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Title: Evaluation of clastogenicity of 4, 6-dinitro-o-cresol (DNOC) in allium root tip test
Authors: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
Aydemir, Nilüfer
Çelikler, Serap
Summak, Şenay
Yılmaz, Dilek
Özer, Özlem
Keywords: 4, 6-Dinitro-o-cresol (DNOC)
Allium test
Issue Date: 2008
Publisher: Uludağ Üniversitesi
Citation: Aydemir, N. vd. (2008). "Evaluation of clastogenicity of 4, 6-dinitro-o-cresol (DNOC) in allium root tip test". Journal of Biological and Environmental Sciences, 2(5), 59-63.
Abstract: 4, 6-Dinitro-o-cresol (DNOC) is a pesticide, fungicide and insecticide, used in agriculture. In this research the genotoxic effect of DNOC on the root tips of Allium cepa L. was determined. The correlations between the effects of different concentrations, exposure times on the mitotic index (MI) and induction of chromosomal aberrations (CA) were also examined. Experiments were carried out in duplicate, using aqueous solutions of DNOC to concentrations of 250 and 500 ppm, at intervals of 0, 3, 6, 12, and 24 h. The results revealed an inhibition of the MI at the highest concentration and experiment times; this is an evidence of cytotoxicity of DNOC. Large number of c-mitosis indicated that DNOC acts as a strong spindle inhibitor, whereas, other CA types such as, breaks, bridges etc. were found in all tested concentration and times (p < 0.001) showing that is a potent clastogen.
ISSN: 1307-9530
Appears in Collections:2008 Cilt 2 Sayı 5

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