Browsing by Author "Kansu, Emin"
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Item Incidence of aplastic anemia in Turkey: A hospital-based prospective multicentre study(Pergamon-Elsevier Science, 1997) Başlar, Zafer; Aktuğlu, Gülten; Bolaman, Zahit; Büyükkeçeci, Filiz; Gezer, Sedef; Kansu, Emin; Koçak, Rikkat; Ovalı, Ercüment; Ruacan, Şevket; Sargın, Deniz; Tüzüner, Nükhet; Ülkü, Birsen; Tunalı, Ahmet; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 6602797853The incidence of aplastic anemia among hospitalized adult patients was prospectively determined in this first study in Turkey, New cases of aplastic anemia among patients 14 years and older who were admitted to the study centers were included in a 3 year survey. Seventy-three patients fulfilled the diagnostic criteria, yielding a mean annual incidence rate of 1.14 cases in 10(3) admissions. The male-to-female ratio of the cases (1.6:1) differed from the almost equal ratio of the larger population of Turkey, The median age was 30 years and females were younger at diagnosis. The age distribution of the cases was different from that of the population; showing two incidence peaks in both sexes, The majority of the patients (89%) had severe disease.Item P-glycoprotein expression by technetium-99m-MIBI scintigraphy in hematologic malignancy(Soc Nuclear Medicine Inc, 1998) Kostakoğlu, Lale; Dicle, Güç; Canpınar, Hande; Kars, Ayşe; Kıratlı, Pınar; Hayran, Mutlu; Gündüz, Ufuk; Kansu, Emin; Alper, Eray; Uludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı.Our aim was to ascertain the relationship between the degree of Tc-99m-MIBI uptake and the level of p-glycoprotein (Pgp) expression determined by flow cytometry and reverse transcription-polymerase chain reaction (RT-PCR) techniques in patients with hematologic malignancy. Methods: A total of 21 samples (19 patients) were evaluated. Two patients had repeat studies after therapy. Thirteen samples were studied at the time of initial diagnosis and 8 during relapse after therapy. After MIBI imaging, either bone marrow aspiration or peripheral blood was obtained for flow cytometric and RT-PCR analyses, Flow cytometry was performed using two different antibodies. After the injection of 555 MBq MIBI, whole-body and pelvic spot images were acquired using a dual-head gamma camera, The uptake in the bone marrow was evaluated against the background (adjacent soft tissue) by both qualitative (scoring system) and quantitative (tm/bkg ratios) analyses, Results: For flow cytometry, the limit for Pgp overexpression was set at >15% Pgp-positive mononuclear bone marrow or peripheral blood cells. There was an inverse correlation between the levels of Pgp and MIBI imaging using both the qualitative (scoring system) and quantitative (tm/bkg ratios) analyses (p = 0.022), Mean values were statistically different between Pgp + and Pgp - groups for both qualitative and quantitative analyses (p = 0.009 and 0.024, respectively). For RT-PCR, there was statistical support toward a difference in the mean values between Pgp + and Pgp - groups by qualitative analysis (p = 0.061); however, no statistical difference was found between these two groups by quantitative analysis (p = 0.179), Conclusion: Based on the strong correlation between the imaging and flow cytometry and a statistical support toward the correlation between the imaging and RT-PCR, MIBI imaging may be used for the in vivo detection of Pgp in patients with hematologic malignancy.