Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils
dc.contributor.author | Wurtman, Richard | |
dc.contributor.buuauthor | Cansev, Mehmet | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-2918-5064 | tr_TR |
dc.contributor.researcherid | M-9071-2019 | tr_TR |
dc.contributor.scopusid | 8872816100 | tr_TR |
dc.date.accessioned | 2022-08-11T07:32:22Z | |
dc.date.available | 2022-08-11T07:32:22Z | |
dc.date.issued | 2007-08-24 | |
dc.description.abstract | Synthesis of phosphatidylcholine, the most abundant brain membrane phosphatide, requires three circulating precursors: choline; a pyrimidine (e.g. uridine); and a polyunsaturated fatty acid. Supplementing a choline-containing diet with the uridine source uridine-5 '-monophosphate (UMP) or, especially, with UMP plus the omega-3 fatty acid docosahexaenoic acid (given by gavage), produces substantial increases in membrane phosphatide and synaptic protein levels within gerbil brain. We now compare the effects of various polyunsaturated fatty acids, given alone or with UMP, on these synaptic membrane constituents. Gerbils received, daily for 4 weeks, a diet containing choline chloride with or without UMP and/or, by gavage, an omega-3 (docosahexaenoic or eicosapentaenoic acid) or omega-6 (arachidonic acid) fatty acid. Both of the omega-3 fatty acids elevated major brain phosphatide levels (by 18-28%, and 21-27%) and giving UMP along with them enhanced their effects significantly. Arachidonic acid, given alone or with UMP, was without effect. After UMP plus docosahexaenoic acid treatment, total brain phospholipid levels and those of each individual phosphatide increased significantly in all brain regions examined (cortex, striatum, hippocampus, brain stem, and cerebellum). The increases in brain phosphatides in gerbils receiving an omega-3 (but not omega-6) fatty acid, with or without UMP, were accompanied by parallel elevations in levels of pre- and post-synaptic proteins (syntaxin-3, PSD-95 and synapsin-1) but not in those of a ubiquitous structural protein, beta-tubulin. Hence administering omega-3 polyunsaturated fatty acids can enhance synaptic membrane levels in gerbils, and may do so in patients with neurodegenerative diseases, especially when given with a uridine source, while the omega-6 polyunsaturated fatty acid arachidonic acid is ineffective. | en_US |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) R01 MH028783 | en_US |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) R37 MH028783 | en_US |
dc.identifier.citation | Cansev, M. vd. (2007). "Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils". Neuroscience, 148(2), 421-431. | en_US |
dc.identifier.endpage | 431 | tr_TR |
dc.identifier.issn | 03064522 | |
dc.identifier.issue | 2 | tr_TR |
dc.identifier.pubmed | 17683870 | tr_TR |
dc.identifier.scopus | 2-s2.0-34548430850 | tr_TR |
dc.identifier.startpage | 421 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.neuroscience.2007.06.016 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0306452207007993 | |
dc.identifier.uri | http://hdl.handle.net/11452/28171 | |
dc.identifier.volume | 148 | tr_TR |
dc.identifier.wos | 000249638100010 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pergemon-Elsevier Science | en_US |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Neuroscience | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Membrane phosphatide | en_US |
dc.subject | Essential fatty-acids | en_US |
dc.subject | Arachidonic acid | en_US |
dc.subject | Docosahexaenoic acid | en_US |
dc.subject | Eicosapentaenoic acid | en_US |
dc.subject | Synapse | en_US |
dc.subject | Uridine | en_US |
dc.subject | Alpha-linolenic acid | en_US |
dc.subject | Acyl-coa concentrations | en_US |
dc.subject | Coenzyme-A synthetase | en_US |
dc.subject | Rat-liver microsomes | en_US |
dc.subject | Alzheimer-disease | en_US |
dc.subject | Cdp-choline | en_US |
dc.subject | Pheochromocytoma cells | en_US |
dc.subject | Phospholipase A(2) | en_US |
dc.subject | Neurite outgrowth | en_US |
dc.subject.emtree | Cerebellum | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Brain cortex | en_US |
dc.subject.emtree | Brain membrane | en_US |
dc.subject.emtree | Brain region | en_US |
dc.subject.emtree | Brain stem | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Uridine phosphate | en_US |
dc.subject.emtree | Corpus striatum | en_US |
dc.subject.emtree | Degenerative disease | en_US |
dc.subject.emtree | Diet supplementation | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Pyrimidine derivative | en_US |
dc.subject.emtree | Gerbil | en_US |
dc.subject.emtree | Omega 3 fatty acid | en_US |
dc.subject.emtree | Feeding | en_US |
dc.subject.emtree | Hippocampus | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Synapse | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Protein expression | en_US |
dc.subject.emtree | Icosapentaenoic acid | en_US |
dc.subject.emtree | Synaptic membrane | en_US |
dc.subject.emtree | Treatment planning | en_US |
dc.subject.emtree | Beta tubulin | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Docosahexaenoic acid | en_US |
dc.subject.emtree | Phospholipid | en_US |
dc.subject.emtree | Membrane protein | en_US |
dc.subject.emtree | Phosphatidylcholine | en_US |
dc.subject.emtree | Postsynaptic density protein 95 | en_US |
dc.subject.emtree | Polyunsaturated fatty acid | en_US |
dc.subject.emtree | Protein | en_US |
dc.subject.emtree | Synapsin I | en_US |
dc.subject.emtree | Syntaxin 3 | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Uridine | en_US |
dc.subject.mesh | Brain | en_US |
dc.subject.mesh | Analysis of variance | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arachidonic acid | en_US |
dc.subject.mesh | Gerbillinae | en_US |
dc.subject.mesh | Brain chemistry | en_US |
dc.subject.mesh | Docosahexaenoic acids | en_US |
dc.subject.mesh | Drug combinations | en_US |
dc.subject.mesh | Eicosapentaenoic acid | en_US |
dc.subject.mesh | Nerve tissue proteins | en_US |
dc.subject.mesh | Phospholipids | en_US |
dc.subject.mesh | Synapses | en_US |
dc.subject.mesh | Uridine | en_US |
dc.subject.scopus | Choline Phosphate Cytidylyltransferase; Phosphatidylcholines; Citicoline | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |