Browsing by Author "ALP, ALEV"

Now showing 1 - 7 of 7

Correlation of femoral cartilage thickness and osteoporosis in female patients with knee osteoarthritis
(Galenos Yayıncılık, 2021-08-01) Özövez, Gamze Altuğ; Alp, Alev; Özövez, Gamze Altuğ; ALP, ALEV; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı; 0000-0002-3147-6357; 0000-0002-3904-5463; DML-7159-2022; EKZ-2544-2022
Objective: To evaluate the relationship between ultrasonographic femoral cartilage thickness and presence of concomitant osteoporosis in a group of female patients with knee osteoarthritis (OA).Materials and Methods: This study included 118 women with knee OA who visited our outpatient clinic. Demographic data were collected, radiologic grading using Kellgren Lawrence (K-L) scale, ultrasonographic femoral cartilage thickness (FCT) evaluation, pain intensity evaluation, disability evaluation using OA index [Western Ontario and McMaster Universities Osteoarthritis index (WOMAC)], quality of life measurement using Short Form-36 (SF-36) and bone density measurement using dual-energy X-ray absorptiometry (DXA) were conducted for each patient.Results: We found that 58 patients (median age: 64.5 years, range: 50-75) had osteoporosis (group 1) and 60 patients (median age: 62 years, range: 51-75) did not have osteporosis (group 2). Group 2 had higher body mass index (BMI) in addition to lower WOMAC, SF-36 physical function, physical role limitation, pain and social function scores. The severity of osteoporosis and K-L staging were negatively correlated. The DXA femoral neck and total lumbar T-scores were higher in the advanced stages of OA. FCT had no significant correlation with age, WOMAC index and SF-36 scores. Moreover, the left knee FCT was negatively correlated with BMI.Conclusion: Radiologic staging of OA had a negative correlation with osteoporosis but no significant correlation with the quantitative measurement of FCT using ultrasonography.
Evaluation of the relationship between proinflammatory cytokine levels and clinical findings of fibromyalgia syndrome
(Shiraz Inst Cancer Res, 2021-01-01) Ellergezen, Pınar; Alp, Alev; Çavun, Sinan; ELLERGEZEN, PINAR; ALP, ALEV; ÇAVUN, SİNAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı; AAC-9702-2019; ICM-4005-2023; EKZ-2544-2022
Background: Immune system has an important effect on pain related disorders such as fibromyalgia syndrome (FMS). There is no specific laboratory technique for the diagnosis of FMS, but measuring serum proinflammatory cytokines may help. Objective: The purpose of our study was to determine the serum levels of immune mediators and their relationship with FMS symptoms. Methods: 25 healthy individuals and 29 FMS patients receiving pregabalin 150 mg/day for a minimum of 3 months were included in this study. FMS patients were diagnosed according to diagnostic criteria of the American College of Rheumatology (ACR 2010). Widespread pain index (WSI), fatigue, waking unrefreshed, cognitive symptoms, somatic symptoms, and Fibromyalgia Impact Questionnaire (FIQ) scores were evaluated in patients with FMS. Serum levels of proinflammatory cytokines (IL-2, IL-6, IL 12, IL-17, IFN-gamma, TNF-alpha) were assessed using enzyme-linked immunosorbent assay (ELISA). Results: Proinflammatory cytokine levels were higher in the control group than patients with FMS (P<0.05). A positive correlation was found between age and WSI (P=0.037). In addition, a significant positive relationship was determined between IL-17 level and waking unrefreshed (P=0.049). There was no significant relationship between other cytokines and clinical findings. Conclusion: Lower proinflammatory cytokine levels identified in FMS patients may be related to pregabalin treatment, and there may be an impairment in the inflammatory response. On the contrary, IL-17 showed positive correlation with waking unrefreshed.
Kinesiophobia and related factors in fibromyalgia syndrome
(Galenos Yayıncılık, 2023-04-01) Ertem, Uğur; Alp, Alev; ERTEM, UĞUR; ALP, ALEV; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı; 0000-0003-2142-2264; AAD-2089-2021; EKZ-2544-2022
Objective: This study aimed to determine the kinesiophobia levels in female patients with fibromyalgia (FMS). In addition, we intended to search the factors associated with kinesiophobia in patients with FMS and to evaluate the effect of kinesiophobia on work outcomes in this patient population.Materials and Methods: Between January 2021 and May 2021, 50 female patients with FMS and 44 female patients with musculoskeletal pain but not meeting the diagnostic criteria for FMS were included in the study. Pain was evaluated using the numeric scale, kinesiophobia levels with the Tampa Scale for Kinesiophobia (TSK), and the work outcomes with a questionnaire form prepared by us.Results: The median TSK scores were 41,50 (21-61) in the FMS group and 37 (23-61) in the control group. TSK score was significantly higher in the FMS group (p=0.030). Pain scores (p<0.001), and symptom duration (p<0.001) were significantly associated with high levels of kinesiophobia. When multiple linear regression analysis was performed, it was found that body mass index (p=0.411) was not associated with kinesiophobia levels, whereas age (p<0.001) was associated with kinesiophobia levels. Increased levels of kinesiophobia in patients with FMS patients have been associated with worse work outcomes.Conclusion: Evaluating the level of kinesiophobia in patients with FMS and developing preventive strategies in the presence of kinesiophobia can provide useful information when creating a treatment program.
Magnetotherapy in hand osteoarthritis: A pilot trial
(Churchill Livingstone, 2013-12-01) Kanat, Elvan; Alp, Alev; Yurtkuran, Merih; ALP, ALEV; Yurtkuran, Merih; Uludağ Üniversitesi/Tıp Fakültesi/Fizik Tedavi ve Rehabilitasyon Bölümü; ABG-2019-2020; GLB-5791-2022
Objective: To evaluate the effectiveness of magnetotherapy in the treatment of hand osteoarthritis (HO).Methods: In this randomized controlled single-blind follow-up study, patients with HO were randomly assigned into 2 groups (G1 and G2). The subjects in G1 (n = 25) received 25 Hz, 450 pulse/s, 5-80G, magnetotherapy of totally 10 days and 20 min/day combined with active range of motion/strengthening exercises for the hand. G2 (n =25) received sham-magnetotherapy for 20 min/day for the same duration combined with the same hand exercises. Outcome measures were pain and joint stiffness evaluation, handgrip and pinchgrip strength (HPS), Duruoz and Auscan Hand Osteoarthritis Indexes (DAOI) and Short Form-36 Health Questionnaire (SF-36) administered at baseline, immediately after treatment and at the follow up.Results: When the groups were compared with each other, improvement observed in SF-36 Pain (p < 0.001), SF-36 Social Function (p = 0.030), SF-36 Vitality (p = 0.002), SF-36 General Health (p = 0.001), Pain at rest (p < 0.001), Pain at motion (p < 0.001), Joint stiffness (p < 0.001), DAOI (p < 0.001) were in favor of G1.Conclusions: Changes in pain, function and quality of life scores showed significant advantage in favor of the applied electromagnetic intervention in patients with HO.
Pregabalin inhibits proinflammatory cytokine release in patients with fibromyalgia syndrome
(Turkish League Against Rheumatism, 2023-06-01) Ellergezen, Pınar; ALP, ALEV; ELLERGEZEN, PINAR; ÇAVUN, SİNAN; Çavun, Sinan; Çelebi, Melih; ÇELEBİ, MELİH; Macunluoğlu, Aslı Ceren; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizik Tedavi ve Rehabilitasyon Anabilim Dalı.; 0000-0002-6802-5998; AAC-9702-2019; JFJ-7690-2023
Objectives: The main goal of the study was to investigate how pregabalin (PGB) affects proinflammatory cytokine release in patients with fibromyalgia syndrome (FMS).Patients and methods: This experimental research study was conducted with 85 female participants (mean age: 49.6 & PLUSMN;10.1 years; range, 30 to 73 years) between April 2020 and November 2020. Of the participants, 30 were FMS patients using PGB 150 mg/day for at least three months, 30 were FMS patients not using PGB, and 25 were healthy individuals. The detection of FMS was carried out according to the 2010 American College of Rheumatology diagnostic criteria. Levels of proinflammatory cytokines (interleukin [IL]-2, IL-6, IL-12, IL-17, interferon-gamma, and tumor necrosis factor-alpha) were measured by enzyme-linked immunosorbent assay.Results: Serum concentrations of proinflammatory cytokines were remarkably decreased in FMS patients using PGB (p<0.001) and were higher in patients with FMS not using PGB than in healthy subjects (p<0.001). The highest values of proinflammatory cytokines were found in the group of FMS patients not using PGB (p<0.001).Conclusion:These results indicate that PGB inhibits the release of proinflammatory cytokines, suggesting that it can be used as an anti-inflammatory agent in inflammatory cases.
The effectiveness of carpal bone mobilization accompanied by night splinting in idiopathic carpal Tunnel syndrome
(Bayınar Tıbbi Yayıncılık, 2015-03-01) Günay, Berna; Alp, Alev; Günay, Berna; ALP, ALEV; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; ABG-2019-2020; CRT-3055-2022
Objective: The aim of this study was to investigate the effectiveness of carpal bone mobilization (CBM) and night splinting and to compare it with night splinting as a control group in the treatment of Carpal Tunnel Syndrome (CTS).Methods: In the single-blind (assessor) prospective randomised controlled trial, a total of 40 patients with mild to moderate CTS were diagnosed by electroneuromyography (ENMG). In Group 1 (n=20), patients received CBM three times a week, total of 10 times, and used neutral volar wrist splint at night for 3 weeks. Patients in Group 2 (n=20) used only neutral volar wrist splint at night for 3 weeks. All of the patients were assessed at baseline and at the 3rd month with respect to pain intensity using a numerical rating scale (0-10), handgrip and pinchgrip strength, functional status and symptom severity using the Boston Carpal Tunnel Questionnarie (BCTQ), and ENMG measurements.Results: There were improvements in all of the clinical variables, distal sensory latancy, and sensory nerve action potentials of the median nerve in Group 1. In Group 2, there was improvement in only BCTQ symptom severity and night/day pain intensity at the 3rd month. Improvement in pinchgrip strength and BCTQ functional status were superior in Group 1 when compared with that in Group 2 at the 3rd month.Conclusion: Both of the treatment modalities may be recommended for symptomatic relief. However, CBM combined with splinting may be a better choice for functional and strength amelioration as a noninvasive alternative treatment modality in CTS.
The impact of whole body vibration therapy on spasticity and disability of the patients with poststroke hemiplegia
(Hindawi Ltd, 2018-01-01) ALP, ALEV; Alp, Alev; Efe, Bilge; Adalı, Mihriban; Bilgiç, Adnan; Türe, Sevda Demir; DEMİR TÜRE, SEVDA; Karabulut, Merve; Coşkun, Feyma; Günay, Selim Mahmut; Ertem, Uğur; ERTEM, UĞUR; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizik Tedavi ve Rehabilitasyon Anabilim Dalı.; 0000-0003-2142-2264; 0000-0002-7550-5244; ABG-2019-2020; AAD-2089-2021
Objective. To determine if whole body vibration therapy (WBV) effectively improves functional outcome in patients with poststroke hemiplegia. Materials and Methods. In this single-blind RCT, WBV group (n = 10) had 40 hz frequency/4 mm amplitude vibration during 5 minutes/session, 3 days a week, for a duration of 4 weeks. The control group (n = 11) had no vibration therapy for the same duration while standing on the same platform. Patients in both of the groups did 15 minutes of stretching and active range of motion exercises before the intervention. Outcome measures were Modified Ashworth Scale (MAS), Functional Independence Measurement (FIM), and Timed 10-Meter Walk Test (10 mWT). Results. Only 10 mWT improved at the 1st week (p = 0.002), 1st month (p < 0.001), and 3rd month (p < 0.001) in favor of the intervention group. There was positive correlation also between 10 mWT and ankle spasticity (p < 0.001, r = 0.931). Conclusion. This study suggests that WBV therapy may be a complementary therapy in gait rehabilitation and functional outcome of the patients with calf muscle spasticity.