Association of migraine-like headaches with schimke immuno-osseous dysplasia

Date

2005-07-01

Authors

Sloan, Emily A.
Elizondo, Leah I.
Huang, Cheng
André, Jean-Luc
Bogdanovic, Radovan
Cockfield, Sandra
Cordeiro, Isabel
Deschenes, Georges
Fründ, Stefan
Kaitila, Ilkka

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley

Abstract

Schimke immuno-osseous dysplasia (SIOD) is characterized by spondyloepiphyseal. dysplasia, nephropathy, and T-cell deficiency. SIOD is caused by mutations in the putative chromatin remodeling protein SAL&RCAL1. We report an 8-year-old boy with SIOD and recurrent, severe, refractory migraine-like headaches. Through a retrospective questionnaire-based study, we found that refractory and severely disabling migraine-like headaches occur in nearly half of SIOD patients. We have also found that the vasodilator minoxidil provided symptomatic relief for one patient. We hypothesize that these headaches may arise from an intrinsic vascular, neuroimmune, or neurovascular defect resulting from loss of SMARCAL1 function.

Description

Keywords

Migraine, Immunodeficiency, Skeletal dysplasia, Headache, Renal failure, Nephrotic syndrome, Immunoosseous dysplasia, Spondyloepiphyseal dysplasia, Disease, Genetics & heredity

Citation

Kılıç, S. Ş. vd. (2005). "Association of migraine-like headaches with schimke immuno-osseous dysplasia". American Journal of Medical Genetics Part A, 135A(2), 206-210.