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The role of ADAMTS1 and versican in human myocardial infarction: A postmortem study

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dc.contributor.authorPehlivan, Sultan
dc.contributor.authorAkyol, Sümeyya
dc.contributor.authorEren, Filiz
dc.contributor.authorGüleç, Mehmet Akif
dc.contributor.authorEren, Bülent
dc.contributor.authorDemircan, Kadir
dc.contributor.authorAkyol, Ömer
dc.contributor.buuauthorGürses, Murat Serdar
dc.contributor.buuauthorUral, Mustafa Numan
dc.contributor.buuauthorİnanır, Nursel Türkmen
dc.contributor.buuauthorFedakar, Recep
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentAdli Tıp Ana Bilim Dalı
dc.contributor.orcid0000-0002-9982-0476
dc.contributor.orcid0000-0002-4047-6455
dc.contributor.researcheridAAH-6287-2021
dc.contributor.researcheridAAC-8913-2020
dc.contributor.scopusid55979536300
dc.contributor.scopusid57163358100
dc.contributor.scopusid57188706721
dc.contributor.scopusid8725968900
dc.date.accessioned2023-04-06T12:17:10Z
dc.date.available2023-04-06T12:17:10Z
dc.date.issued2016-08
dc.description.abstractObjective: To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI. Methods: Thirty autopsied individuals were allocated into 2 groups, namely, a study group of individuals who died of myocardial infarction (n = 20), and a control group who died of trauma (n = 10). We performed standard immunohistochemical staining on myocardial tissue specimens, studying anti-ADAMTS1, anti-versican, and anti-versican C terminal peptide sequence (DPEAAE) fragments. Results: Strong, diffuse staining was observed throughout myocardial tissue for ADAMTS1 in the 2 groups. However, in the study group, we observed no expression for ADAMTS1 around fibrotic areas but detected slight staining in coagulative and necrotic zones. Conclusion: Similar localizations of ADAMTS and fragmented versican in human heart tissue indicate that versican presumably is cleaved by ADAMTS1. Hence, ADAMTS1 can be regarded as a new marker for postmortem differential diagnosis of MI.
dc.identifier.citationPehlivan, S. vd. (2016). "The role of ADAMTS1 and versican in human myocardial infarction: A postmortem study". Laboratory Medicine, 47(3), 205-212.
dc.identifier.doi10.1093/labmed/lmw022
dc.identifier.endpage212
dc.identifier.issn0007-5027
dc.identifier.issn1943-7730
dc.identifier.issue3
dc.identifier.pubmed27346868
dc.identifier.scopus2-s2.0-85014440250
dc.identifier.startpage205
dc.identifier.urihttps://doi.org/10.1093/labmed/lmw022
dc.identifier.urihttps://academic.oup.com/labmed/article/47/3/205/2453835
dc.identifier.urihttp://hdl.handle.net/11452/32234
dc.identifier.volume47
dc.identifier.wos000381879800007
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherOxford University
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalLaboratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMedical laboratory technology
dc.subjectADAMTS1
dc.subjectMyocardial infarction
dc.subjectVersican
dc.subjectFragmented versican
dc.subjectPostmortem
dc.subjectDiagnosis
dc.subjectSudden cardiac death
dc.subjectHeart-failure
dc.subjectEndothelial-cells
dc.subjectStable angina
dc.subjectGene
dc.subjectExpression
dc.subjectFamily
dc.subjectAssociation
dc.subjectMotifs
dc.subject.emtreeADAMTS1 protein
dc.subject.emtreeVersican
dc.subject.emtreeADAMTS1 protein
dc.subject.emtreeADAMTS1 protein, human
dc.subject.emtreeVCAN protein, human
dc.subject.emtreeVersican
dc.subject.emtreeAdipose tissue
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeArticle
dc.subject.emtreeAutopsy
dc.subject.emtreeCarboxy terminal sequence
dc.subject.emtreeCell degeneration
dc.subject.emtreeControlled study
dc.subject.emtreeCytolysis
dc.subject.emtreeFemale
dc.subject.emtreeHeart
dc.subject.emtreeHeart infarction
dc.subject.emtreeHeart interstitium
dc.subject.emtreeHeart muscle necrosis
dc.subject.emtreeHuman
dc.subject.emtreeHuman tissue
dc.subject.emtreeImmunohistochemistry
dc.subject.emtreeMale
dc.subject.emtreeMiddle aged
dc.subject.emtreeMuscle cell
dc.subject.emtreeMuscle fibril
dc.subject.emtreeMyocytolysis
dc.subject.emtreeNerve fiber
dc.subject.emtreeNeutrophil chemotaxis
dc.subject.emtreeProtein expression
dc.subject.emtreeVacuolar degeneration
dc.subject.emtreeVascular endothelium
dc.subject.emtreeVery elderly
dc.subject.emtreeAdolescent
dc.subject.emtreeCardiac muscle
dc.subject.emtreeEvaluation study
dc.subject.emtreeHeart infarction
dc.subject.emtreePathology
dc.subject.emtreeProcedures
dc.subject.emtreeYoung adult
dc.subject.meshADAMTS1 protein
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshMyocardial infarction
dc.subject.meshMyocardium
dc.subject.meshPathology
dc.subject.meshVersicans
dc.subject.meshYoung adult
dc.subject.scopusProtein; Disintegrins; Aggrecanase
dc.subject.wosMedical laboratory technology
dc.titleThe role of ADAMTS1 and versican in human myocardial infarction: A postmortem study
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Adli Tıp Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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