Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins
Date
2000
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Pergamon-Elsevier Science
Abstract
Objectives: To assess the relationship between lipoprotein (a) [Lp (a)] and lipoprotein oxidation in patients with coronary artery disease (CAD). Design and methods: Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CAD and 70 non-CAD subjects. Results: In CAD patients with Lp (a) concentrations greater than or equal to 30 mg/dL; total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and apo B levels were significantly higher and lag-time and age were significantly lower than those of CAD patients with Lp (a) concentrations < 30 mg/dL. In non-CAD subjects with Lp (a) concentrations a 30 mg/dL; TC, LDL-C, and vitamin E levels were significantly higher and lag-time was significantly lower than those of non-CAD subjects with Lp (a) concentrations < 30 mg/dL. In CAD patients, Lp (a) correlated negatively with lag-time and positively with MDA levels. Lp (a) correlated negatively with lag-time and vitamin E levels in non-CAD subjects. Conclusions: We have shown that plasma apo B-containing lipoproteins of both CAD and non-CAD subjects with Lp (a) levels 30 mg/dL are more susceptible to in vitro oxidative modification than those of subjects with Lp (a) levels < 30 mg/dL. The relationship between Lp (a) and enhanced susceptibility of apo B-containing lipoproteins to oxidation, appears to support routine investigation of Lp (a).
Description
Keywords
Medical laboratory technology, Lipoprotein (a), Lipoprotein oxidation, Antioxidants, Coronary artery disease, Low-density-lipoprotein, Middle-aged men, Vitamin-e consumption, Heart-disease, Myocardial-infarction, Risk-factors, Elevated lipoprotein(a), Antioxidant vitamins, Predictive value
Citation
Serdar, Z. vd. (2000). "Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins". Clinical Biochemistry, 33(4), 303-309.