity were higher in the spiculated masses (p=0.027 and p=0.03, respectively). For the HER2 positivity and Ki67 index, statistically significant a difference were not found between two groups (p=0.571 and p=0.596, respectively). ER and PR positivity tends to be higher in the spiculated masses. This could be helpfull to predict the course of the disease as well as the effectiveness of the treatment.
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Keywords
Meme kanseri, Spikülasyon, MRG, Tümör belirteçleri, Breast cancer, Spiculation, MRI, Tumor receptor
Citation
Gökalp, G. (2020). ''Spiküle meme kanserlerinin histopatolojik moleküler biyobelirteçler ve manyetik rezonans görüntüleme arasındaki korelasyonu''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(1), 91-96.