PubMed

Permanent URI for this collectionhttps://hdl.handle.net/11452/24864

Browse

Now showing 1 - 20 of 757

Abatacept as a long-term targeted therapy for LRBA deficiency
(Elsevier, 2019-12) Kiykim, Ayça; Ogulur, İsmail; Dursun, Esra; Dogruel, Dilek; Karaca, Neslihan Edeer; Cogurlu, Mujde Tuba; Bilir, Ozlem Arman; Cansever, Murat; Kapakli, Hasan; Baser, Dilek; Kasap, Nurhan; Kutlug, Seyhan; Altintas, Derya Ufuk; Al-Shaibi, Ahmad; Agrebi, Nourhen; Kara, Manolya; Guven, Ayla; Somer, Ayper; Aydogmus, Cigdem; Ayaz, Nuray Aktay; Metin, Ayse; Aydogan, Metin; Uncuoglu, Aysen; Patiroglu, Turkan; Yildiran, Alisan; Guner, Sukru Nail; Keles, Sevgi; Reisli, Ismail; Aksu, Guzide; Kutukculer, Necil; Yilmaz, Mustafa; Karakoc-Aydiner, Elif; Lo, Bernice; Ozan, Ahmet; Chatila, Talal A.; Barıs, Safa; Çekiç, Şükrü; Kılıç, Sara Şebnem; Uludağ Üniversitesi/Tıp Fakültesi/Dahili Bilimler/Çocuk Sağlığı ve Hastalıkları; Uludağ Üniversitesi/Tıp Fakültesi/Dahili Bilimler/Çocuk Sağlığı ve Hastalıkları; 0000-0002-9574-1842; 0000-0001-8571-2581; L-1933-2017; 57094682600; 7102365439
BACKGROUND: LPS-responsive beige-like anchor (LRBA) deficiency presents with susceptibility to infections, autoimmunity, and lymphoproliferation. The long-term efficacy of cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (abatacept) as targeted therapy for its immune dysregulatory features remains to be established. OBJECTIVE: To determine the clinical and immunologic features of LRBA deficiency and long-term efficacy of abatacept treatment in controlling the different disease manifestations. METHODS: Twenty-two LRBA-deficient patients were recruited from different immunology centers and followed prospectively. Eighteen patients on abatacept were evaluated every 3 months for long-term clinical and immunologic responses. LRBA expression, lymphocyte subpopulations, and circulating T follicular helper cells were determined by flow cytometry. RESULTS: The mean age of the patients was 13.4 +/- 7.9 years, and the follow-up period was 3.4 +/- 2.3 years. Recurrent infections (n = 19 [86.4%]), immune dysregulation (n = 18 [81.8%]), and lymphoproliferation (n = 16 [72.7%]) were common clinical features. The long-term benefits of abatacept in 16 patients were demonstrated by complete control of lymphoproliferation and chronic diarrhea followed by immune dysregulation, most notably autoimmune cytopenias. Weekly or every other week administration of abatacept gave better disease control compared with every 4 weeks. There were no serious side effects related to the abatacept therapy. Circulating T follicular helper cell frequencies were found to be a reliable biomarker of disease activity, which decreased on abatacept therapy in most subjects. However, high circulating T follicular helper cell frequencies persisted in 2 patients who had a more severe disease phenotype that was relatively resistant to abatacept therapy. CONCLUSIONS: Long-term abatacept therapy is effective in most patients with LRBA deficiency.
ABO and RhD blood groups and their relationship with diseases: A retrospective study
(Professional Medical Publications, 2024-03) Göktaş, Olgun; Göktaş, Olgun; Uludağ Üniversitesi/Aile Sağlığı Merkezi; EXQ-8413-2022
Objective: To retrospectively evaluate the distribution of ABO and RhD blood groups and their relationship with diseases. Methods: The retrospective study was carried out in Bursa Uludag University Family Health Center in Turkey between 1-28 February, 2023. The data of individuals who were registered with the Family Health Center and whose blood types were known were evaluated retrospectively. Blood group type, sociodemographic findings, existing diseases, allergies, and genetic disease conditions were obtained. P-values below 0.05 were considered statistically significant. Analysis were made in the SPSS 25.0 program. Results: A total of 3834 people, 1935 male (50.5%) and 1899 female (49.5%) participated in the study. The mean age of the individuals was 26.45 +/- 10.45 years. About 75.8 percent of the participants were university students, 6.3 percent were health workers, and 17.9 percent were from other occupational groups. The rates of blood groups were determined as O Rh D+ at 33.5%, AB Rh D+ at 26.9%, A Rh D+ at 14.9%, AB Rh D- at 7.7%, B Rh D+ at 7%, O Rh D- at 4.6%, B Rh D- at 3.2% and A Rh D- at 2.2%. It was determined that the O Rh D- group had a higher rate of genetic disease than the other groups (p=0.01). Conclusion: It was determined that the O Rh D+ blood group was found more frequently in our region's population than in other groups. This different result depending on the A Rh D+ blood group, which is the most common throughout the country may have reflected the influence of different geographical regions and ethnic characteristics due to the students in our population. In addition, the results regarding the relationships between blood groups and occupation, genetics, existing disease, presence of allergies, and visual defects in the eye are important.
Acaricidal activity of Origanum bilgeri PH Davis (Lamiaceae) essential oil and its major component, carvacrol against adults Rhipicephalus turanicus (Acari: Ixodidae)
(Elsevier, 2013-03) Koç, Samed; Öz, Emre; Cinbilgel, İlker; Çetin, Hüseyin; Aydın, Levent; Uludağ Üniversitesi/Veterinerlik Fakültesi/Parazitoloji Anabilim Dalı.; 55808198600
The acaricidal activity of an essential oil obtained from aerial parts of Origanum bilged P.H. Davis (Lamiaceae), an endemic species in Turkey, and its major constituents, carvacrol was evaluated against unfed adults Rhipicephalus turanicus Pomerantzev (Acari: Ixodidae) collected from Kepez, Antalya. The composition of the essential oil was analyzed by GC/MS. The major compound identified in the oil was carvacrol (93.02%). Generally, tick mortalities to the O. bilged distillate and carvacrol increased with concentrations. O. bilged oil produced >83% mortality at 48 h at a concentration of 0.8% and mortality was higher than 63% at a carvacrol concentration of 0.4%. Our results have shown that O. bilged essential oil and its major component, carvacrol, may have potential as acaricidal agents against R. turanicus.
Acaricidal activity of the essential oils from three lamiaceae plant species on rhipicephalus turanicus pom. (acari: ixodidae)
(Springer, 2012-10) Koç, Samed; Öz, Emre; Çetin, Hüseyin; Aydın, Levent; Uludağ Üniversitesi/Veteriner Fakültesi/Parazitoloji Anabilim Dalı.; 0000-0002-2875-8003; 55808198600
Acaricidal effects of three Labiatae essential oils extracted from ariel parts of Thymus sipyleus Boiss. subsp. sipyleus, Mentha longifolia L., and Dorystoechas hastata Boiss. & Heldr. ex Bentham on 10-day-old Rhipicephalus turanicus Pom. (Acari: Ixodidae) larvae were evaluated by using the larval packet test bioassay. Serial dilutions of the three essential oils were tested from a starting concentration of 1-0.1 % (1.0, 0.5, 0.25, and 0.1 % w/v). Results showed that all essential oils had very similar activity, producing complete mortality (100 %) in all tested concentrations on 10-day-old R. turanicus tick larvae.
Accuracy of anatomical references used for rotational alignment of tibial component in total knee arthroplasty
(Springer, 2012-03) Şahin, Namık; Öztürk, Alpaslan; Özkan, Yüksel; Avcu, Bülent; Atıcı, Teoman; Özkaya, Güven; Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi ve Travmatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-0297-846X; A-4421-2016; A-5095-2018; 7801647288; 16316866500
This study aimed to research which was the most reliable of the four techniques based on local anatomic markers used to determine tibial component rotation in total knee arthroplasty, and whether the markers varied in knees with varus deformity. The study included 33 knees with a normal anatomic axis and 32 knees with a varus deformity and osteoarthritis. On the MR images, the femoral transepicondylar axis (TEA) was determined and transposed to the standard tibial resection level. At this level, four axes were drawn on the axial sections: tibial posterior condylar line (PC), tibial plateau anterior line (AC), a vertical line (AA) drawn to Akagi's line, and the maximal mediolateral distance (MMLD). The relationships of these lines and the transposed TEA were compared between two groups. In all the knees, the mean values of the PC, AA, and MMLD axes compared to TEA reference were 5.5A degrees A A +/- A 5.7 (mean +/- A SD), 7A degrees A A +/- A 3.2, and 6.7A degrees A A +/- A 8.1 internal rotation, respectively, and the AC axis was 8.9A degrees A A +/- A 6.7 external rotation. In the AC, AA, and MMLD axes, the change occured because of varus deformity was statistically meaningful. For all the observers, the axis with the least SD and the most accuracy was the AA axis. Of the four axes used to determine tibial component rotation, only the PC axis is not affected by varus deformity, and the least affected axis according to the observers was the AA axis, and thus the AA and PC axes can be used for guidance in determining the rotation of the tibial component. Prognostic studies-investigating natural history and evaluating the effect of a patient characteristic: High-quality prospective cohort study with > 80% follow-up, and all patients enrolled at same time point in disease, Level I.
Acitretin-induced subungual hemorrhage
(Wiley, 2007-04-30) Aydoğan, Kenan; Karadoğan, Serap Köran; Tunalı, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; 0000-0002-0193-1128; 9739755800; 9738885800; 7004191748
A 20-year-old woman with a 2-year history of histologically confirmed palmoplantar keratoderma due to psoriasis, resistant to several topical agents, was admitted to the Department of Dermatology, Uludag University, Bursa, Turkey. Therapy with oral acitretin (0.5mg/kg/day, 35mg/day) was initiated. A month after starting acitretin treatment, she noted slight reddening of the second left fingernail. Clinical examination revealed red-brown discoloration of the second fingernail associated with subungual hemorrhage involving the proximal nail bed (lunula region) (Fig. 1). The nail change was asymptomatic. The patient complained only of discoloration underneath the nail plate. No abnormalities were detected on the skin, mucous membranes, or toenails/ other fingernails. The patient denied exposure to microtrauma or any other drugs. The erythrocyte sedimentation rate, full blood cell count, electrolytes, renal and hepatic tests, and serum lipids were normal. Coagulation tests, including blood clotting time, international normalized ratio, activated partial thromboplastin time, thrombin time, platelet number, and function tests, were within normal levels. Treatment with acitretin was discontinued, and the nail change resolved completely after 3 weeks. A similar episode of subungual hemorrhage recurred, however, within 48 h after re-challenge with a lower dose of acitretin (25 mg/day). The drug was definitively stopped and the eruption faded again within a week. An objective causality assessment suggests that subungual hemorrhage was probably related to acitretin in this patient.
Acroangiodermatitis in a below-knee amputation stump
(Wiley, 2011-07) Turan, Hakan; Başkan, Emel Bülbül; Adım, Şaduman Balaban; Sarıcaoğlu, Hayriye; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-0144-3263; AAH-1388-2021; 6602518817; 15730076300; 6603722836
Active and total ghrelin concentrations increase in breast milk during lactation
(Wiley, 2007-11) İlçöl, Yeşim Özarda; Hızlı, Banu; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; AAL-8873-2021; 35741320500; 14019332100
Aim: To assess ghrelin status in breast milk and maternal serum for up to 180 days during lactation and to determine relationships between the concentrations of ghrelin in mother's milk and in serum of breastfed infants. Methods: Blood and breast milk samples were collected from 159 breastfeeding women enrolled either in the first 3 days, or in days 4-14, 15-30, 31-90 and 91-180 postpartum. Blood samples were also collected from 49 breastfed infants at 4-30 days of age. Milk and serum active and total ghrelin concentrations were measured by radioimmunoassay. Results: Active and total ghrelin concentrations in breast milk were lowest (450 ± 25 and 880 ± 80 pg/mL, respectively) at 0-3 days, whereas they increased progressively during 180 days of lactation period to 801 ± 43 and 3250 ± 380 pg/mL at 91-180 days postpartum. Milk total ghrelin concentrations correlated with serum concentrations of active (r = 0.503; p < 0.001) and total ghrelin (r = 0.331; p < 0.05) in breastfed infants at 4-30 days of age. In breastfeeding women, serum total ghrelin concentrations increased whereas serum active ghrelin concentrations decreased significantly during the next 4-180 days. Conclusion: Active and total ghrelin concentrations in breast milk increase with time during lactation and show significant relations with serum ghrelin concentrations in breastfed infants.
Acute lasalocid poisoning in calves associated with off-label use
(Wiley, 2011-04) Oruç, Hasan Hüseyin; Cangül, İbrahim Taci; Cengiz, Murat; Yılmaz, Rahşan; Uludağ Üniversitesi/Veterinerlik Fakültesi/Farmakoloji ve Toksikoloji Anabilim Dalı.; Uludağ Üniversitesi/Veterinerlik Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-5399-2395; 0000-0002-0944-2230; 0000-0003-0537-2113; ABE-5935-2020; AAI-2212-2021; ABG-8940-2020; AAB-4360-2021; 55944769400; 6602486125; 16635026700; 15057258600
Adrenomedullin-a new marker in febrile neutropenia: Comparison with CRP and procalcitonin
(Taylor & Francis, 2015-10-03) Tuğcu, Deniz; Akçay, Arzu; Aydoğan, Gönul; Akıcı, Ferhan; Salcıoğlu, Zafer; Ekmekçi, Hakan; Sevinir, Betül; Ekmekçi, Özlem Balcı; Demirkaya, Metin; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; EUG-4353-2022; 24331130000
In this study, we aimed to determine serum adrenomedullin levels and compare them with levels of C-reactive protein (CRP) and procalcitonin (PCT). Cancer patients aged 0-18years who experienced febrile neutropenia attacks were included in the study. Adrenomedullin, CRP, and PCT were analyzed at admission, day 3, and days 7-10 later. Fifty episodes of febrile neutropenia that developed in 37 patients were analyzed in this study. The mean age of the patients was 7.5 +/- 4.7 (1-18) years. The patients had leukemia (73%), solid tumors (19%), and lymphoma (8%). The percentages of the patients in the clinically documented infection (CDI), fever of unknown origin (FUO), sepsis, and microbiological documented infection (MDI) categories were 34%, 34%, 20%, and 12%, respectively. During the study period, four patients were lost. In the MDI group, adrenomedullin levels on day 3 were significantly higher than those in the CDI and FUO groups. PCT levels were significantly higher in the sepsis group than those in the CDI group at admission, day 3, and days 7-10. In the sepsis group, PCT levels on days 7-10days were significantly higher than those in the sepsis group. PCT values from the deceased patients on days 7-10 were significantly higher than those from patients who survived. CRP levels did not differ significantly among the febrile neutropenia groups. First, in our study, adrenomedullin was used as a biomarker in the febrile neutropenia episodes of children with cancer. Among adrenomedullin, CRP, and PCT, procalcitonin demonstrates the highest correlation with the severity of infection.
Advances and highlights in biomarkers of allergic diseases
(Willey, 2021-12) Ardıçlı, Özge; Bursa Uludağ Üniversitesi/Karacabey Meslek Yüksekokulu/Gıda İşleme Bölümü; AAG-7421-2021; 57219362332
During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical burden. A large fraction of allergic diseases is characterized by a type 2 immune response involving Th2 cells, type 2 innate lymphoid cells, eosinophils, mast cells, and M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on the disease endotypes, clusters, precision diagnoses, identification of therapeutic targets, and monitoring of treatment efficacies. The availability of powerful omics technologies, together with integrated data analysis and network-based approaches can help the identification of clinically useful biomarkers. These biomarkers need to be accurately quantified using robust and reproducible methods, such as reliable and point-of-care systems. Ideally, samples should be collected using quick, cost-efficient and noninvasive methods. In recent years, a plethora of research has been directed toward finding novel biomarkers of allergic diseases. Promising biomarkers of type 2 allergic diseases include sputum eosinophils, serum periostin and exhaled nitric oxide. Several other biomarkers, such as pro-inflammatory mediators, miRNAs, eicosanoid molecules, epithelial barrier integrity, and microbiota changes are useful for diagnosis and monitoring of allergic diseases and can be quantified in serum, body fluids and exhaled air. Herein, we review recent studies on biomarkers for the diagnosis and treatment of asthma, chronic urticaria, atopic dermatitis, allergic rhinitis, chronic rhinosinusitis, food allergies, anaphylaxis, drug hypersensitivity and allergen immunotherapy. In addition, we discuss COVID-19 and allergic diseases within the perspective of biomarkers and recommendations on the management of allergic and asthmatic patients during the COVID-19 pandemic.
Advances and recent developments in asthma in 2020
(Wiley, 2020-09-30) Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; 0000-0003-2287-3569; 57216918051
In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis, and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis, and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping, and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers, are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2, and COVID-19.
Aetiological role of viruses in puppies with diarrhoea
(Wiley, 2007-08-04) Özkul, Aykut; Pratelli, Alberto; Yılmaz, Zeki; Yeşilbağ, Kadir; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Bölümü.; 0000-0001-9836-0749; 00424900; 6602912127; 35944810500
Air-soil exchange of PCBs: Seasonal variations in levels and fluxes with influence of equilibrium conditions
(Elsevier Science, 2012-10) Taşdemir, Yücel; Salihoğlu, Güray; Salihoğlu, Nezih Kamil; Birgül, Aşkın; Uludağ Üniversitesi/Mühendislik-Mimarlık Fakültesi/Çevre Mühendisliği Bölümü.; 0000-0002-7718-0340; AAG-9413-2021; AAG-9468-2021; AAG-9399-2021; F-7879-2015; 6603118338; 8551769300; 55665111200; 12795386100
The variations in the occurrences of PCB congeners both in soil and air were investigated in conjunction with each other, and the changes in the fugacity fractions and flux levels were examined on a seasonal basis. Air and soil samples were collected concurrently two or three times in a month during a one-year monitoring at two different locations in Bursa, located in the northwestern Turkey. Fugacity fractions and net flux levels of PCB congeners were calculated. Air and soil PCB levels increased together as the soil temperature increased, suggesting the influence of instantaneous air-soil exchange towards the equilibrium conditions. The flux levels and fugacity fractions also showed a positive significant correlation with soil temperature. Flux levels were positive for the dates with fugacity fractions above 0.5, indicating volatilization from soil to air.
Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain
(Blackwell Publishing, 2018-01) Ergün, D.; Jackson, A.; Toma, W.; Schulte, M. K.; Damaj, M. I.; Bağdaş, Deniz; Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi.; 15062425700
BackgroundNeuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels. The 42 subtype of nAChRs plays an important role in the mediation of pain and several nicotine-evoked responses. Agonists and partial agonists of 42 nAChRs show efficacy in animal pain models. In addition, the antinociceptive properties of nicotine, a non-selective nAChR agonist with a high affinity for 42 nAChRs, is well-known. There is a growing body of evidence pointing to allosteric modulation of nAChRs as an alternative treatment strategy in experimental pain. Desformylflustrabromine (dFBr) is a positive allosteric modulator (PAM) at 42 nAChRs that enhances agonist responses without activating receptors. We hypothesized that dFBr may enhance nicotine-induced antinociception. MethodsThe present study investigated whether dFBr could attenuate mouse chronic constriction injury (CCI)-induced neuropathic pain by increasing endogenous cholinergic tone or potentiating the nicotine-evoked antiallodynic response. ResultsWe found that subcutaneous administration of dFBr failed to reduce pain behaviour on its own. However, the combination of dFBr with nicotine significantly reversed neuropathic pain behaviour dose- and time-dependently without motor impairment. Our data revealed that this effect was mediated by the 42 nAChRs by using competitive 42 antagonist dihydro--erythroidine. In addition, dFBr failed to potentiate the antiallodynic effect of morphine, which shows the effect of dFBr is unique to 42 nAChRs. ConclusionsThe present results suggest that allosteric modulation of 42 nAChR may provide new strategies in chronic neuropathic pain. Significance42 nAChRs are involved in pain modulation. dFBr, a PAM at 42 nAChRs, potentiates the nicotine response dose-dependently in neuropathic pain. Thus, the present results suggest that allosteric modulation of 42* nAChR may provide new strategies in chronic neuropathic pain.
Alpha v beta 3 integrin antagonists enhance chemotherapy response in an orthotopic pancreatic cancer model
(Frontiers Media, 2020-01-27) Sudha, Thangirala; Bharali, Dhruba J.; Davis, Paul J.; Mousa, Shaker A.; Coşkun, Melis Debreli; Çelikler, Serap; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; 0000-0002-4177-3478; CML-2517-2022; 57194630463; 8234554800
Pancreatic cancer decreases survival time and quality of life because of drug resistance and peripheral neuropathy during conventional treatment. This study was undertaken to investigate whether alpha v beta 3 integrin receptor antagonist compounds NDAT and XT199 can suppress the development of cisplatin resistance and cisplatin-induced peripheral neuropathy in an orthotopic pancreatic SUIT2-luc cancer cell mouse model. Anticancer effects of these compounds and their combination with cisplatin were assessed in this tumor mouse model with bioluminescent signaling and histopathology, and a cytokine assay was used to examine expression of inflammatory cytokines IL-1 beta, IL-6, IL-10, and TNF-alpha from plasma samples. To determine the neuroprotective effects of the compounds on cisplatin-induced peripheral neuropathy, behavioral hind-limb posture of the mice was evaluated. The combination therapy of NDAT or XT199 with cisplatin elicited greater inhibition of tumor growth and increased tumor necrosis compared to cisplatin alone. NDAT and XT199 in combination with cisplatin significantly decreased expression of pro-inflammatory cytokines IL-1 beta, IL-6, and TNF-alpha and significantly increased expression of anti-inflammatory cytokine IL-10 in comparison to cisplatin alone. Cisplatin-treated groups showed stocking-glove hind-limb posture, whereas NDAT and XT199 with cisplatin-treated groups displayed normal hind-limb posture. Results clearly suggest that NDAT and XT199 treatment with cisplatin that inactivates NF-kappa B may contribute to increased antitumor and anti-inflammatory efficacy as well as alleviate cisplatin-mediated loss of motor function in this pancreatic tumor mouse model.
Ambient air levels and trends of polychlorinated biphenyls at four different sites
(Springer, 2010-11) Taşdemir, Yücel; Cindoruk, Sabahattin Sıddık; Uludağ Üniversitesi/Mühendislik Fakültesi/Çevre Mühendisliği Bölümü.; 0000-0001-7536-0332; AAG-9468-2021; 10339194600; 6603118338
In this study, samples were collected in order to determine atmospheric levels of polychlorinated biphenyls (PCBs) in four different sites by using a high-volume air sampler (HVAS). Eighty-three congeners of gas and particle- phase PCBs were investigated in air samples. The total (gas + particle) concentrations for Mudanya (coastal), Butal (traffic/urban), the Uludag University Campus (semirural), and Yavuz Selim (residential) were determined as 570, 394, 412, and 316 pg/m(3), respectively. These levels coincide with the values reported for the sites having similar characteristics. In terms of homolog groups, 3-chlorinated biphenyls (3-CBs) and 4-CBs constituted at least 47% of the total PCB concentration. PCBs in all sites were determined mostly in the gas phase, with a percentage from 85 to 95%. Obtained atmospheric PCB data were correlated with meteorological parameters and a significant relationship was obtained between coastal and semirural sites (p < 0.05). With the movements of air transportation and wind rose possible data sources of PCBs were enlightened. Partitioning of gas/particle was examined with available models; significant relationships were determined for coastal and semirural sites especially.
Amplitude analysis of d-s(+) -> pi(+)pi(0)eta and first observation of the w-annihilation dominant decays d-s(+) -> a(0)(980)(+)pi(0) and d-s(+) -> a(0)(980)(0)pi(+)
(American Physical Society, 2019-09-12) Yan, Wenbiao; Bursa Uludağ Üniversitesi.; 35770088900
We present the first amplitude analysis of the decay D-s(+) -> pi(+)pi(0)eta. We use an e(+)e(-) collision data sample corresponding to an integrated luminosity of 3.19 fb(-1) collected with the BESIII detector at a center-of-mass energy of 4.178 GeV. We observe for the first time the W-annihilation dominant decays D-s(+) -> a(0)(980)(+)pi(0) and D-s(+) -> a(0)(980)(0)pi(+). We measure the absolute branching fraction B(D-s(+) -> a(0)(980)(+(0))pi(0(+)), a(0)(980)(+(0)) -> pi(+(0))eta = (1.46 +/- 0.15(stat) +/- 0.23 sys)%, which is larger than the branching fractions of other measured pure W-annihilation decays by at least one order of magnitude. In addition, we measure the branching fraction of D-s(+) -> pi(+)pi(0)eta with significantly improved precision.
Analysis of diffracted fields with the extended theory of the boundary diffraction wave for impedance surfaces
(Optical Soc Amer, 2011-06) Yalçın, Uǧur; Uludağ Üniversitesi/Mühendislik Fakültesi/Elektrik ve Elektronik Mühendisliği Bölümü.; AAG-8951-2021; 16023664100
Uniform diffracted fields from impedance surfaces are investigated by the extended theory of boundary diffraction wave (ETBDW). The new vector potential of the ETBDW is constructed by considering the pseudoimpedance boundary condition. The method is applied to the diffraction problem from an impedance half-plane. It is shown that the total fields from an impedance half-plane reduce to the case of a perfectly electric or magnetic conducting and opaque half-plane for special values of surface impedance. The total and diffracted fields are compared numerically with the exact solution for the impedance half-plane and modified theory of physical optics (MTPO) solution for an impedance wedge. The numerical results show that the field expressions are in very good agreement with the exact and MTPO solutions.
Analysis of intracranial pressure changes during early versus late percutaneous tracheostomy in a neuro-intensive care unit
(Springer, 2008-12) Kocaeli, Hasan; Korfali, Ender; Taşkapilioğlu, Özgür; Özcan, Tekin; Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.; V-1196-2018; 6603500567; 7004641343; 6506852772; 25636374000
Background We aimed to investigate intracranial pressure (ICP) changes during early versus late bedside percutaneous tracheostomy (PT) in a neuro-intensive care unit (NICU). Methods This study included 30 patients admitted to our NICU for head trauma, subarachnoid haemorrhage, intracerebral haematoma or brain tumour with a Glasgow Coma Score (GCS) less than 8. These patients also underwent ICP monitoring. Bedside PT was performed either early (within 7 days of ventilation) or late (after 7 days of ventilation) via the Griggs system. In all patients; ICP, systemic blood pressure, heart rate, oxygen saturation (Sat O(2)) and arterial blood gases were recorded 5 min before the procedure, during skin incision, during tracheal cannulation, as well as 5 min and 10 min after the procedure. Findings Thirty patients, 18 male and 12 female, with various intracranial pathologies between ages 18 and 78 (mean 38.7 +/- 20) were identified. The admission GCS ranged between 4 and 11 (median 7). Physiological variables did not differ significantly between the two groups. In the early group, ICP values measured 5 min before the procedure, during skin incision, during tracheal cannulation, as well as 5 min and 10 min after the procedure were 15.1 +/- 5.2, 22 +/- 10.1, 28.4 +/- 13.7, 17.3 +/- 7.1, 13.8 +/- 5.0 mmHg, respectively. In the late group, these values were 14.2 +/- 4.5, 17.2 +/- 5.5, 21.5 +/- 8.0, 15.1 +/- 5.3 and 12.4 +/- 4.1 mmHg. There was no significant difference between the early or late groups in terms of ICP increases during these predetermined 5 time points. Conclusions In patients with decreased intracranial compliance, a relatively minimally invasive procedure such as PT may lead to significant increases in ICP. The timing of PT does not seem to influence ICP, mortality, pneumonia or early complications. During the PT procedure, ICP should be closely monitored and preventive strategies should be instituted in an attempt to prevent secondary insult to an already severely injured brain.

Browse

Browsing by Language "en"