Please use this identifier to cite or link to this item:
Title: Age-related histopathological changes in the cardiac conducting system in the Turkish population: An evaluation of 202 autopsy cases
Authors: Çomunoğlu, Cem
Çomunoğlu, Nil
Eren, Bülent
Tanrıöver, Özlem
Gündoǧmuş, Ümit Naci
Eren, Filiz
Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.
Türkmen, Nursel
Keywords: Anatomy & morphology
Conduction system
Forensic medicine
Issue Date: Aug-2012
Publisher: Via Medica
Citation: Çomunoğlu, C. vd. (2012). "Age-related histopathological changes in the cardiac conducting system in the Turkish population: An evaluation of 202 autopsy cases". Folia Morphologica, 71(3), 178-182.
Abstract: Background: Histopathological features of the cardiac conducting system (CCS) in the Turkish population have not been investigated previously. Material and methods: We examined CCS of 202 autopsy heart specimens dissected between the years 2004 and 2005 in Bursa Forensic Medicine Institution. Of the 202 cases from all age groups, 154 were males and 48 were females. Results: In our cases, an increase in fibrous and adipose tissue concordant with age, indicating an age-related nature, were detected. Fibrous and fatty tissue infiltration appeared at the age of 35. Fatty infiltration started between the ages 20 and 34 years at the sinoatrial node (SAN). There was no relationship between obesity and fatty tissue infiltration in SAN and atrioventricular node (AVN). In 4 cases calcification and in 19 cases inflammation was observed. Amyloid accumulation was not present. In 7 cases myocardial infarction not involving CCS was seen. In 1 case fibroelastoma was detected. Conclusions: In the Turkish population age-related fibrosis and fatty infiltration in CCS appeared at the age of 35 years and increased with age. Fatty infiltration in the SAN started at a younger age than that reported in the literature. In cases where the cause of death could not be determined, we could not detect lethal pathological features. However, we think that examination of the CCS will improve the quality of autopsy diagnosis.
ISSN: 0015-5659
Appears in Collections:Scopus
Web of Science

Files in This Item:
File Description SizeFormat 
Türkmen_vd_2012.pdf163.54 kBAdobe PDFThumbnail

This item is licensed under a Creative Commons License Creative Commons