Please use this identifier to cite or link to this item:
|Title:||Comparison of the serum erythropoietin levels in chemotherapy-naive and cisplatin-treated cancer patients|
|Authors:||Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.|
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı.
|Citation:||Arslan, M. vd. (2005). "Comparison of the serum erythropoietin levels in chemotherapy-naive and cisplatin-treated cancer patients". Neoplasma, 52(1), 43-45.|
|Abstract:||There are conflicting data about the effects of cisplatin on erythropoietin (EPO) response to anemia. Aim of our study was to investigate whether endogenous EPO response to anemia in cisplatin treated patients was insufficient in comparison to the anemic chemotherapy-naive cancer patients and non cancer patients with iron deficiency anemia. Patients who had hemoglobin (Hb) levels of less than 110 g/l were included in the study. Fifteen chemotherapy-naive cancer patients were enrolled in Group A. Group B consisted of 15 patients who had been treated with three cycles of cisplatin chemotherapy and then became anemic and in Group C were included 15 patients who had iron deficiency anemia, without any malignancy. The mean Hb values were not different between all groups (102.8 +/- 39.8 g/l, 103.1 +/- 2.5 g/l and 99.3 +/- 3.6 g/l in Group A, Group B and Group C, respectively). However, EPO levels were found to be significantly lower in Group A and Group B than Group C (29.63 +/- 9.09 mU/ml, 20.87 +/- 2.43 mU/ml and 85.38 +/- 25.72 mU/ml, respectively; p=0.017 Group A vs. Group C, p=0.005 Group B vs. Group C). No significant difference was found between Group A and B (p=0.917). Opposite the iron deficiency anemia, cancer anemia is associated with an inadequate EPO response to anemia and administration of cisplatin does not lead to it further deterioration.|
|Appears in Collections:||PubMed|
Web of Science
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.