Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults
Date
2002-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Pergamon-Elsevier Science
Abstract
Objectives: This study tested whether continuous ambulatory peritoneal dialysis (CAPD) changes free or phospholipid-bound choline concentrations in serum or peritoneal dialysis fluid of patients with end stage renal disease (ESRD).
Design and methods: Serum and dialysate choline and phospholipid-bound choline were measured before, during and after 6 h CAPD.
Results: Serum choline concentrations were higher in patients with ESRD compared with age-matched controls. CAPD lowered serum choline concentrations significantly although it did not influence phospholipid-bound choline. Choline accumulated in the dialysate, reaching 28.4 +/- 2.7 muM in children and 18.2 +/- 1.4 muM in adults, during six hours CAPD; phospholipid-bound choline increased to 22.9 +/- 2.5 muM and 10.8 +/- 1.4 muM in children and adults, respectively. The total daily loss of choline into the dialysate was 181 +/- 20 mumoles in children and 260 +/- 18 mumoles in adults.
Conclusion: CAPD causes a substantial loss of choline into peritoneal dialysates and reduces serum choline concentrations significantly.
Description
Keywords
Choline, Phospholipid-bound choline, End stage renal disease, CAPD, Peritoneal dialysis, Rat corpus striatum, Acetylcholine-release, Parenteral-nutrition, Tyrosine-Hydroxylase, Plasma choline, Brain, Metabolism, Deficiency, Transport, Cytidine, Liver, Medical laboratory technology
Citation
Özarda, Y. vd. (2002). "Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults". Clinical Biochemistry, 35(4), 307-313.