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Title: Interleukin-4 gene polymorphisms confer Behcet's disease in Turkish population
Authors: Özçimen, Ahmet Ata
Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji ve Romatoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.
Oral, Haluk Barbaros
Dilek, Kamil
Taşkapılıoğlu, Özlem
Bingöl, Ümit
Sarandöl, Aslı
Sarıcaoğlu, Hayriye
Yurtkuran, Merih M.
Yurtkuran, Mustafa Abbas
Keywords: Immunology
Ifn-gamma gene
Cd4(+) T-cells
Promoter polymorphisms
Japanese population
Cytokine production
Chinese population
Online databases
Issue Date: Jun-2011
Publisher: Wiley
Citation: Oral, H. B. vd. (2011). ''Interleukin-4 gene polymorphisms confer Behcet's disease in Turkish population''. Scandinavian Journal of Immunology, 73(6), 594-601.
Abstract: Several cytokine genes may play crucial roles in host susceptibility to Behcet's Disease (BD), because the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphisms. The association of the IL-4 and IL-4R alpha gene polymorphisms with the susceptibility to BD was investigated in this study. DNA samples were obtained from a Turkish population of 97 patients with BD and 76 healthy control subjects. All genotyping (IL-4 and IL-4R alpha) experiments were performed using PCR sequence-specific primers. When compared with the healthy controls, the frequency of IL-4 -1098 TG and -590 CT genotypes was higher in the patients with BD. Analysis of allele frequencies showed that IL-4 -1098 G and IL-4 -590 T alleles were more common in the patients with BD when compared with healthy controls. Also, IL-4 TTC and haplotypes were found to confer BD. Interestingly, we demonstrated that IL-4R alpha gene polymorphism seems to be associated with the Pathergy test positivity in patients with BD. Our data suggest that IL-4 gene promoter polymorphisms may affect susceptibility to BD and increase risk of developing the disease. However, in order to confirm and assess the association of IL-4 and IL-4R alpha gene polymorphisms with the BD, large cohort studies are needed.
ISSN: 0300-9475
Appears in Collections:Scopus
Web of Science

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