Browsing by Author "Ocakoĝlu, Gökhan"

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Arterial dysfunction in early autosomal dominant polycystic kidney disease independent of fibroblast growth factor 23
(Iranian Soc Nephrolgy, 2014-11) Yıldız, Abdülmecit; Karaaǧaç, Kemal; Doğan, İbrahim; Gül, Bülent Cuma; Ersoy, Alparslan; Asiltaş, Burak; Ermurat, Selime; Doğan, Selda; Oruç, Ayşegül; Sağ, Saim; Ocakoĝlu, Gökhan; Aktaş, Nimet; Güllülü, Sümeyye; Güllülü, Mustafa; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-2589-8585; 0000-0002-0710-0923; 0000-0001-8404-8252; 0000-0003-2467-9356; HLG-6346-2023; I-7575-2015; AAH-5054-2021; AAH-4002-2021; ABE-4424-2022; AAW-9185-2020; A-7063-2018; 23988796000; 35612977100; 55858507600; 55371331300; 57197017096; 56399188100; 55134803100; 15832295800; 57204660708; 6602684544
Introduction. Recent studies report reduced vascular compliance and elevated levels of fibroblast growth factor 23 (FGF23) in patients with autosomal dominant polycystic kidney disease (ADPKD) and preserved kidney function. In the present study, we investigated the relationship between vascular compliance and FGF23 in patients in early phases of ADPKD. Materials and Methods. We studied 54 ADPKD patients with preserved kidney function and 24 healthy individuals. All participants underwent noninvasive pulse wave analysis in order to determine large arterial elasticity index (LAEI) and small arterial elasticity index (SAEI) using a modified Windkessel model. Levels of FGF23 in addition to several cardiovascular risk factors were evaluated. Linear regression analyses were performed to determine independent correlates of LAEI, SAEI, and FGF23. Results. In the ADPKD group, 33 patients were hypertensive and the remaining patients were normotensive. Serum FGF23 levels of both ADPKD groups were significantly higher than that in the controls. Both hypertensive and normotensive ADPKD patients had lower LAEI and SAEI levels compared to the controls. There was no significant correlation between vascular compliance parameters and FGF23 levels. Having ADPKD was independently associated with increased FGF23 levels and decreased SAEI. Conclusions. Fibroblast growth factor 23 was found substantially elevated and arterial compliance was found significantly decreased in early ADPKD patients regardless of hypertension. However, there was no significant correlation between FGF23 levels and arterial function parameters. Additional studies are required to determine possible mechanisms of these disturbances and cardiovascular effects of FGF23 in ADPKD patients.
Encapsulating peritoneal sclerosis in peritoneal dialysis patients after kidney transplantation
(Elsevier, 2018) Ayar, Yavuz; Ersoy, Alparslan; Ocakoĝlu, Gökhan; Güllülü, E.; Kağızmanlı, H.; Yıldız, Abdülmecit; Oruç, Ayşegül; Yavuz, Mahmut; Güllülü, Mustafa; Dilek, Kamil; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-0710-0923; 0000-0003-4607-9220; 0000-0003-4607-9220; HLG-6346-2023; GSE-0029-2022; AAH-5054-2021; AAH-5180-2021; AGF-0767-2022; O-9948-2015; 55860143300; 35612977100; 15832295800; 57201320805; 57201310907; 56256977500; 55133912100; 7006244754; 6602684544; 56005080200
Objective. Encapsulating peritoneal sclerosis (EPS) is a serious complication for patients with chronic kidney disease (CKD) who were treated with long-term peritoneal dialysis (PD). The risk of EPS was increased after kidney transplantation. In our study we evaluated risk factors for EPS patients after kidney transplantation who were treated before with PD. Materials and Methods. In our study, between January 2008 and August 2015, 47 PD patients (12 had EPS) who underwent kidney transplantation were analyzed. Age, gender, time of PD treatment, human leukocyte antigen (HLA) matching, cold ischemia time, kidney function (serum urea, creatinine, etc), comorbidities, immunosuppressive therapy, clinical features, and outcomes of PD patients were retrospectively evaluated in both groups. Results. Mean age was 42 (range, 25-60) years in EPS patients, versus 43 (range, 22-77) years without EPS (P = .798). Distribution of gender was similar in both groups (P = .154). The C-reactive protein levels (P < .001), number of patients with peritonitis (P = .001), length of time on PD (P < .001), and serum ferritin levels (P = .020) were higher in EPS patients. The immunosuppressive therapy was changed; tamoxifen and steroids were used after diagnosis in EPS patients. HLA matching was higher in the non-EPS group (P = .006). EPS was more often seen in patients who were treated with continuous ambulatory peritoneal dialysis (CAPD; 75%; P = .036). EPS was more often detected in cadaveric transplant recipients (83.3%; P = .024). High peritoneal transmittance rate was more identified in EPS (+) patients (P = .001). EPS was more often seen in patients who were treated with icodextrin-based regimens in PD before transplantation (91.7%; P = .037). The length of time on PD and high ferritin levels increased EPS 1.08 and 1.01, respectively (P = .036 and .049, respectively), in multivariate analysis. Conclusion. The length of time on PD, type of PD, PD regimens with icodextrin, episodes of peritonitis, and peritoneal transmittance in patients with CKD affect the development of EPS after transplantation.
A novel biphasic oral contrast solution for enterographic studies
(Lippincott Williams & Wilkins, 2013) Algın, Oktay; Evrimler, Şehnaz; Özmen, Evrim; Metin, Melike Ruşen; Ersoy, Osman; Karaoǧlanoǧlu, Mustafa; Arslan, Halil; Ocakoĝlu, Gökhan; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; AAH-5180-2021; 15832295800
Purpose: To compare the efficacy and patients' tolerance of a new mixed biphasic oral contrast solution with routine biphasic oral contrast agent in magnetic resonance (MR) enterography (MRE). Materials and Methods: Thirty-seven patients (group 1) had MRE with the new mixture, whereas 14 patients (group 2) had MRE with biphasic oral contrast agent (lactulose). Magnetic resonance enterography images were evaluated by 2 experienced radiologists. Each intestinal segment was evaluated for luminal distension (LD), distinction from the surrounding tissue (wall conspicuity), and the confidence of radiologist for evaluation of the specified segment (radiological evaluation confidence). Comparisons between the 2 groups were performed using the Mann-Whitney U test. Interrater and intrarater agreement values were obtained. In addition, patients' acceptability and tolerance were assessed. Results: The new mixture was more effective than the oral contrast agent used in group 2 for LD, wall conspicuity, and radiological confidence. The values of interrater and intrarater agreement in scoring LD, wall conspicuity, and radiological confidence were generally moderate. Conclusion: Our new mixture allowed good-quality enterographic images, and this solution was well tolerated by patients. In addition, this mixture is useful for evaluation of small bowels and colonic segments. We suggest the use of it for enterographic examinations.
Why do patients with minor complaints choose emergency departments and does satisfaction with primary care services influence their decisions?
(Cambridge Univ Press, 2017-11-19) Akpınar, Yakup; Demirci, Hakan; Budak, Ersin; Baran, Ayse Karalar; Candar, Ali; Ocakoĝlu, Gökhan; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Bölümü.; HLG-6346-2023; AAH-5180-2021; 15832295800
Aim: To identify the reasons why patients with minor complaints choose emergency departments (EDs) as a first contact of care and whether dissatisfaction with primary care services influences their decisions. Methods: In this study, a self-completed survey called EUROPEP was given to 535 outpatients who were admitted to the XXXXX Hospital in Bursa and examined in the green zone in July 2015. Patients were asked about their complaints and why they preferred EDs as a first contact of care. Results: EDs were the first contact of care in 87.8% of cases. In all, 9% of patients registered to family physicians who were working outside the city of Bursa. There was no relationship between patient satisfaction and the number of previous visits to EDs in last 12 months (P=0.09). The main reasons for admitting to the emergency services were feeling excessive pain (20.4%), perception of urgency (14.5%) and that the family doctor services were closed outside working hours (13.2%). The mean patient satisfaction with family practice offices was calculated to be 68.1%. Conclusions: The frequency of admission to EDs as a first contact of care was extremely high in the absence of a referral system. Patients who did not have family doctors in the settlement where they live put an extra burden on the EDs. Overall, patient satisfaction with their GPs did not influence the number of visits to EDs but accessibility remains a big challenge.
YouTube as a potential source of information on deep venous thrombosis
(Sage Puplications, 2017-09) Bademci, Mehmet Şenel; Yazman, Serkan; Güneş, Tevfik; Tayfur, Kaptanderya; Gökalp, Orhan; Ocakoĝlu, Gökhan; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; AAH-5180-2021; 15832295800
Background No work has been reported on the use of video websites to learn about deep vein thrombosis and the value of education using them. We examined the characteristics and scientific accuracy of videos related to deep vein thrombosis on YouTube. Methods YouTube was surveyed using no filter and the key words deep vein thrombosis' and leg vein clot' in June 2016. The videos evaluated were divided into three groups in terms of their scientific content, accuracy, and currency: useful, partly useful, and useless. Results Of the 1200 videos watched, 715 (59.58%) were excluded with the exclusion criteria. Although most of the videos uploaded (22.9%, n=111) were created by physicians, the number of views for website-based videos was significantly higher (p=0.002). When the uploaded videos were assessed in terms of their usefulness, videos from physicians and hospitals were statistically more useful than other videos (p<0.001). Conclusions For videos created by medical professionals to be of higher quality, we believe they should be more up-to-date and comprehensive, and contain animations about treatment modalities and early diagnosis in particular.