Browsing by Author "Uyar, Yavuz"

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    Crimean-Congo Hemorrhagic Fever infection in domestic animals in Marmara region, Western Turkey
    (Ankara Üniversitesi, 2014) Dinçer, Ender; Uyar, Yavuz; Özkul, Aykut Ayaz; Tuncer, Pelin Göktuna; Yeşilbağ, Kadir; Alpay, Gizem; Girişgin, Ahmet Onur; Aydın, Levent; Uludağ Üniversitesi/Veterinerlik Fakültesi/Klinik Öncesi Bilimler Bölümü.; 0000-0002-0020-2708; 0000-0002-7468-0155; 0000-0002-3411-081X; ABE-7662-2020; B-5286-2017; AAC-6294-2020; AAH-3917-2021; 54787022200; 6602912127; 54079452300; 16030783600; 55808198600
    Crimean-Congo hemorrhagic fever (CCHF) has been an important health issue in Turkey since the last decade. Although there is a well-described endemic area, the infection tends to disseminate into non-endemic areas. In the South Marmara region, a non-endemic area, serological and virological investigations were performed to evaluate the infection status in livestock animals. Among 508 blood samples collected from 5 different locations, 33.1% were positive for CCHF-neutralizing antibodies. The highest seroprevalence rate was detected in goats (66.0%), followed by sheep (31.8%) and cattle (13.0%) (p<0.0001). There were extensive differences in seroprevalence rates in neighboring locations, i.e., 7.8% in Keles and 47.6% in the Orhaneli district of Bursa province. Using antigen-capture ELISA (Ag-ELISA) and real-time reverse transcription PCR (rt RT-PCR), 6.6% of the tested animals were found to be viremic at the time of sampling. Two samples that were negative by Ag-ELISA produced a positive signal in rt RT-PCR, indicating the higher sensitivity of the latter method for detecting viremic animals. The results of this study demonstrate the wide distribution of CCHF virus in some locations in a non-endemic area, which may lead to the generation of focal infectious areas.