Karotis aterosklerozu gelişmesinde etkili risk faktörleri
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Date
2003-04-15
Authors
Ertan, Nurcan Sönmez
Karşıdağ, Sibel
Duran, Cihan
Özer, Feriha
Arpacı, Baki
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
İskemik inme gelişiminde karotis stenozu önemli bir etyolojik faktördür. Bu çalışmada akut iskemik inme tanısı ile yatırılan 90 hastada karotis aterosklerozunun gelişiminde etkin risk faktörleri araştırılmıştır. Doppler ultrasonografide saptanan stenoz derecesine göre hastalar hafif stenoz grubu (stenoz derecesi< % 30), orta dereceli stenoz grubu (%30-69 arası), ağır stenoz grubu (> %70) olmak üzere üç gruba ayrılmıştır. Tek yönlü analizde, ağır stenoz grubunda yaş ortalamasının ve sigara kullanım oranının belirgin yüksek olduğu dikkat çekmiştir (sırasıyla p=0.02, p=0.001). Bu grubda, iskemik kalp hastalığı ve periferik arter hastalığı yüksek oranda saptanmıştır (sırasıyla p=0.05, p=0.02). Logistik regresyon analizinde ise sigara kullanımı ve iskemik kalp hastalığı ağır karotis stenozu gelişiminde bağımsız risk faktörü olarak belirlenmiştir. Karotis plaklarının ultrasonografik karakterleri araştırıldığı zaman, soft, heterojen plakların, ağır stenoz grubunda diğer grublara oranla daha fazla olduğu gözlenmiştir. Sonuç olarak sigara ve iskemik kalp hastalığı, karotis aterosklerozunun gelişmesinde bağımsız risk faktörü olarak görülmektedir.
Severe carotid stenosis has an importance in ischemic stroke development. In this study, effective risk factors in development of carotid atherosclerosis in acute stroke population are investigated. Patients were divided into three groups according to the degree of carotid stenosis: slight stenosis (<%30), medium stenosis (%30-69), severe stenosis (>%70). In univariate analysis, aging and smoking were found out as significant risk factors in carotid atherosclerosis development (respectively p=0.02, p=0.001). Ischemic heart disease and peripheral vascular disease were determined to have significant association with severe carotid stenosis (respectively p=0.05, p=0.02). When logistic regression analysis was used, smoking and ischemic heart disease were found to be significant independent determinants of severe carotid stenosis. When carotid plaque ultrasonic characterisation were investigated, soft, heterogenous plaques in severe stenosis group were found more than other groups. As a result, smoking and ischemic heart disease were seen to be important, independent risk factors in development of severe carotid atherosclerosis.
Severe carotid stenosis has an importance in ischemic stroke development. In this study, effective risk factors in development of carotid atherosclerosis in acute stroke population are investigated. Patients were divided into three groups according to the degree of carotid stenosis: slight stenosis (<%30), medium stenosis (%30-69), severe stenosis (>%70). In univariate analysis, aging and smoking were found out as significant risk factors in carotid atherosclerosis development (respectively p=0.02, p=0.001). Ischemic heart disease and peripheral vascular disease were determined to have significant association with severe carotid stenosis (respectively p=0.05, p=0.02). When logistic regression analysis was used, smoking and ischemic heart disease were found to be significant independent determinants of severe carotid stenosis. When carotid plaque ultrasonic characterisation were investigated, soft, heterogenous plaques in severe stenosis group were found more than other groups. As a result, smoking and ischemic heart disease were seen to be important, independent risk factors in development of severe carotid atherosclerosis.
Description
Keywords
Karotis, Ateroskleroz, Risk faktörleri, Carotis, Atherosclerosis, Risk factors
Citation
Ertan, N. S. vd. (2003). ''Karotis aterosklerozu gelişmesinde etkili risk faktörleri''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 29(1), 19-24.