The effect of taurine supplementation on oxidative stress in experimental hypothyroidism
Date
2006
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
The purpose of this study was to investigate the oxidative status in experimental hypothyroidism and the antioxidant effect of taurine supplementation. Forty male Sprague Dawley rats were randomly divided into four groups (group 1, control; group 2, control + taurine; group 3, propylthiouracil (PTU); group 4, PTU + taurine). Hypothyroidism was induced by giving 0.05% PTU in drinking water for 8 weeks. Taurine was supplemented in drinking water at a concentration of 1 % for 5 weeks. Plasma (p < 0.05), red blood cell (p < 0.01), liver (p < 0.001) and kidney tissue (p > 0.05) malondialdehyde levels were increased in the PTU group compared with those of the control rats and were decreased in the PTU + taurine group compared with the PTU alone group. No significant changes were observed in glutathione levels of kidney and liver in the PTU group, but taurine supplementation significantly increased the glutathione levels of these tissues. Paraoxonase and arylesterase activities were decreased in the PTU group while taurine supplementation caused no significant changes in paraoxonase and arylesterase activities. These findings suggest that taurine supplementation may play a protective role against the increased oxidative stress resulting from hypothyroidism.
Description
Keywords
Biochemistry & molecular biology, Cell biology, Taurine, Rat, Oxidative stress, Hypothyroidism, Serum, Paraoxonase, Skeletal-muscle, Enzyme-activities, Enzyme-activities, Liver-mitochondria, Thyroid-dysfunction, Antioxidant defense, Rat hepatocytes, Lipid-peroxidation, Hepatic glutathione synthesis
Citation
Taş, S. vd. (2006). ''The effect of taurine supplementation on oxidative stress in experimental hypothyroidism''. Cell Biochemistry and Function, 24(2), 153-158.