Browsing by Author "Ozan, Hakan"

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Acute effects of maternal smoking on the uterine and umbilical artery blood velocity waveforms
(Springer Verlag, 1998) Kimya, Yalçın; Cengiz, Candan; Ozan, Hakan; Kolsal, Nedret; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Objective: The acute effects of smoking during pregnancy on the uterine and umbilical blood flow velocity waveform were assessed. Methods: Twenty-two chronic women smokers at a mean gestational age of 194.17 +/- 58.02 days and 21 women nonsmokers at a mean gestational age of 193.24 +/- 34.71 days were studied. Systolic-diastolic (S/D) ratio, resistance index, and pulsatility index of uterine and umbilical arteries were measured in the control group and before and after smoking a single standard 100-mm filtered cigarette in the study group. Results: There was no significant change in the uterine artery and umbilical artery blood velocity waveform indices that could be attributed to the acute effect of smoking in the study group, but all of the uterine artery indices and S/D ratio in the umbilical artery were statistically higher in the study group in comparison with the control group both before and after smoking. Conclusion: Our results suggest that smoking causes an increase in vascular resistance of the placenta and umbilical cord when used chronically.
Adjunctive use of the uterine artery resistance index in the preoperative prediction of myometrial invasion in endometrial carcinoma
(Academic Press Inc Elsevier Science, 1999) Yalçın, Ömer T.; Özalp, Sinan; Develioğlu, Osman H.; Bilgin, Tufan; Ozan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Objective. The aim of this study was to evaluate the value of transvaginal ultrasonography (TVUS) and uterine artery flow velocimetry indices in the preoperative detection of deep myometrial invasion in endometrial carcinoma (EC). Methods. Thirty-nine patients with EC underwent TVUS and Doppler flow velocimetry studies, during which endometrial, myometrial, and uterine measurements, presence and depth of myometrial invasion, and pulsatility and resistance indices (PI and RI, respectively) of uterine arteries were noted. TVUS and Doppler findings were correlated with pathological findings obtained by surgical staging. The respective diagnostic accuracies of these variables, and of age and grade, in detecting deep myometrial invasion were assessed with the use of histological findings as the standard. Results. All patients with Grade 3 tumors had deep myometrial invasion, compared to 19% of patients with Grade 1 tumors. The mean age of patients with deep invasion was significantly higher, and their mean PI and RI were significantly lower, than patients with lesser degrees of invasion. While the sensitivity and specificity of TVUS in detecting deep invasion were 37 and 90%, respectively, the corresponding figures for age, grade, and uterine artery RI, found to be independent discriminators of deep invasion, were in the range of 58-84% and 60-70%. The combined use of the latter three parameters resulted in a sensitivity of 100% and specificity of 95%. Conclusions. Our findings indicate that TVUS is unreliable in diagnosing deep myometrial invasion. Detection rates of this pathological feature can be greatly improved, however, with the concomitant use of age, tumor grade, and uterine artery RI.
Alterations in respiratory functions during magnesium sulfate infusion in severe preeclampsia and eclampsia
(Elsevier Sci Ireland, 1994) Bilgin, Tufan; Cengiz, Çokluk; Ozan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Angiogenesis in endometrial carcinoma: Correlation with survival and clinicopathologic risk factors
(Karger, 2003) Özuysal, Sema; Bilgin, Tufan; Ozan, Hakan; Kara, H. Filiz; Öztürk, Hülya; Ercan, İlker; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-2382-290X; 56616314600; 7004103925; 7003908072; 36845105800; 57197115377; 6603789069
Association among angiogenesis, survival and clinicopathologic parameters in endometrial carcinoma was evaluated. Sixty patients who had been diagnosed as endometrial carcinoma, from 1993 to 1998, were included in the study. All patients had been surgically staged with bilateral pelvic and para-aortic lymph node dissection. All hysterectomy specimens were stained immunohistologically for factor VIII-related antigen. The area with the most intensified microvasculature was determined under low-power (x 100) magnification, and the microvessel count of this area under high-power (x 200) magnification was determined as the microvessel density (MVD) of the tumor. The mean MVD was 26.2 +/- 13.0 (range 6-68), and it was considered as high (n = 24; 40%), moderate (n = 19; 31.7%) and low (n = 17; 28.3%) when the MVD was >30, between 15-30 and <15, respectively. Statistical analysis included Mann-Whitney, Kruskal-Wallis and Spearman rank correlation tests. The Kaplan-Meier method was used to evaluate the difference between angiogenesis and survival. Multivariate analysis with the Cox regression model was used in MVD values and different clinicopathological parameters. There was positive correlation between MVD increase and surgicopathological stage (p < 0.05). A significant difference was seen between MVD increase and lymph node metastasis (p < 0.05). There were no differences between MVD and age, histological type, grade and lymphovascular invasion. MVD did not change in association with myometrial invasion depth. There was a significant difference in means of survival between the low and high MVD groups (p = 0.01). However, MVD was not an independent prognostic factor in multivariate analysis. Increased angiogenesis was found to be associated with advanced stage and decreased survival in endometrial carcinoma.
Anticardiolipin antibodies in pregnancy induced hypertension
(Elsevier, 1996) Uncu, Gürkan; Ozan, Hakan; Küçükerdoğan, İsmail; Cengiz, Candan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
It was suggested that anticardiolipin antibodies (ACA) were found positive in some obstetrical problems such as recurrent foetal losses, intrauterine growth retardation, etc. The aim of this study was to determine ACA levels in pregnancy induced hypertension (PIH) cases. ACA IgG and IgM levels were measured by the ELISA method in 65 PIH cases and 23 control pregnancies. We could not find any difference between the PIH and the control groups. There was not any statistically significant difference between the subtypes of PIH. According to these results, we say that ACA IgG and IgM levels have no diagnostic and prognostic value in PIH.
Borderline over tümörlü olgulara klinik yaklaşım
(Uludağ Üniversitesi, 2013-01-02) Korkmazer, Neşe Solak; Özmen, Turan; Ozan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Jinekolojik Onkoloji Bilim Dalı.
Çalışmada 2008-2012 yılları arasında, kliniğimizde cerrahi olarak tedavi edilen borderline over tümörü tanılı olguların verileri retrospektif taranarak; klinik özellikleriyle birlikte uygulanan tedavi prosedürlerinin ortaya konulması amaçlanmıştır. Çalışmaya 31 olgu dahil edildi. Olguların, medyan yaşı 40 (18-86) yıl idi ve %74,2’si premenopozaldi (n=23). Medyan tümör çapı 10,5 (3-40) cm’di. En sık postoperatif histolojik tanı; %70,9 (n=22) seröz tip tümörlerdi. Seröz tümorlerin medyan çapı 9 (3-30) cm ve müsinözlerde tümör çapı 20 (4-40) cm’di. Cerrahi öncesinde tümör belirteçleri % 46,4 (n=13) hastada yüksek saptandı. Yirmi yedi hastada frozen kesit uygulandı (%87), frozen uygu lanan olguların % 80,7’inde (21/26), frozen kesitlerinde borderline tümör tanısı konuldu. Operasyon şekli açısından olguların analizinde, hastaların % 54,8’inde (n=17) histerektomi ve bilateral salpingooferektomi uygulanmıştı ve bu olguların % 77,8’i (n=13) 40 yaş ve üzeriydi. Bu bulgular, genç ve fertilite isteği olan olgularda daha sık görülmesi ve Ca 125 değerlerinin genelde normal olması nedeniyle, şüphelenildi ğinde, bu tümörlerde operasyon esnasında frozen kesit alınması ve fertilite koruyucu cerrahi prosedürlerin göz önünde bulundurulması gerektiğini göstermektedir.
A case of hepatoid carcinoma of the ovary
(Imr Press, 2008) Ozan, Hakan; Nazlıoğlu, Hülya Öztürk; Özuysal, Sema; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/kadın Hastalıkları ve Doğum Anabilim Dalı.; 7003908072; 56616314600; 57197115377
A 50-year-old female was admitted with abdominal distention. Her serum CA125 level was elevated. Ultrasonography and computerized tomography showed adnexal tumoral masses with intraperitoneal metastases but no hepatic parenchymal involvement. She was operated oil and histopathological and immunohistochemistry findings indicated ovarian hepatoid tumor. We present this case of ovarian hepatoid tumor and discuss the two-year disease progression from diagnosis to death.
A case with three primary tumors of the ovary, endometrium and gallbladder
(IMR Press, 2008) Ozan, Hakan; Özerkan, Kemal; Aker, Sibel; Bülbül, Mehmet; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0001-5695-2586; A-6588-2019; AAH-9791-2021; 7003908072; 6603345841; 12795285000; 7004692452
A case with three synchronous tumors is presented. A 52-year-old patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy, bilateral pelvic kind paraaortic lymph node dissection. and partial omentectomy for endometrial carcinoma accompanied by an adnexal mass. She further underwent cholecystectomy for a perioperative incidental suspicious nodule on the serosal surface of the gallbladder. Histopathology revealed a uterine endometrioid adenocarcinoma, a mucinous adenocarcinoma of the gallbladder, and kin ovarian endometrioid carcinoma with a clear cell component. The progress of the patient until the time of death is discussed.
Coexisting endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia
(Wiley, 2004-01) Bilgin, Tufan; Özuysal, Sema; Ozan, Hakan; Atakan, Türkan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; 7004103925; 56616314600; 7003908072; 6504708479
Aim: To investigate the possibility of coexisting endometrial cancer (EC) in patients with atypical endometrial hyperplasia (AEH). Methods: Forty-six consecutive women who underwent hysterectomy for AEH were analyzed. Results: Final histopathological evaluation of hysterectomy specimens revealed EC in 11 patients (23.9%). Preoperative diagnosis of AEH was established by pipelle biopsy in eight patients and curettage was performed in the remaining patients. Of the patients with pipelle biopsy, two had a diagnosis of EC (25%), whereas nine women who underwent curettage, were further diagnosed as having EC (23.7%) (P > 0.05). Four (13.3%) of 30 women who had frozen sections at hysterectomy, were diagnosed with EC. Diagnosis of EC was missed in two patients (50%) at frozen section. In contrast, seven of 16 women (43.7%) who did not have frozen section, had EC. Conclusion: A relatively high incidence of EC is seen in patients with a diagnosis of AEH. Diagnostic results of pipelle biopsy and curettage were comparable. Frozen sections of hysterectomy specimens does not guarantee to exclude the possibility of EC, especially in patients with no myometrial invasion.
Comparison of early stage high grade serous primary fallopian tube cancers and epithelial ovarian cancers: A multicenter study
(Karger, 2017-01-30) Güngördük, Kemal; Özdemir, Aykut; Selçuk, İlker; Telli, Elçin; Toptaş, Tayfun; Akman, Levent; Güzel, Ahmet B.; Taşkın, Salih; Öge, Tufan; Güngördük, Özgü; Gökçü, Mehmet; Güngör, Tayfun; Yaşar, Levent; Terek, Mustafa C.; Özsaran, Aydın; Sancı, Muzaffer; Vardar, Mehmet A.; Meydanlı, Mehmet M.; Yalçın, Ömer T.; Ortaç, Fırat; Özalp, Sinan; Şahin, Öztürk; Ozan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Jinekolojik Onkoloji Anabilim Dalı.; 57193852253; 7003908072
Introduction: We compared the disease free-survival (DFS) and overall survival (OS) rates of patients with high-grade serous primary fallopian tube cancer (HG-sPFTC) and high-grade serous epithelial ovarian cancer (HG-sEOC). Methods: 22 early-stage cancer patients (International Federation of Gynecology and Obstetrics (FIGO) stages I-II) with HG-sPFTC were retrospectively evaluated. In addition, 44 control patients diagnosed with HG-sEOC were matched to these patients with respect to tumor stage at diagnosis. All patients underwent complete surgical staging, followed by adjuvant chemotherapy. Kaplan-Meier curves were used to generate survival data. Results: The mean age of HG-sPFTC patients was 59.4 +/- 6.2 years, and that of HG-sEOC patients 55.2 +/- 11.0 years (p = 0.002). All patients underwent 6 cycles of platinum-based adjuvant chemotherapy. All operations were optimal. The 5-year DFSs were 77.3% for HG-sPFTC patients and 75% for HG-sEOC patients (p = 1.00).The 5-year OS rates were 81.8% in women with HG-sPFTC and 77.3% in those with HG-sEOC (p = 0.75). Conclusion: The DFS and OS rates of patients with early-stage (FIGO stages I and II) HG-sPFTC and HG-sEOC were similar. The surgical and adjuvant therapy management of these malignancies should be similar.
Comparison of risk of malignancy index (RMI), CA125, CA 19-9, ultrasound score, and menopausal status in borderline ovarian tumor
(Taylor & Francis, 2012-06) Alanbay, İbrahim; Aktürk, Erhan; Çoksüer, Hakan; Ercan, Mutlu; Karaşahin, Emre; Dede, Murat; Yenen, Müfit Cemal; Başer, İskender; Ozan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; DKZ-4159-2022; 7003908072
Objective: The aim of this study was to assess the prognostic values of risk of malignancy index (RMI IV), ultrasound score, menopausal status, and serum CA125 and CA19-9 level in patients with borderline ovarian tumor (BOT). Methods: Fifty women having borderline ovarian tumor (BOT) and 5O individuals with benign adnexal mass were enrolled in this retrospective study. The sensitivity, specificity, positive predictive values, negative predictive values and diagnostic accuracy of preoperative serum levels of the CA125 and CA19-9, ultrasound findings and menopausal status, and RMI IV were calculated for prediction of discrimination between BOTs and benign adnexal masses and the results were compared. Results: The RMI IV was the best method for discrimination between BOTs and benign adnexal masses and was more accurate than the other parameters. When Receiver Operator Characteristic area under the curves for menopausal status was analyzed, serum CA 125 and CA19-9 level, ultrasound score, RMI IV(CA125), and RMI IV(CA19-9) were, 0.580, 0.625, 0.548, 0.694, 0.734 and 0.711, respectively. The best RMI IV cut-off was found to be 200 for discrimination of benign and BOT lesions. In the RMI formulation, replacing CA125 with CA19-9 didn't affect RMI IV sensitivity and specificity for discrimination. Conclusion: Compared to ultrasound, menopausal status, CA-125, CA19-9, the RMI IV was found to be the best predictive method for differentiation of BOTs from benign adnexal masses. RMI IV cut-off value of 200 is suitable for differentiation of benign and BOT's.
Comparison of risk of malignancy indices; RMI 1-4 in borderline ovarian tumor
(Imr Press, 2012) Yenen, Müfit Cemal; Aktürk, Erhan; Ozan, Hakan; Dede, Murat; Alanbay, İbrahim; Ercan, Cihangir Mutlu; Çoksuer, Hakan; Karaşahin, Kazım Emre; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0003-3457-4283; 0000-0002-5511-6938; W-6909-2019; A-3349-2017; 23670183700; 8941445200; 6503917949; 28367755400
Purpose: The aim of this study was to evaluate prognostic values of the risk of malignancy index (RMI)/1-4 in patients with borderline ovarian tumors (BOTs). Methods: The study consisted of 50 patients with BOT diagnosed and treated between 2005-2010 and 50 patients with benign adnexal massses between 2009-2010 as a control comparison group in the retropsective study. Preoperative serum CA125, U score, tumor size (S), and menopausal status were recorded. The RMI 1-3 was calculated according to the formula; UxMxCA125 and RMI 4 formulation was; UxMxCA125xS. S equaled 1 for tumor size < 7 cm and was 2 when size >= 7 cm. The RMI 1-4 indices were calculated for all patients together with the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy (DA). The performances of RMI indices were evaluated by McNemar's test and determined the best score cutoff value by the receiver operating characteristic (ROC) curve. Results: The mean age, median value of CA 125, ultrasound score, menopausal status, median values of RMI 1-4 of BOTs were statistically higher than benign adnexal masses. The sensitivity of RMI 1-4 was 26, 36, 62, and 60% at cutoff 200 level, respectively. The areas under curve of RMI 1-4 were found to be 0.676, 0.665, 0.668 and 0.734, respectively. DA of RMI 1-4 was found to be 56, 59, 50, and 71, respectively. When RMI 1-4 indices were compared with each other RMI 4 was the best RMI for BOTs. Conclusion: RMI 4 was the best predictive RMI for preoperative discrimination of BOT at a cutoff level of 200.
Comparison of tumor markers and clinicopathological features in serous and mucinous borderline ovarian tumors
(Imr Press, 2012) Alanbay, İbrahim; Aktürk, Erhan; Çoksüer, Hakan; Ercan, Cihangir Mutlu; Karaşahin, Kazım Emre; Dede, Murat; Yenen, Müfit Cemal; Dilek, Saffet; Ozan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 7003908072
Objective: The aim of this study was to assess tumor markers and clinicopathological findings of patients with serous and mucinous borderline ovarian tumor (BOT) features. Methods: The study consisted of 50 patients that were diagnosed with and treated for BOT between 2005- 2010 in three centers. CA125, CA19-9, and CA125+CA19-9 levels and clinicopathological features were compared in serous and mucinous histotypes. In serous and mucinous BOTs, correlations between tumor markers and demographics such as age, menopausal status, parity, clinical findings (stage, relapse, adjuvant chemotherapy, cytology, lymph node involvement and tumoral morphology (cystic-solid content, papilla, septation) were evaluated. Results: There were no significant differences between serous and mucinous tumors in the clinicopathological features such as stage, tumor markers, age, menopausal status, or cytology. In serous BOTs we found a significant relation between elevated CA 125+ CA 19-9, CA 19-9 and recurrence (p<0.05). Also there was a significant relation between elevated CA 125+ CA 19-9, CA 19-9 and cytology positivity (p<0.05). We found a significant relation in serous BOTs between elevated CA125+CA19-9, adjuvant chemotherapy and lymph node metastases (p<0.05). Also In mucinous BOTs with papilla formation we found a significant relation between elevated CA125 and CA 125+ CA19-9 (p<0.05). There was significant relation between cytology positivity and elevated CA 19-9 in mucinous BOTs (p<0.05). Conclusion: Serum tumor markers of serous and mucinous BOTs were different in relation to their clinicopathological features. This may reflect differences of serous and mucinous BOTs.
Dişi alt genital sisteminde helicobacter pylori prevalansı
(Uludağ Üniversitesi, 2006) Kaya, Tülay; Ozan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Helicobacter pylori, kronik gastritin önemli bir etkenidir. Günümüzde oral-oral, iyatrojenik (steril olmayan endoskopi, laringoskop ile) ve çevresel geçiş yolları tespit edilmesine rağmen H pylori'nin kesin geçiş yolları halabilinmemektedirServikal ortamın gastrik mukoza ortamına kolumnar epitel, ortamın pH'ı ve mukoid yapısı nedeniyle benzerliğinin bulunması, birçok jinekolojik veobstetrik patolojide H pylori'nin rolü olabileceğini düşündürmektedir. Bu mikro organizmanın literatürde henüz belirtilmemiş oral-genital ve fekal-genital yolla alt ve üst genital bölgeyi enfekte etmesi beklenebilir. H pylori'ninmide adeno kanseri ve midenin primer B hücreli lenfomasına (MALT) yol açtığı dikkate alındığında, servikal doku başta olmak üzere dişi genital sisteminde görülen patolojilerde olası rolünün araştırılması gereği bulunmaktadır. Bu çalışmada primer amacımız araştırmanın olası bir ilişkiyi ispatlaması halinde tıp literatürüne ve hastaların tedavisine katkıda bulunmak ve ekonomik fayda sağlamaktır. Çalışmaya Uludağ Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Polikliniğine müracaat eden pap smear sonuçları benign, ASCUS,ASC-H, LSIL, HSIL olarak gelen 35 olgu dahil edildi. H pylori'nin uterusun serviksindeki varlığı; fırça sitolojisi, histopatolojik yöntem ve serviko vajinal sekresyonda antijen saptamak için standardize edilmiş H pylori gaita antijen testi kullanılarak araştırıldı. Hastaların H pylori ile enfekte olup olmadığı serumda EL SA yöntemiyle H pylori IgG ve H pylori IgA antikoru bakılarak,aktif enfeksiyon varlığı gaitada H pylori antijen testi ile araştırıldı. Hastaların H pylori seroprevalansı %65.7 idi ve %17.1'inde aktif enfeksiyon mevcuttu. Kullandığımız tanı metotları ile H pylori'yi uterusun serviksinde, endoservikal mukus ve serviko vajinal sekresyonda saptayamadık. Çalışmanın sonucu göstermiştir ki uterusun serviksi H pyloriiçin rezervuar değildir ve H pylori fekal- genital bulaşmaz.
Drain-site metastasis observed following surgery and radiotherapy of an endometrial carcinoma figo stage ic patient: Case report
(Galenos Yayıncılık, 2008-03-01) Ozan, Hakan; Özdil, Murat; Özyürek, Eser Tefik; Özerkan, Kemal; Kıran, Beray; Aker, Sibel; OZAN, HAKAN; Özdil, Murat; Özyürek, Eser Tefik; ÖZERKAN, KEMAL; Kıran, Beray; Aker, Sibel; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; DKZ-4159-2022; AAH-9791-2021; JLF-4109-2023; INC-9610-2023; FDT-3930-2022; EJH-8721-2022
Endometrial carcinoma is the most prevalent malignancy of the genital tract. With early diagnosis and treatment, its prognosis is more favorable than other gynecological malignancies. The objective of this case study is to present a very rare condition of a drain site metastasis following the treatment of a low stage endometrial carcinoma.A 63 year old woman was operated for endometrial carcinoma (histological subtype: Endometrioid) FIGO Stage IC (Grade I) and treated with the brachytherapy protocol, postoperatively. During the routine postoperative follow-up exams every three months, she presented with a mass in the right lower abdominal quadrant located at the drain site in the 15th postoperative month. Biopsy sampling of this mass revealed metastatic endometrioid adenocarcinoma. Radiotherapy followed by chemotherapy and eventually surgery was planned forthe resection of the regressed mass.Similar metastatic lesions in gynecological cancers are mostly restricted to high stage ovarian and peritoneal malignancy conditions, and are usually located at trochar port sites and paracentesis puncture points. Nevertheless, this case shows that other early stage malignancies may as well metastasize in a similar fashion and should not be overlooked in the follow-up examinations.
Effect of prechemotherapy filgrastim on the bone marrow toxicity of topotecan
(IMR Press, 2001) Ozan, Hakan; Özkalemkaş, Fahir; Ozan, Ülkü; Özerkan, Kemal; Bilgin, Tevfik; Küçükyıldız, Faruk; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Hemotoloji Anabilim Dalı.; AAG-8495-2021; AAH-9791-2021; 7003908072; 6601912387; 6507254632; 6603345841; 7004103925; 6504371550
Purpose: To investigate the efficacy and safety of single-dose filgrastim administered 24 hours prior to chemotherapy in the prevention of topotecan-related myeloid suppression. Methods: No medication was given to 21 rats in group I; 1.5 mg/m(2)/day topotecan was administered intraperitoneally for five days every three weeks to 21 rats in group 11; a single dose of 5 mug/kg filgrastim was injected intraperitoneally 24 hours before the intraperitoneal administration of the same dose of topotecan to 21 rats in group M. After completion of six cycles of chemotherapy, the rats were decapitated and blood samples were immediately collected into citrated tubes for complete blood counts. Results: White blood cell and lymphocyte counts in the control and the filgrastim + topotecan groups were similar (p > 0.05) and significantly higher than the counts in the topotecan group (p < 0.05). There was no difference in means of neutrophil, monocyte, eosinophil, basophil and erythrocyte counts among the groups (p > 0.05). Conclusion: Filgrastim administration prior to chemotherapy seems to be beneficial and further investigations are needed.
Effect of progestogens on estrogen-induced lipoprotein changes
(Elsevier Science Bv, 1993) Tüfekçi, Mehpare; Zafer, Çolak; Ozan, Hakan; Kimya, Yalçın; Aydınlar, Ali; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı; 0000-0002-8974-8837; AAI-6632-2021
A study was performed to evaluate the role of progestogens, on estrogen-induced changes in lipoprotein levels. Sixty postmenopausal symptomatic women, aged 36-59, were included in the study. They were prospectively randomized to a sequential schedule (n = 20), 17beta-estradiol transdermally 0.05 mg/day on days 1-24 and medroxyprogesterone acetate 10 mg/day orally on days 15-24 or a continuous schedule (n = 20), 17beta-estradiol transdermally 0.05 mg/day and medroxyprogesterone acetate 2.5 mg/day orally on days 1-24. Patients who had total abdominal hysterectomy + bilateral salphingooopherectomy (n = 20) received only 17beta-estradiol 0.05 mg/day continuously. Serum total cholesterol (TC), high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and triglyceride (TG) levels were determined prior to and at the 3rd, 6th and 9th month of therapy in all groups. Mean TC, TG and LDL cholesterol levels did not change significantly during therapy (P > 0.05). Only the mean HDL cholesterol levels showed significant increases in all groups; from 42.30 +/- 9.97 mg/dl to 64.10 +/- 6.81 mg/dl in group I (P < 0.001), from 41.85 +/- 9.09 mg/dl to 60.65 +/- 7.41 mg/dl in group II (P < 0.001) and from 40.70 +/- 11.26 mg/dl to 58.80 +/- 7.74 mg/dl in group III (P < 0.001). It is concluded that medroxyprogesterone acetate, whether used continuously or sequentially, does not oppose the beneficial effects of transdermal 17beta-estradiol on the lipoprotein profile.
Endometrial karsinom ve endometrial intraepitelial neoplazilerde Wilms tümör 1 proteini ekspresyonu
(Uludağ Üniversitesi, 2011) Atik, Yeliz; Ozan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Son yıllarda yapılan çalışmalarda endometrial karsinom ve uterin sarkomlarda wilms tümör (WT) 1 proteini üretiminin fazla olduğu immünohistokimyasal ve genetik testlerle gösterilmiştir. Bu nedenle WT1 proteini endometrial karsinomlarda immünoterapi için düşünülen tümörle ilişkili proteinlerden biridir. Bu çalışma Endometrial İntraepitelyal Neoplazi (EİN) ve endometrial karsinomlarda WT1 proteini ekspresyonu düzeyinin gösterilmesini amaçlamaktadır.Çalışmada 30 endometrial adenokarsinom ve 20 endometrial intraepitelyal neoplazi olgusunda immunohistokimyasal olarak WT1 proteini ekspresyonu araştırıldı. Karşılaştırmak amacıyla proliferatif endometrium (n=7), sekretuar endometrium (n=9), atrofik endometrium (n= 9) ve benign endometrial polip (n=28) olguları da WT1 ekspresyonu açısından immunohistokimyasal olarak incelendi. Dokuların hücresel boyanma ve vasküler boyanması değerlendirildi.Çalışmamızda EİN vakalarında hücresel boyanma %100, vasküler boyanma %85, toplam boyanma %100 olarak saptanmıştır. Endometrioid adenokarsinom olgularında hücresel boyanma %66,6, vasküler boyanma %73,3, toplam boyanma %100 olarak saptanmıştır. Gruplar arasında hücresel boyanma pozitifliği açısından istatistiksel olarak anlamlı bir farklılık saptanmıştır (p=0,012).Gruplar arasında vasküler ve toplam boyanma açısından istatistiksel olarak anlamlı bir farklılık saptanmamıştır (p=0,608, p>0,05). Endometrioid adenokarsinom olgularında grade ve evre artışı ile vasküler, hücresel ve toplam boyanma artışı arasında anlamlı korelasyon saptanmamıştır.Sonuç olarak endometrioid adenokarsinom ve EİN olgularında yüksek WT1 boyanma oranları görülmektedir ve bu olgularda, tümör ilişkili antijen olan WT1 proteinini hedef alan immunoterapi uygulanabilir bir tedavi seçeneği olabilir.
Gebeliğe bağlı hipertansiyon olgularında serum laboratuar ölçümleri ve klinik tablo arasındaki ilişki
(Uludağ Üniversitesi, 1994-10-13) Uncu, Gürkan; Ozan, Hakan; Cengiz, Candan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
1988-1993 yılları asında, Uludağ Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniği de tedavi edilen 93 hafif, 46 ağır preeklampsi ve 56 eklampsi olgusu retrospektif olarak incelenmiş, maternal ve neonatal mortalite açısından önemli olan bu hastalık grubunda klinik tablo, gebeliklerin prognozu ve serum laboratuvar ölçümleri arasındaki ilişki aştırılmıştır. İdrardaki protein miktarı, eklampsi ve ağır preeklampsi grubunda, hafif preeklampsi grubuna göre anlamlı olarak yüksek bulunmuş ve idrardaki protein kaybı arttıkça klinik tablonun daha ağırlaştığı saptanmıştır. Kan trombosit düzeyleri gruplar arasında anlamlı farklılık göstermiş ve kan trombosit düzeyleri düştükçe klinik durumun ağırlaştığı sonucuna varılmıştır. Ortalama serum transaminaz ve ürik asit düzeyleri eklampsi grubunda, hafif ve ağır preeklampsi gruplarına göre anlamlı olarak daha yüksek bulunmuştur.
Gebeliğe bağlı hipertansiyon olgularında tiroid hormonları ve antitiroid antikorlar
(Uludağ Üniversitesi, 1995-11-29) Uncu, Gürkan; Kimya, Yalçın; Ozan, Hakan; Kadıoğlu, Murat; Daregenli, Ömer; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Gebeliğe bağlı hipertansiyon (GBH) olgularında, tiroid fonksiyonları ve antitiroid antikorları 22 olguda araştırılmış ve obstetrik özellikleri benzer 16 gebeden oluşan kontrol grubu ile karşılaştırılmıştır. GBH grubundaki gebelerin % 22.8 inde serbest triiodotironin (ST 3) ve total triiodotironin (TT 3) normal sınırların altında bulunmuştur. Ortalama serbest tiroksin (ST 4), TT 3 ve ST3 değerleri kontrol grubuna göre anlamlı olarak düşük bulunmuştur. Olguların hepsinde antitiroid antikorları negatif olarak saptanmıştır. Bu çalışmanın sonucunda, GBH olgularında ST3, TT3 ve ST 4 düşük, antitiroid antikorlar negatif olarak bulunmuştur.