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|Title:||Use of phosphatide precursors to promote synaptogenesis|
|Authors:||Wurtman, Richard J.|
Uludağ Üniversitesi/Tıp Fakültesi.
Ulus, İsmail Hakkı
Plasma choline concentrations
Plus docosahexaenoic acid
Rat sympathetic neurons
Hamster ovary cells
Nutrition & dietetics
|Citation:||Wurtman, R. J. vd. (2009). "Use of phosphatide precursors to promote synaptogenesis". Annual Review of Nutrition, 29, 59-87.|
|Abstract:||New brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are depleted in Alzheimer's disease,as are some circulating compounds needed for synthesizing phosphatides, the major constituents of synaptic membranes. Animals given three of these compounds, all nutrients-uridine, the omega-3 polyunsaturated fatty acid docosahexaenoic acid, and choline-develop increased levels of brain phosphatides and of proteins that are concentrated within synaptic membranes (e.g., PSD-95, synapsin-1), improved cognition, and enhanced neurotransmitter release. The nutrients work by increasing the substrate-saturation of low-affinity enzymes that synthesize the phosphatides. Moreover, uridine and its nucleotide metabolites activate brain P2Y receptors, which control neuronal differentiation and synaptic protein synthesis. A preparation containing these compounds is being tested for treating Alzheimer's disease.|
|Appears in Collections:||Scopus|
Web of Science
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