2009 Cilt 3 Sayı 9
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Item Open Access Suspected succinylcholine poisoning in a German shepherd dog(Uludağ Üniversitesi, 2009) Oruç, Hasan Hüseyin; Akkoç, Ahmet; Alasonyalılar, Aylin; Aydın, Sami; Uludağ Üniversitesi/Veteriner Fakültesi.; Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.This report describes succinylcholine poisoning observed in a 4-year-old male, German shepherd dog. The dog was referred to Faculty of Veterinary Medicine, Uludag University in Bursa, Turkey for necropsy and toxicological investigation in February of 2008. The dog has died after muscular contractions and salivation in short time. An automatic injector was found on the right distal abdominal of the dog before death. Examining appropriate historical and clinical signs, pathologic and histopathologic findings with the dog and discovery of succinylcholine in a drop residue found in the automatic injector supported a diagnosis of succinylcholine poisoning.Item Open Access Anti-Aflatoxigenc potentials of two Nigerian herbs on albino rats(Uludağ Üniversitesi, 2009) Fapohunda, Stephen Oyedele; Akintewe, Tosin; Olarinmoye, Ayodefi; Ezekiel, Chinbudu NgoziThe anti-aflatoxigenic activity of methanolic and ethanolic extracts of Phyllanthus niruri and Pseudocedrella kotschyi were studied in male and female Wister albino rats fed with aflatoxin –contaminated chow (112ppb) for 20 d. Morbidity studies arising from the dietary aflatoxin were carried out. Packed Cell Volume (PCV), fasting blood sugar (FBS), haemoglobin concentration (HB), total white blood cells (WBC), and serum bilirubin (SB) were profiled.. Extracts from both herbs lowered the PCB, blood glucose, Hb, WBC and SB levels in the test male than in control at P<0.05 using the ANOVA test for significance. The ethanolic extracts of Pseudocedrella and the methanolic extract of Phyllanthus were the most effective anti-aflatoxigenic agents in the male as they reduced the blood parameter levels by 50% of the positive control. The results were not so in the females. Post-mortem examination revealed kidney discoloration and paleness, mild to moderate hepatomegaly and enlarged spleen in the positive control while test rats showed normal morphology for these organs. The 2 local herbs are good candidates for the management of aflatoxicosis in mammals.Item Open Access Propolis ameliorates human peripheral blood lymphocytes from DNA damage caused by Aflatoxin B1(Uludağ Üniversitesi, 2009) Türkez, Hasan; Yousef, Mokhtar I.Propolis, a natural product derived from plant resins collected by honeybees, has been used for thousands of years in traditional medicine all over the world. Its components are strong antioxidants and free radical scavengers. On the other hand, aflatoxin B1 (AFB1) is the most potent pulmonary and hepatic carcinogen. Since the eradication of AFB1 contamination in agricultural products has been difficult, the use of natural or synthetic free radical scavengers could be a potential chemopreventive strategy. The biological effects of propolis are known, but its interaction with AFB1 is not known for therapeutic uses. Therefore, this study was designed to examine the protective effects of different concentrations of propolis (6.25, 12.5, 25, 50 and 100 mg/L) against AFB1 (3.12 ppm) genotoxicity in human lymphocytes in vitro. The genotoxic effects were assessed by micronucleus (MN) test in human blood cultures. The results of the present study indicated that AFB1 significantly (P<0.05) increased formations of MNs in peripheral lymphocytes as compared to controls. On the contrary, propolis alone did not show genotoxic effects at the concentrations tested. Furthermore, AFB1-induced increases in the genotoxicity indices were diminished by the addition of propolis. This anti-mutagenic effect of propolis can be attributed to its powerful scavenger ability.Item Open Access Phytocontent screening of mucuna seeds and exploit in opposition to pathogenic microbes(Uludağ Üniversitesi, 2009) Kumor, Ashkok; Rajput, Gaurav; Dhatwalia, Vinod Kumar; Srivastav, GauravPlants and plant-based medicaments are the basis of many of the modern pharmaceuticals which we use today for our diverse ailments. The aim of the study was to find out the bio active chemical constituents and to evaluate the antimicrobial activity of the ethanolic extract and methanolic extract of herbal plant Mucuna pruriens and Mucuna bracteata. A qualitative phytocontent analysis was performed for the detection of alkaloids, glycosides, terpenoids, steroids, flavonoids, tannins, reducing sugar etc. All the plant extracts were subjected to individual microbiological tests to ascertain their antimicrobial activity against four pathogenic microorganisms: Salmonella typhi, Escherichia coli, Shigella dysenteriae and Bacillus subtilis. The antimicrobial activity of the extracts was determined by measuring the diameter of zone of inhibition (ZI) exhibited by the extracts. The extract of Mucuna pruriens was more effective against Escherichia coli (ZI = 2.8 cm) and less effective Bacillus subtilis (ZI= 2.1 cm). The extract of Mucuna bracteata was more effective against E. coli (ZI= 2.4 cm) and less against Salmonella typhi (ZI= 1.8 cm)Item Open Access A geometric description of the peritechia of the Pseudonectria rousseliana (Mont.) Wollenw(Uludağ Üniversitesi, 2009) Hüseyin, Elşad; Öztürk, Günay; Arslan, Kadri; Akgül, Hasan; Ergül, Cem; Bulca, Betül; Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Matematik Bölümü.; Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü.In this study, a geometric and experimental analysis of the peritechia of Pseudonectria rousseliana (Mont.) Wollen was presented. Experimentally, longitudinal length (A) and the body ( CD ) of peritechia were measured. Geometrically, it was shown that the peritechia is comparable with a surface of revolution of a profile curve. On the same regions of the modelled surface the diameters of the horizontal sections was measured. It was found that the geometric and the experimental values were closely related.