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Title: Adult-onset Langerhans cell histiocytosis confined to the skin
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
Aydoğan, Kenan
Tunalı, S.
Karadoğan, Koran S.
Adım, Sadiman Balaban
Turan, Hatice Nur
Keywords: Dermatology
Issue Date: 2006
Publisher: Wiley
Citation: Aydoğan, K. vd. (2006). ''Adult-onset Langerhans cell histiocytosis confined to the skin''. Journal of the European Academy of Dermatology and Venereology, 20(7), 890-892.
Abstract: Langerhans cell histiocytosis (LCH) is a clonal, pleo-morphic disease of unknown aetiology, with theaccumulation of local or disseminated atypical histiocyticcells staining positively for S-100 and CD-1a, and causingdamage in the bones, lungs, mucocutaneous structuresand endocrine organs.1 The condition is generally dia-gnosed in infancy and childhood, but onset in adulthoodcan occasionally occur. The eruption is usually diffuse ormanifests as part of a multisystemic disease, and up to 25–50% of patients with LCH will present initially with acutaneous rash.1–5 Cutaneous manifestations are hetero-genous and similar both in children and adults.1,2 LCHconfined to the skin is uncommon among reported casesof adults.2–8 We describe a rare case of adult-onset LCHpresenting as cutaneous lesions located symmetrically onthe scalp, groin and inframammarian areas, and review theliterature for previous adult cases of isolated cutaneousLCH.
ISSN: 0926-9959
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