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Title: Use of phosphatide precursors to promote synaptogenesis
Authors: Wurtman, Richard J.
Sakamoto, Toshimasa
Uludağ Üniversitesi/Tıp Fakültesi.
Cansev, Mehmet
Ulus, İsmail Hakkı
Keywords: Cognition
Alzheimer's disease
Dendritic spine
Synaptic membrane
P2Y receptors
Ctp-phosphocholine cytidylyltransferase
Plasma choline concentrations
Plus docosahexaenoic acid
Rat sympathetic neurons
Brain-barrier transport
Alpha-linolenic acid
Hamster ovary cells
Nutrition & dietetics
Issue Date: 2009
Publisher: Annual Reviews
Citation: Wurtman, R. J. vd. (2009). "Use of phosphatide precursors to promote synaptogenesis". Annual Review of Nutrition, 29, 59-87.
Abstract: New brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are depleted in Alzheimer's disease,as are some circulating compounds needed for synthesizing phosphatides, the major constituents of synaptic membranes. Animals given three of these compounds, all nutrients-uridine, the omega-3 polyunsaturated fatty acid docosahexaenoic acid, and choline-develop increased levels of brain phosphatides and of proteins that are concentrated within synaptic membranes (e.g., PSD-95, synapsin-1), improved cognition, and enhanced neurotransmitter release. The nutrients work by increasing the substrate-saturation of low-affinity enzymes that synthesize the phosphatides. Moreover, uridine and its nucleotide metabolites activate brain P2Y receptors, which control neuronal differentiation and synaptic protein synthesis. A preparation containing these compounds is being tested for treating Alzheimer's disease.
ISSN: 0199-9885
Appears in Collections:Scopus
Web of Science

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