The effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy in brown layer chicks

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Date

2005-04

Authors

Sevimli, Alper
Uğuz, Cevdet

Journal Title

Journal ISSN

Volume Title

Publisher

Taylor & Francis

Abstract

The effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy were investigated. In this study, 175 1-day-old brown layer chicks were used. Throughout the study Group II ( vitamin A) received high doses of vitamin A ( 75 000 IU/kg), whereas Group I ( negative control), Group III ( positive control), Group IV ( pentoxyfylline) and Group V ( methylprednisolone) received normal levels of vitamin A in the diet. At the fifth week, the experimental Groups II, III, IV and V were injected with Freund's adjuvant intra-articularly to induce amyloid arthropathy. Group IV received pentoxyfylline and Group V received methylprednisolone ( 10 mg/kg, intramuscularly) once. Joint and blood samples were examined 13 weeks after the injections. The values in Groups I, II, III, IV and V, respectively, were as follows: amyloid arthropathy formation (%), 0, 100, 87, 76, 66; serum amyloid A (ng/ml), 1669/17, 607 +/- 40, 423 +/- 39, 342 +/- 27, 293 +/- 22; serum retinol (mu g/dl): 59.75 +/- 3.8, 42.72 +/- 3, 59.24 +/- 3.6, 102 +/- 9.1, 101.3 +/- 12.3; heterophil/lymphocyte ratio: 0.504, 0.75, 0.75, 0.087, 0.44. In conclusion, it was observed that vitamin A enhanced the development of amyloid arthropathy and there were positive associations between amyloidosis, increased levels of serum amyloid A and increased numbers of tissue infiltrating macrophages. Methylprednisolone had a more successful inhibitory effect on amyloid arthropathy than pentoxyfylline.

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Keywords

Acute-Phase Protein, Nf-Kappa-B, Retinoic acid, Precursor protein, Gene-expression, Phorbol ester, Interleukin-1, Activation, Inhibition, Binding, Veterinary sciences, Gallus gallus

Citation

Sevimli, A. vd. (2005). "The effects of vitamin A, pentoxyfylline and methylprednisolone on experimentally induced amyloid arthropathy in brown layer chicks". Avian Pathology, 34(2), 143-149.