Romatoid artritli hastalarda serum interleukin 1α düzeyleri ile insülin direnci arasındaki ilişki
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Date
2003-01-30
Authors
Top, Cihan
Cingözbay, Bekir Yılmaz
Keskin, Özcan
Tuncel, Altuğ
Önde, Mehmet Emin
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Dolaşımdaki normal düzeylerde insüline hedef hücrenin cevabında bozulma olarak tanımlanan insülin direnci, sık rastlanan patolojik bir durumdur. Sitokinlerin insülin duyarlılığı üzerindeki potansiyel etkileri yoğun araştırmalara konu olmuştur. Bu çalışmanın amacı, romatoid artritli hastalarda insülin direnci gibi glukoz metabolizma anormallikleri ile serum interleukin 1α düzeyleri arasındaki bağlantıyı araştırmaktır. Çalışmaya değişik derecelerde hastalık aktivitesine sahip romatoid artritli 36 hasta (22 kadın ve 14 erkek, ortalama yaş: 51.5 ±17.1 yıl (21-80 yaş arası), ortalama VKİ: 27.1±5.0 kg/m²) ve yaş, cinsiyet, VKİ olarak benzer özelliklere sahip 20 sağlıklı kontrol dahil edilmiştir. Açlık serum IL-1α ve insülin düzeyleri ölçüldü. İnsülin duyarlılığı HOMA yöntemiyle hesaplandı. Romatoid artritli hastalarda kontrollere oranla açlık serum insülin düzeyleri, HOMA skorları ve serum IL-1α düzeyleri anlamlı derecede yüksekti (14.7±6.7, 8.7±1.9 µIU/ml, p<0.001 ve 3.3±1.5, 1.9±0.5, p<0.001 ve 18.2±13.3, 13.0±2.4 pg/ml, p<0.01 sırasıyla). Tüm olgularda açlık insulin, HOMA-IR, IL-1α düzeyleri arasında bağlantı mevcuttu. Çalışmamızda, romatoid artritli hastalarda IL-1α regülasyonunun bozulduğunu, IL-1α ile insülin duyarlılığı arasında anlamlı derecede bağlantı bulunduğunu gözlemledik.
Insulin resistance is a common pathological state in which target cells fail to respond to ordinary levels of circulating insulin. The cytokines are the subject of intense research for potential effects on insulin sensitivity. The aim of our study was to evaluate the correlation of the changes in serum IL-1α levels with glucose metabolism abnormality, such as insulin resistance, in patients with rheumatoid arthritis. In this study, 36 subjects (22 women and 14 men, aged 51.5 ±17.1 years, ranging between 21-80, BMI 27.1±5.0 kg/m²) with varying degrees of disease activity and a control group of 20 healthy subjects matched by age, sex, and body mass index were evaluated. The fasting serum IL-1α and insulin levels were measured. HOMA–estimated insulin sensitivity was calculated. The fasting insulin levels, HOMA scores and serum IL-1α levels were significantly higher in all patients with rheumatoid artritis than in control subjects (14.7±6.7 vs. 8.7±1.9 µIU/ml, p<0.001 and 3.3±1.5 vs. 1.9±0.5, p<0.001 and 18.2±13.3 vs. 13.0±2.4 pg/ml, p<0.01 respectively). A correlation was found between the fasting insulin, HOMA-IR and IL-1α in the whole group. In our study, we showed that patients with rheumatoid arthritis have an altered IL-1α regulation, and there was a significant correlation between serum IL-1α levels and insülin sensitivity in patients with rheumatoid arthritis.
Insulin resistance is a common pathological state in which target cells fail to respond to ordinary levels of circulating insulin. The cytokines are the subject of intense research for potential effects on insulin sensitivity. The aim of our study was to evaluate the correlation of the changes in serum IL-1α levels with glucose metabolism abnormality, such as insulin resistance, in patients with rheumatoid arthritis. In this study, 36 subjects (22 women and 14 men, aged 51.5 ±17.1 years, ranging between 21-80, BMI 27.1±5.0 kg/m²) with varying degrees of disease activity and a control group of 20 healthy subjects matched by age, sex, and body mass index were evaluated. The fasting serum IL-1α and insulin levels were measured. HOMA–estimated insulin sensitivity was calculated. The fasting insulin levels, HOMA scores and serum IL-1α levels were significantly higher in all patients with rheumatoid artritis than in control subjects (14.7±6.7 vs. 8.7±1.9 µIU/ml, p<0.001 and 3.3±1.5 vs. 1.9±0.5, p<0.001 and 18.2±13.3 vs. 13.0±2.4 pg/ml, p<0.01 respectively). A correlation was found between the fasting insulin, HOMA-IR and IL-1α in the whole group. In our study, we showed that patients with rheumatoid arthritis have an altered IL-1α regulation, and there was a significant correlation between serum IL-1α levels and insülin sensitivity in patients with rheumatoid arthritis.
Description
Keywords
Romatoid artrit, Rheumatoid arthritis, İnsülin direnci, İnterleukin 1α, Insulin resistance, Interleukin 1α
Citation
Top, C. (2002). "Romatoid artritli hastalarda serum interleukin 1α düzeyleri ile insülin direnci arasındaki ilişki" Uludağ Üniversitesi Tıp Fakültesi Dergisi, 28(3),81-84.