Browsing by Author "Koca, Süleyman Serdar"
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Item Body mass index does not affect response to rituximab in patients with rheumatoid arthritis: Results from turkbio registry(Wiley, 2017-10) Koca, Süleyman Serdar; Karataş, Ahmet; Öz, Burak; Can, Gerçek; Yazıcı, Ayten; İnanç, Nevsun; Cefle, Ayşe; Ertürk, Zeypen; Akar, Servet; Şenel, Soner; Birlik, Merih; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Romatoloji Anabilim Dalı.; CMF-4757-2022; AAG-8227-2021Publication Cigarette smoking does not affect treatment response to tofacitinib in rheumatoid arthritis(Wiley, 2018-09-01) Karataş, Ahmet; Öz, Burak; Dalkılıç, Ediz; Can, Gerçek; Pehlivan, Yavuz; Şenel, Soner; Yazıcı, Ayten; İnanç, Nevsun; Ertürk, Zeynep; Cefle, Ayşe; Akar, Servet; Koca, Süleyman Serdar; Birlik, Merih; Önen, Fatoş; DALKILIÇ, HÜSEYİN EDİZ; PEHLİVAN, YAVUZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bölümü; CMF-4757-2022; AAG-8227-2021Item Comparison of long term anti-tnf survival in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis; Data from Turkbio registry(Wiley, 2017-10) Can, Gerçek; Şenel, Soner; Akar, Servet; Solmaz, Dilek; Koca, Süleyman Serdar; İnanç, Nevsun; Atagündüz, Pamir; Yazıcı, Ayten; Cefle, Ayşe; Göker, Berna; Zengin, Berrin; Uslu, Sadettin; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; CMF-4757-2022; AAG-8227-2021Item Comparison of long term anti-tnf survival in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis; data from Turkbio registry(BMJ Publishing Group, 2018-06) Can, Gerçek; Şenel, Soner; Akar, Servet; Solmaz, Dilek; Koca, Süleyman Serdar; İnanç, Nevsun; Atagündüz, Pamir; Yazıcı, Ayten; Cefle, Ayşe; Göker, Berna; Zengin, Berrin; Uslu, Sadettin; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Romatoloji Bilim Dalı.; AAG-8227-2021Item Concomitant use of corticosteroids at the baseline does not affect the drug survival of abatacept in rheumatoid arthritis(BMJ, 2018-06) Koca, Süleyman Serdar; Öz, Burak; Karataş, Ahmet; Can, Gercek; Şenel, Soner; Yazıcı, Ayten; İnanç, Nevsun; Cefle, Ayşe; Ertürk, Zeynep; Akar, Servet; Göker, Berna; Birlik, Merih; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Yağız, Burcu; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Romatoloji Bilim Dalı.; AAG-8227-2021Item The effect of smoking on response to tumor necrosis factor-alpha inhibitor treatment in ankylosing spondylitis patients: results from the Turkbio registry(BMJ Publishing Group, 2018-06) Tuğsal, Handan Yarkan; Can, Gerçek; Çapar, Sedat; Zengin, Berrin; Kenar, Gökçe; Akar, Servet; Şenel, Soner; Koca, Süleyman Serdar; Tufan, Abdurrahman; Yazıcı, Ayten; İnanç, Nevsun; Ellidokuz, Hülya; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı.Item The effect of smoking on response to tumor necrosis factor-alpha inhibitor treatment in ankylosing spondylitis patients: results from the turkbio registry(BMJ Publishing Group, 2018-06) Tuğsal, H. Yarkan; Can, Gerçek; Çapar, Sedat; Zengin, Berrin; Kenar, Gökçe; Akar, Servet; Şenel, Soner; Koca, Süleyman Serdar; Tufan, Abdurrahman; Yazıcı, Ayten; İnanç, Nevsun; Ellidokuz, Hülya; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı.Item The effect of smoking on response to tumour necrosis factor-alpha inhibitor treatment in psoriatic arthritis patients: Results from the TURKBIO registry(Wiley, 2018-09) Yarkan, Handan; Kenar, Gökçe; Capar, Sedat; Can, Gerçek; Zengin, Berrin; Akar, Servet; Şenel, Soner; Koca, Süleyman Serdar; Tufan, Abdurrahman; Yüziçi, Ayten; İnanç, Nevsun; Ellidokuz, Hülya; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı.Publication Factors that may be associated with uveitis in patients with spondyloarthritis(Wiley, 2018-09-01) Kaşifoğlu, Timuçin; Bilge, Nazife Şule Yaşar; Kiraz, Sedat; Ertenli, İhsan; Küçükşahin, Orhan; Dalkılıc, Ediz; Bes, Cemal; Kanitez, Nilüfer Alpay; Atagündüz, Pamir; Coşkun, Belkıs Nihan; Yağız, Burcu; Koca, Süleyman Serdar; Çinar, Muhammed; Ateş, Aşkın; Akar, Servet; Gercik, Onay; Bakırlı, Duygu Ersözlü; Yazısız, Veli; Kimyon, Gezmiş; Tufan, Müge Aydın; Emmungil, Hakan; Mercan, Rıdvan; Bodakçı, Erdal; Öz, Burak; Akar, Zeynel Abidin; Karadağ, Ömer; Keleşoğlu, Bahar; Yılmaz, Sedat; İlgen, Ufuk; Pehlivan, Yavuz; Terzioğlu, Ender; Kılıç, Levent; Erten, Şükran; Taşçılar, Koray; Kalyoncu, Umut; DALKILIÇ, HÜSEYİN EDİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bölümü; CMF-4757-2022Item The IL-33 gene is related to increased susceptibility to systemic sclerosis(Springer Heidelberg, 2015-12-23) Koca, Süleyman Serdar; Kara, Murat; Alibaz-Öner, Fatma; Öztuzcu, Serdar; Yılmaz, Neslihan; Çetin, Gözde Yıldırım; Kısacık, Bünyamin; Özgen, Metin; Pamuk, Ömer Nuri; Direskeneli, Haner; Sayarlıoğlu, Mehmet; Onat, Ahmet Mesut; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; AAG-8227-2021; 13205593600Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both in vitro and in vivo settings; moreover, increased level of IL-33 has also been reported in patients with SSc. Therefore, the aim of the present study was to detect the potential association of IL-33 gene polymorphisms on the susceptibility of SSc. A total of 300 SSc patients and 280 healthy controls (HC) were enrolled in this multicentric preliminary candidate gene study. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms (SNPs) of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on real-time PCR. There was no significant difference in terms of the allelic distributions and minor allele frequencies of evaluated four IL-33 polymorphisms between the SSc and HC groups (P > 0.05 for all). Moreover, the genotypic distributions of rs1157505, rs11792633 and rs1929992 polymorphisms were not significantly different (P > 0.05 for all). However, CC genotype of rs7044343 SNP was significantly higher in the SSc group compared to the HC group (P = 0.013, OR 1.75, 95 % CI 1.12-2.72). This preliminary candidate gene study demonstrates that rs7044343 polymorphism of IL-33 gene is associated with the susceptibility to the SSc in Turkish population. It may be suggested that IL-33 gene may be a candidate gene to research in SSc.Publication Impact of obesity on drug survival of tofacitinib in patients with rheumatoid arthritis: Analysis from the Turkbio registry(Wiley, 2018-09-01) Babaoğlu, Hakan; Göker, Borna; İnanç, Nevsun; Birlik, Merih; Koca, Süleyman Serdar; Cefle, Ayşe; Dalkılıç, Ediz; Tufan, Abdurrahman; Yılmaz, Sema; Şenel, Soner; Akar, Servet; Akkoç, Nurullah; Önen, Fatoş; Gazel, Ummugülsüm; DALKILIÇ, HÜSEYİN EDİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi; CMF-4757-2022Item Impacts of Anti-TNF treatment on improvement in work place and household productivity in patients with psoriatic arthritis(Wiley, 2016-10) Karadağ, Ömer; Onat, Ahmet Mesut; Küçükşahin, Orhan; Kaşifoğlu, Timuçin; Kısacık, Bünyamin; Pamuk, Ömer Nuri; Yılmaz, Neslihan; Koca, Süleyman Serdar; Yazısız, Veli; Ocakcı, Pınar Talu; Sayarlıoğlu, Mehmet; Terzioğlu, Ender; Erten, Sükran; Kalyoncu, Umut; Dalkılıç, Ediz; Öksüz, Mustafa Ferhat; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; CMF-4757-2022; INW-5232-2023Publication Interim analysis of baseline characteristics and preferences of administration route of rheumatoid arthritis patients who are bio-naive or switched between advanced ra treatments; a multicenter, prospective, observational study(Wiley, 2018-09-01) Direskeneli, Haner; Karadağ, Ömer; Ateş, Aşkın; Tufan, Abdurrahman; İnanç, Nevsun; Koca, Süleyman Serdar; Çetin, Gözde Yıldırım; Akar, Servet; Çınar, Muhammet; Yılmaz, Sedat; Yılmaz, Neslihan; Dalkılıç, Ediz; Beş, Cemal; Özbalkan, Zeynep; Yılmazer, Bariş; Şahin, Ali; Ersözlü, Emine Duygu; Tezcan, Mehmet Engin; Şen, Nesrin; Keser, Gökhan; Tansoker, İlkan; Hacıbedel, Fatma Başak; Helvacıoğlu, Kerem; Günay, Levent Mert; DALKILIÇ, HÜSEYİN EDİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi; CMF-4757-2022Item Investigation of poor prognostic factors among rheumatoid arthritis patients in Turkbio registry(Wiley, 2017-10) İnanç, Nevsun; Ertürk, Zeynep; Özen, Gülşen; Koca, Süleyman Serdar; Can, Gerçek; Karataş, Ahmet; Yazıcı, Ayten; Cefle, Ayşe; Akar, Servet; Şenel, Soner; Öz, Burak; Akkoç, Nurullah; Direskeneli, Haner; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Anabilim Dalı.; AAG-8227-2021Item Investigation of poor prognostic factors among rheumatoid arthritis patients in Turkbio registry(BMJ Publishing Group, 2018-06) İnanç, Nevsun; Ertürk, Zeynep; Özen, Gülşen; Koca, Süleyman Serdar; Can, Gerçek; Karataş, Ahmet; Yazıcı, Ayten; Cefle, Ayşe; Akar, Servet; Şenel, Soner; Öz, Burak; Akkoç, Nurullah; Direskeneli, Haner; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı.; JHC-5173-2023; FQP-0451-2022Item Investigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosis(Springer, 2015-11-17) Yolbaş, Servet; Çetin, Gözde Yıldırım; Alibaz, Fatma Öner; Çağatay, Yonca; Yılmaz, Neslihan; Öztuzcu, Serdar; Dönmez, Salim; Özgen, Metin; Koca, Süleyman Serdar; Pamuk, Ömer Nuri; Sayarlıoğlu, Mehmet; Kısacık, Bünyamin; Direskeneli, Haner; Demiryürek, Abdullah Tuncay; Onat, Ahmet Mesut; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Bilim Dalı.; AAG-8227-2021; 13205593600Systemic sclerosis (SSc) is a disease characterized by inflammation, vascular abnormalities and fibrosis. The role of Rho/Rho-kinase pathway was demonstrated in the pathogenesis of fibrosis, inflammation and vascular abnormalities. This study was aimed to investigate the relation between SSc and Rho/Rho-kinase gene polymorphisms. The study included 339 patients with SSc and 302 healthy subjects who were apparently healthy and at similar age and gender. Genotype distributions and allele frequencies were detected by using Chi-square test or Fisher's exact Chi-square test between groups, and the haplotype analysis was applied using online program (SHEsis). Significant association was found in a polymorphism in the ROCK1 gene (rs35996865), a polymorphism in ROCK2 gene (rs10178332), a polymorphism in RhoA gene (rs2177268) and two polymorphisms in RhoC gene (rs11102522 and rs11538960) with SSc disease (p < 0.0022). In this study, association between SSc disease and Rho/Rho-kinase gene polymorphisms was investigated for the first time; significant associations between ROCK1, ROCK2, RhoA and RhoC gene polymorphisms and SSc disease were demonstrated. The results strongly suggest that this SNP may be an important risk factor for development of SSc. However, further validation of these findings in an independent cohort is necessary.Item Is there any difference in ra patients for methotrexate use vs. leflunomide use as a concomitant treatment with biological and targeted synthetic dmards in turkbio registry?(BMJ Publishing Group, 2018-06) İnanç, Nevsun; Özen, Gülşen; Yalçınkaya, Yasemin; Koca, Süleyman Serdar; Can, Gerçek; Karataş, Ahmet; Yazıcı, Ayten; Cefle, Ayşe; Tufan, Abdurrahman; Akar, Servet; Şenel, Soner; Öz, Burak; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı.; CMF-4757-2022; FQP-0451-2022Item Is there any difference in ra patients for methotrexate use vs. leflunomide use as a concomitant treatment with biological and targeted synthetic dmards in turkbio registry?(Wiley, 2017-10) İnanç, Nevsun; Özen, Gülşen; Yalçınkaya, Yasemin; Koca, Süleyman Serdar; Can, Gerçek; Karataş, Ahmet; Yazıcı, Ayten; Cefle, Ayşe; Tufan, Abdurrahman; Akar, Servet; Şenel, Soner; Öz, Burak; Akkoç, Nurullah; Önen, Fatoş; Dalkılıç, Ediz; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; CMF-4757-2022; AAG-8227-2021Publication Leflunomide as a concomitant dmard choice for the biological treatment era of rheumatoid arthritis(Wiley, 2018-09-01) Kimyon, Gezmiş; Kiraz, Sedat; Ertenli, İhsan; Küçükşahin, Orhan; Dalkılıç, Ediz; Beş, Cemal; Kanitez, Nilüfer Alpay; Kaşifoğlu, Timuçin; Emmungil, Hakan; Coşkun, Belkıs Nihan; Yağız, Burcu; Koca, Süleyman Serdar; Çınar, Muhammet; Ateş, Askin; Akar, Servet; Bakırlı, Duygu Ersözlü; Yazısız, Veli; Bilge, Nazife Şule Yaşar; Tufan, Müge Aydın; Mercan, Rıdvan; Karadağ, Ömer; Keleşoğlu, Ayşe Bahar; Gercik, Onay; Öz, Burak; Akar, Zeynel Abidin; Yılmaz, Sedat; Turan, Sezin; Pehlivan, Yavuz; Terzioğlu, Ender; Kılıç, Levent; Erten, Şükran; Tekgöz, Emre; Taşçılar, Koray; Kalyoncu, Umut; DALKILIÇ, HÜSEYİN EDİZ; COŞKUN, BELKIS NİHAN; YAĞIZ, BURCU; PEHLİVAN, YAVUZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Ramotoloji Bölümü; 0000-0003-0298-4157; JQW-5031-2023; AAG-7155-2021; AAG-8227-2021; CMF-4757-2022Publication Preferences of inflammatory arthritis patients for biological disease-modifying antirheumatic drugs in the first 100 days of the COVID-19 pandemic(TÜBİTAK, 2021-01-01) Kalyoncu, Umut; Pehlivan, Yavuz; Akar, Servet; Kaşifoğlu, Timuçin; Kimyon, Gezmiş; Karadağ, Ömer; Dalkılıç, Ediz; Ertenli, Ali İhsan; Kılıç, Levent; Ersözlü, Duygu; Beş, Cemal; Emmungil, Hakan; Mercan, Rıdvan; Ediboğlu, Elif Durak; Kanıtez, Nilüfer; Bilgin, Emre; Çolak, Seda; Koca, Süleyman Serdar; Gönüllü, Emel; Küçükşahin, Orhan; Coşkun, Nihan; Yağız, Burcu; Kiraz, Sedat; PEHLİVAN, YAVUZ; DALKILIÇ, HÜSEYİN EDİZ; COŞKUN, BELKIS NİHAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-3734-1242; 0000-0003-1372-1555; 0000-0001-5184-4404; 0000-0003-1185-5816; 0000-0002-2260-4660; 0000-0003-4995-430X; 0000-0002-6990-4206; W-7332-2019; AAK-7851-2021; AAD-5448-2019; AAZ-5845-2021; AAG-8227-2021; C-8092-2015; JQW-5031-2023; GZA-3287-2022Background/aim: To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and methods: A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6-9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of COVID-19, the rate of continuation on bDMARDs, the reasons for treatment discontinuation, if any, and the current general disease activity (visual analog scale, [VAS]). Results: A total of 1394 patients (493 RA [47.3% on anti-TNF] patients and 901 SpA [90.0% on anti-TNF] patients) were included in the study. Overall, 2.8% of the patients had symptoms suggesting COVID-19, and 2 (0.15%) patients had PCR-confirmed COVID-19. Overall, 18.1% of all patients (13.8% of the RA and 20.5% of the SpA; p = 0.003) discontinued their bDMARDs. In the SpA group, the patients who discontinued bDMARDs were younger (40 [21-73] vs. 44 years [20-79]; p = 0.005) and had higher general disease activity; however, no difference was relevant for RA patients. Conclusion: Although the COVID-19 was quite uncommon in the first 100 days of the pandemic, nearly one-fifth of the patients discontinued bDMARDs within this period. The long-term effects of the pandemic should be monitored.