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Title: Are there differences between serotonergic, noradrenergic and dual acting antidepressants in the treatment of depressed women?
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.
Eker, Salih Saygın
Kırlı, Selçuk
Akkaya, Cengiz
Cangür, Şengül
Sarandöl, Aslı
Keywords: Antidepressants
Norepinephrine reuptake inhibitor
Postmenopausal women
Selective serotonin
5-hydroxytryptamine(2a) receptors
Estrogen replacement
12-month prevalence
Treatment response
Issue Date: 2009
Publisher: Taylor & Francis
Citation: Eker, S. S. vd. (2009). "Are there differences between serotonergic, noradrenergic and dual acting antidepressants in the treatment of depressed women?". World Journal of Biological Psychiatry, 10(4), Part 2, 400-408.
Abstract: Background. This study aims to investigate if there is a differential outcome of serotonergic and noradrenergic antidepressant treatment and if menopausal status has an impact on antidepressant response in depressed women. Methods. Data of the 111 depressed women who were included and completed the previous four open-label studies where patients were evaluated six times during a 10-week period, were pooled in the current study. Each of the reboxetine, sertraline and venlafaxine groups consisted of 37 depressed women. Patients were also divided into two subgroups of age, determining the 44 years as the cut-off point representing the menopausal status. Results. No significant difference was observed in the percent change of Hamilton Depression Rating Scale-17 (HDRS) and remission rates among treatment groups. Percent changes in Clinical Global Impression-Severity of Illness scale (CGI-S) and response rates were in favour of venlafaxine group at week 10. Individual HDRS items 2, 3, 4, 5 and 6 demonstrated significant improvement in the sertraline group, whereas HDRS item 7 demonstrated significant improvement in the venlafaxine group. An early reduction in anxiety subscale was observed in the venlafaxine group. Menopausal status had no impact on the outcome measures. Conclusions. These results suggest that noradrenergic and serotonergic activity do not differ from each other in treating depressed women. However, serotonergic activity appears to be more prominent in some particular symptoms such as feelings of guilt, suicidal ideation and sleep. Also, menopause does not appear to affect antidepressants' benefit in depressed women.
ISSN: 1562-2975
Appears in Collections:Scopus
Web of Science

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