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Title: Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.
Güllülü, Mustafa
Akdağ, İbrahim
Kahvecioğlu, Serdar
Filiz, Gülaydan
Savcı, Vahide
Keywords: Urology & nephrology
AT receptor blocker
Aldosterone antagonism
Anti-thy 1.1
TGF beta
Issue Date: 2006
Publisher: Taylor & Francis
Citation: Güllülü, M. vd. (2006). ''Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well''. Renal Failure, 28(6), 509-514.
Abstract: Studies performed recently have determined that aldosterone has not only a major role in electrolyte and water balance and K excretion, but it also modulates myofibroblast growth in the heart and blood vessels and causes fibrosis. This study investigated the effects of aldosterone blockers in rats with anti-thy 1.1 nephritis, both on proliferation and fibrosis, by comparing it to an angiotensin receptor inhibitor valsartan. Rats with anti-thy 1.1 nephritis were randomly allocated to one of the three following groups of treatment: the control group ( group 1); those treated with the aldosterone receptor blocker spironolactone ( group 2); and those treated with the ATRB valsartan ( group 3). On day 7, the parameters of glomerular fibrosis [ transforming growth factor beta, TGF staining areas %], proliferation (Ki-67), and renal damage scores were determined. The TGF-beta and Ki-67 levels of control group were significantly more than the other two groups (p < 0.01). The TGF staining areas percentages were significantly decreased compared to control group. The artery, glomerular, and renal injury scores evaluated between the groups were found to be significantly decreased compared to control group. In line with previous studies, this study found that in anti-thy 1.1 mesangioproliferative glomerulonephritis, aldosterone blockage affected proliferation and fibrosis.
ISSN: 0886-022X
Appears in Collections:Web of Science

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