Browsing by Author "van de Veen, Willem"

Filter results by typing the first few letters
Now showing 1 - 3 of 3
  • Thumbnail Image
    Publication
    IL-10 induces IgG4 production in NOD-scid Il2rγnull mice humanized by engraftment of peripheral blood mononuclear cells
    (Wiley, 2021-08-07) Cevhertaş, Laçin; Ma, Siyuan; Stanic, Barbara; Ochsner, Urs; Jansen, Kirstin; Ferstl, Ruth; Frei, Remo; Chijoke, Obinna; Munz, Christian; Zhang, Luo; O'Mahony, Liam; Akdis, Mubeccel; van de Veen, Willem; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Tıbbi İmmünoloji Anabilim Dalı.; 0000-0003-2287-3569; EOW-6245-2022
  • Thumbnail Image
    Publication
    Innate lymphoid cell subsets in obese asthma patients: Difference in activated cells in peripheral blood and their relationship to disease severity
    (Wiley, 2022-05-30) Çelebi Sözener, Zeynep; Cevhertaş, Laçin; Satitsuksanoa, Pattraporn; van de Veen, Willem; Jansen, Kirstin; Seçil, Derya; Sin, Betül Ayşe; Akdiş, Cezmi A.; Akdiş, Mübeccel; Mungan, Dilşad; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Fen Bilimleri Enstitüsü/Tıbbi İmmünoloji Anabilim Dalı.; FYD-1431-2022
  • Thumbnail Image
    Publication
    Regulatory B cells, A to Z
    (Wiley, 2021-02-02) Jansen, Kirstin; Cevhertaş, Laçin; Ma, Siyuan; Satitsuksanoa, Pattraporn; Akdis, Mubeccel; van de Veen, Willem; Cevhertaş, Laçin; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Tıbbi İmmünoloji Bölümü.; FYD-1431-2022
    B cells play a central role in the immune system through the production of antibodies. During the past two decades, it has become increasingly clear that B cells also have the capacity to regulate immune responses through mechanisms that extend beyond antibody production. Several types of human and murine regulatory B cells have been reported that suppress inflammatory responses in autoimmune disease, allergy, infection, transplantation, and cancer. Key suppressive molecules associated with regulatory B-cell function include the cytokines IL-10, IL-35, and TGF-beta as well as cell membrane-bound molecules such as programmed death-ligand 1, CD39, CD73, and aryl hydrocarbon receptor. Regulatory B cells can be induced by a range of different stimuli, including microbial products such as TLR4 or TLR9 ligands, inflammatory cytokines such as IL-6, IL-1 beta, and IFN-alpha, as well as CD40 ligation. This review provides an overview of our current knowledge on regulatory B cells. We discuss different types of regulatory B cells, the mechanisms through which they exert their regulatory functions, factors that lead to induction of regulatory B cells and their role in the alteration of inflammatory responses in different diseases.