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  • Item
    Observation of a Charged Charmoniumlike Structure in e+e- → π+π- J/ψ at √s=4.26 GeV
    (American Physical Society, 2013-06-17) Tapan, İlhan; Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Fizik Bölümü.; CCD-9486-2022; 8905787000
    We study the process e(+)e(-) -> pi(+)pi(-) J/psi at a center-of-mass energy of 4.260 GeV using a 525 pb(-1) data sample collected with the BESIII detector operating at the Beijing Electron Positron Collider. The Born cross section is measured to be (62.9 +/- 1.9 +/- 3.7) pb, consistent with the production of the Y(4260). We observe a structure at around 3.9 GeV/c(2) in the pi(+/-) J/psi mass spectrum, which we refer to as the Z(c)(3900). If interpreted as a new particle, it is unusual in that it carries an electric charge and couples to charmonium. A fit to the pi(+/-) J/psi invariant mass spectrum, neglecting interference, results in a mass of (3899.0 +/- 3.6 +/- 4.9) MeV/c(2) and a width of (46 +/- 10 +/- 20) MeV. Its production ratio is measured to be R = (sigma(e(+)e(-) -> pi(+/-) Z(c)(3900)(-/+) -> pi(+)pi(-) J/psi)/sigma(e(+)e(-) -> pi(+)pi(-) J/psi)) = (21.5 +/- 3.3 +/- 7.5)%. In all measurements the first errors are statistical and the second are systematic.
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    The neuroprotective effect of olanzapine
    (Amer Psychiatric Publishing, 2008) Ozan, Erol; Yuluğ, Burak; Bakar, Mustafa; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; 0000-0002-9704-6173; O-8322-2016; AAD-3930-2022; 6507583384; 26643051200
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    Effect of surface area during stabilization of electric arc furnace dusts from steel foundries
    (John Willey & Sons Ltd, 2008-10) Salihoğlu, Güray; Pinarli, Vedat; Uludağ Üniversitesi/Mühendislik Fakültesi/Çevre Mühendisliği Bölümü.; 8551769300; 8551769100
    This study examined the effect of waste particle size on stabilization performance of hazardous electric arc furnace dusts (EAM) from, steel foundries through the measurement of the temperature rise during hydration and heavy metals leaching. EAFD was characterized by using scanning electron microscopy (SF-M), X-ray diffraction (XRD), X-ray fluorescence (XRF), granulometry, and acid neutralization capacity (ANC) analysis. Portland cement was used to stabilize F-AM Two types of paste samples, with EAFD content varying between 0% and 50% by weight, were prepared. The first type contained original EAFD, and the second contained ground EAFD with increased surface area. The increase in the temperatures of the mixes was monitored during the hydration, reactions of the pastes. Ground EAFD yielded higher temperature rise rates than the original EAFD. Heavy metals leaching were determined by toxicity characteristics leaching procedure (TCLP). Pastes containing ground EAFD up to 50% yielded lower zinc and lead leaching than that of samples containing original EAFD. The results revealed that surface area of the EAFD may affect the stabilization performance and therefore care should be given to storage conditions at the foundries.
  • ItemOpen Access
    Removal of Pb(II) ions in fixed-bed column from electroplating wastewater of Bursa, an industrial city in Turkey
    (Hindawi, 2013-08-16) Kara, Ali; Üstün, Gökhan Ekrem; Solmaz, Seval Kutlu Akal; Demirbel, Emel; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.; Uludağ Üniversitesi/Mühendislik Fakültesi/Çevre Mühendisliği Bölümü.; 0000-0002-7126-6792; 0000-0003-2457-6314; AAH-1967-2021; AAG-6271-2019; AAG-8439-2021; ESF-6302-2022; 7102824859; 6602601167; 8630493800; 54681740300
    Removal of Pb(II) ions from electroplating wastewater of Bursa, an industrial city in Turkey, was investigated in fixed-bed column. The experiments were conducted to study the effect of important design parameters such as column bed height and flow rate. The breakthrough profiles were obtained in these studies. At a bed height of 14 cm and flow rate of 6 mL/min, themetal-uptake capacity of poly(ethylene glycol dimethacrylate-1-vinylimidazole) [poly(EGDMA-VIM)] beads for Pb(II) ions was found to be 90 mg/g. Bed Depth Service Time (BDST) model was used to analyse the experimental data and evaluate the performance of adsorption column. For various flow rates, adsorption capacity per unit bed volume (N-0) and adsorption rate constant (k(a)) are in the range of 2370-3560 mg/mL and 0.0225-0.0616 L/mg h, respectively. The saturated column was easily regenerated by 0.1M HNO3 and the poly(EGDMA-VIM) beads in fixed-bed column could be reused for Pb(II) ions removal.
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    Exposing nursing students to the marketing methods of pharmaceutical companies
    (Sage Publications , 2008-05) Sarıkaya, Özlem; Alıcı, Sevim Ulupınar; Bozkurt, Gülçin; Civaner, Murat; Uludağ Üniversitesi/Tıp Fakültesi/Deontoloji Anabilim Dalı.; 24075622600
    There is a strong association between reliance on the promotional activities of pharmaceutical companies and a generally less appropriate use of prescription drugs. Pharmaceutical companies direct some of their promotion towards health workers who do not have the authority to prescribe medicines, such as nurses in certain countries. The aim of this study was to determine the impact that exposure to the marketing methods of pharmaceutical companies has on judgments made by nursing students about health worker-pharmaceutical company relationships. A cross-sectional survey was carried out with 442 nursing students in Istanbul, Turkey. The exposure of students to the marketing methods of pharmaceutical companies, whether it be indirectly through observation or directly by first-hand experience, increases the probability that students will adopt rationales that underlie affirmative judgments of health worker-pharmaceutical company relationships. Based on the pervasiveness and ability of drug promotion to influence the perceptions of students, it is imperative that attempts be made to reduce its negative impact.
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    Simulation based decision-making for hospital pharmacy management
    (IEEE, 2008) Yurtkuran, Alkın; Emel, Erdal; Uludağ Üniversitesi/Mühendislik Fakültesi/Endüstri Mühendisliği Bölümü.; 0000-0003-2978-2811; 0000-0002-9220-7353; AAH-1410-2021; N-8691-2014; 26031880400; 6602919521
    Managing healthcare delivery systems plays an important role for healthcare providers in order to have high quality service performances. Inpatient pharmacy delivery systems are one of those that have a key role in hospital's service quality. Simulation is the best tool to analyze the hospital pharmacy operations due to their inherent complexity. In this article, a simulation model is developed based on data collected from a hospital in Turkey to analyze its pharmacy delivery system. In comparison to the baseline system, two different scenarios with varying factors are investigated, seeking to minimize drug delivery time to patients. The results presented here indicate the possibility for improved system performance.
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    Experimental investigation of optimum thermal performance and pressure drop of water-based Al2O3, TiO2 and ZnO nanofluids flowing inside a circular microchannel
    (Springer Netherlands, 2018-03) Topuz, Adnan; Engin, Tahsin; Erdoğan, Beytullah; Mert, Serdar; Yeter, Alper; Özalp, A. Alper; Uludağ Üniversitesi/Mühendislik Fakültesi/Makine Mühendisliği Bölümü.; 0000-0002-4976-9027; ABI-6888-2020; 6506131689
    This paper presents thermal performance and pressure drop characteristics of water-based nanofluids flowing through a horizontal circular microchannel under the constant surface temperature condition, experimentally. Al2O3 (13 nm), TiO2 (10-25 nm) and ZnO (18 nm) nanoparticles with 0.5, 0.7 and 1.0% volume concentrations were used in order to prepare nanofluid. The thermal conductivity and viscosity values needed for the calculations were obtained by measuring separately. For the experiments, the microchannels made by both the different materials (Stainless steel, PEEK) and the different inner diameter (400, 750, 1000 mu m) were tested for the different surface temperatures (283, 298, 313 K). In the tests, the nanofluids had the different inlet temperature (323-333 K), the volume flow rates (20, 35, 50 mL min(-1)) and the concentrations. Heat transfer rate, Nusselt number, pressure drop and friction factor results were calculated. The optimum conditions were determined by using Taguchi approach. The thermal performance and the pressure drop of the fluids were compared. The results showed that the best thermal performance was obtained for Al2O3 nanofluid with 1.0% vol. concentration. A heat transfer enhancement of 15.3% was achieved using nanofluid instead of deionized water as the base fluid. Moreover, it has been seen no considerable pressure drop.
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    Quality control of in vitro produced Heterorhabditis bacteriophora (Rhabditida: Heterorhabditidae) strains isolated from Turkey
    (Türkiye Entomoloji Derneği, 2013-07-03) Susurluk, İsmail Alper; Kongu, Yasemin; Ulu, Tufan Can; Uludağ Üniversitesi/Ziraat Fakültesi/Bitki Koruma Bölümü.; 0000-0003-3640-1474; AAG-7131-2021; B-6308-2011; FDH-5971-2022; 22036687000; 55901837300; 55955615200
    H.b. 6 (Antalya), H.b. 17 (Kirklareli), H.b. 10 (Adana), H.b. HIZ (Izmir), H.b. HSU (Sanliurfa) and H.b. 876 (canakkale) strains of Heterorhabditis bacteriophora Poinar, 1976 (Rhabditida: Heterorhabditidae), were produced with in vivo and in vitro mass production techniques. Effectiveness and reproduction capacities of the nematodes obtained from in vivo and in vitro cultures were compared in order to determinethe quality of in vitro productionThe difference in infectivity of the strains produced with in vivo and in vitro techniques was not statistically significant, except H.b. 6, which was lower in in vitro. Some in vitro produced strains had significantly higher reproduction capacity than in vivo strains but some strains were not significantly different as in vivo produced strains. It was generally detected that the in vitro cultured Turkish strains maintained their prerequisites on effectiveness and reproduction capacities as their quality control standards.
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    Laser-based light barrier
    (Optica Publishing Group, 2008-07-01) Musa, Eldar; Uludağ Üniversitesi/Mühendislik Fakültesi/Elektrik-Elektronik Mühendisliği Bölümü.; 24829989200
    Design methods of a light barrier consisting of a reciprocally placed transmitter-receiver system with a continuous directional light beam are considered. An optical diagram is designed. Usage of multiple lasers in the transmitter is proposed to form a rectangular detection area. A sequential pulsed driving method is used. A detection method to find the detectors blocked by an object existing in the detection area is proposed. Light barrier detection area determination, line laser placements, photodetector array design principles, a common operation principle of sequentially pulsed lasers, reaction time obtainment, a simplified diagram, the structure of the light barrier using two line lasers, and the time diagrams explaining the operation principle are given.
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    A comparison of energy use in organic and conventional tomato production
    (Wfl Publication, 2008) Turhan, Şule; Özbaş, Başak Canan; Rehber, Erkan; Uludağ Üniversitesi/Ziraat Fakültesi/Tarım Ekonomisi Bölümü.; 0000-0001-9155-8170; AAG-8086-2021; 15822717900; 15822920800; 6506098192
    The organic agriculture began in 1985-1986 production year in Turkey thanks to the fact that the companies in Europe demanded organic products and introduced this production technique to the producers. Organic farming was begun with traditional exportation crops such as raisins, dried fig, dried apricot, hazelnut, chickpea, beans, lentil, olive and olive oil. Tomato production is very important for Turkey in terms of both domestic consumption and exports. The total value of tomato exports of Turkey in 2004 is 109,563,000$ and it constitutes 25% of the total vegetable exports of Turkey in 2004. Organic tomato processed into tomato paste is one of the organic export products of Turkey. Energy auditing is one of the most common approaches of examining energy efficiency and environmental impacts of the production system. The energy consumption patterns in organic and conventional tomato production in Canakkale province of Turkey were investigated in this study. The findings of this study show that energy consumption in organic tomato production per decare is 40.7% and per ton 8% less than in conventional tomato production. The energy output-input efficiency ratio in organic tomato production (0.213) is higher than in conventional tomato production (0.197). While the direct and renewable energy consumption of organic production is higher, the indirect and non-renewable energy consumption is lower than in conventional production. Benefit/cost ratios for organic and conventional tomato production are 2.73 and 2.18. The results also imply that organic tomato production is more profitable for farmers compared to conventional production.
  • ItemOpen Access
    New insights on neuronal nicotinic acetylcholine receptors as targets for pain and inflammation: A focus on α7 nAChRs
    (Bentham Science Publishers, 2017-08-16) Flood, Pamela; Papke, Roger L.; Damaj, M. Imad; Bağdaş, Deniz; Gürün, Mine Sibel; Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi.; Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.; AAG-8716-2019; EOB-5882-2022; 15062425700; 55664349700
    Background: Nicotine and nicotinic acetylcholine receptors (nAChRs) have been explored for the past three decades as targets for pain control. The aim of this review is to introduce readers particularly to alpha 7 nAChRs in a perspective of pain and its modulation. Methods: Developments for alpha 7 nAChR modulators and recent animal studies related to pain are reviewed. Results: Accumulating evidences suggest that selective ligands for alpha 7 nAChRs hold promise in the treatment of chronic pain conditions as they lack many of side effects associated with other nicotinic receptor types. Conclusion: This review provides the reader recent insights on alpha 7 nAChRs from structure and function to the latest findings on the pharmacology and therapeutic targeting of these receptors for the treatment of pain and inflammation.
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    APECED in Turkey: A case report and insights on genetic and phenotypic variability
    (Academic Press , 2018-09) Fierabracci, Alessandra; Pellegrino, Marsha; Frasca, Federica; Betterle, Corrado; Kılıç, Sara Şebnem; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0001-8571-2581; AAH-1658-2021; 34975059200
    APECED is a rare monogenic recessive disorder caused by mutations in the AIRE gene. In this manuscript, we report a male Turkish patient with APECED syndrome who presented with chronic mucocutaneous candidiasis associated with other autoimmune manifestations developed over the years. The presence of the homozygous R257X mutation of the AIRE gene confirmed the diagnosis of APECED syndrome. We further performed literature review in 23 published Turkish APECED patients and noted that Finnish major mutation R257X is common in Turks. In particular, we assessed retrospectively how often the Ferre/Lionakis criteria would have resulted in earlier diagnosis in Finns, Sardinians and Turks in respect to the classic criteria. Since an earlier diagnosis could have been possible in 18.8% of Turkish, in 23.8% of Sardinian and 38.55% of Finnish patients we reviewed from literature, Ferre/Lionakis criteria could indeed allow in future earlier initiation of immunomodulatory treatments, if found effective in future studies.
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    Two-step passivation for enhanced InGaN/GaN light emitting diodes with step graded electron injectors
    (Academic Press, 2018-01) Sheremet, Volodymyr; Genç, Muhammet; Gheshlaghi, N.; Elçi, M.; Sheremet, Nina; Altuntaş, İsmail; Ding, Kai; Avrutin, V.; Özgür, U.; Morkoc, H.; Aydınlı, Atilla; Uludağ Üniversitesi/Mühendislik Fakültesi/Elektrik Elektronik Mühendisliği Bölümü.; ABI-7535-2020; 7005432613
    Enhancement of InGaN/GaN based light emitting diode performance with step graded electron injectors through a two-step passivation is reported. Perimeter passivation of LED dies with SiO2 immediately following ICP mesa etch in addition to conventional Si3N4 dielectric surface passivation leads to decrease in the reverse bias leakage current by a factor of two as well as a decrease in the shunt current under forward bias by an order of magnitude. Mitigation of the leakage currents owing to the two-step passivation leads to significant increase in the radiant intensity of LEDs by more than a factor of two compared to the conventional single step surface passivation. Further, micro-dome patterned surface of Si3N4 passivation layer allow enhanced light extraction from LEDs. (C) 2017 Elsevier Ltd. All rights reserved.
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    Robust synchronization of uncertain Markovian jump complex dynamical networks with time-varying delays and reaction–diffusion terms via sampled-data control
    (Elsevier , 2018-02) Ali, M. Syed; Yogambigai, J.; Zhu, Quanxin; Arik, Sabri; Özcan, Neyir; Uludağ Üniversitesi/Mühendislik Fakültesi/Elektrik Elektronik Mühendisliği Bölümü.; FSP-6686-2022; 7003726676
    This paper is concerned with the problem of robust synchronization of a class of complex dynamical networks with time-varying delays and reaction-diffusion terms. To reflect most of the dynamical behaviors of the system, the parameter uncertainties are considered. A sampled-data controller with m stochastically varying sampling periods whose occurrence probabilities are given constants is considered. The control objective is that the trajectories of the system by designing suitable control schemes track the trajectories of the system with sample-data control. It is shown that, through Lyapunov stability theory, the proposed sample-data controllers are successful in ensuring the achievement of robust synchronization of complex dynamical networks even in the case of uncertainity and Markovian jumping parameters. By utilizing the Lyapunov functional method, Jensen's inequality, Wirtinger's inequality and lower bounds theorem, we establish a sufficient criterion such that, for all admissible parameter uncertainties, the complex dynamical network is robustly synchronized. The derived criteria are expressed in terms of linear matrix inequalities that can be easily checked by using the standard numerical soft-ware. Illustrative examples are presented to demonstrate the effectiveness and usefulness of the proposed results.
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    Stress evolution of Ge nanocrystals in dielectric matrices
    (IOP Publishing, 2018-03-08) Bahariqushchi, Rahim; Raciti, Rosario; Kasapoǧlu, Ahmet Emre; Gür, Emre; Sezen, Meltem; Kalay, Eren; Mirabella, Salvatore; Aydınlı, Atilla; Uludağ Üniversitesi/Mühendislik Fakültesi/Elektrik-Elektronik Mühendisliği Bölümü.; ABI-7535-2020; 7005432613
    Germanium nanocrystals (Ge NCs) embedded in single and multilayer silicon oxide and silicon nitride matrices have been synthesized using plasma enhanced chemical vapor deposition followed by conventional furnace annealing or rapid thermal processing in N₂ ambient. Compositions of the films were determined by Rutherford backscattering spectrometry and x-ray photoelectron spectroscopy. The formation of NCs under suitable process conditions was observed with high resolution transmission electron microscope micrographs and Raman spectroscopy. Stress measurements were done using Raman shifts of the Ge optical phonon line at 300.7 cm(-1). The effect of the embedding matrix and annealing methods on Ge NC formation were investigated. In addition to Ge NCs in single layer samples, the stress on Ge NCs in multilayer samples was also analyzed. Multilayers of Ge NCs in a silicon nitride matrix separated by dielectric buffer layers to control the size and density of NCs were fabricated. Multilayers consisted of SiNy:Ge ultrathin films sandwiched between either SiO₂ or Si₃N₄ by the proper choice of buffer material. We demonstrated that it is possible to tune the stress state of Ge NCs from compressive to tensile, a desirable property for optoelectronic applications. We also observed that there is a correlation between the stress and the crystallization threshold in which the compressive stress enhances the crystallization, while the tensile stress suppresses the process.
  • ItemOpen Access
    Optical coherence tomography: Is really a new biomarker for alzheimer's disease?
    (Wolters Kluwer Medknow Publications, 2018) Poroy, Ceren; Yücel, Ahmet Ali; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; FWB-6443-2022; JYT-8379-2024; 56142133900; 7005217049
    Introduction: Retinal ganglion cell (RGC) degeneration was histopathologically proved previously in Alzheimer's disease (AD) patients. In this study, we aimed to determine RGC degeneration in vivo using optical coherence tomography (OCT) in AD. Methods: Twenty-one mild-to-moderate AD patients and 25 cognitively healthy age-matched controls were enrolled in this case-control prospective study. All participants underwent OCT examination to assess peripapillary retinal nerve fiber layer (RNFL) thickness, macular volume, and thickness. Results: Foveal thickness and volume were significantly higher in AD patients than controls (P = 0.023 and P = 0.024, respectively). Compared to controls, peripapillary RNFL and other macular region measurements of AD patients were not statistically different (for all P > 0.05). Discussion: Increased foveal thickness and volume can be associated with the pathological changes in the early stages of degeneration These results differ from previous studies, but still confirm retinal degeneration in AD. Conclusion: With further OCT studies on large populations, OCT will be in clinical use for early diagnosis of AD.
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    Use of 0.5% apraclonidine solution in evaluation of blepharoptosis
    (Lippincott Williams & Wilkins, 2008) Beden, Ümit; Yazıcı, Bülent; Uludağ Üniversitesi/ Tıp Falültes/Göz Hastalıkları Anabilim Dalı.; 0000-0001-8889-1933; AAA-5384-2020; 7005398015
    Purpose: To evaluate the effect of instillation of a specific alpha 2-adrenergic agonist, topical 0.5% apraclonidine solution, on upper eyelid position in patients with blepharoptosis. Methods: This Study included 45 eyelids of 35 adult patients with blepharoptosis. Of these, 37 eyelids had acquired ptosis and 8 had congenital ptosis. Palpebral fissure height and margin-reflex distance in the upper eyelid were measured before and after instillation of 0.5% apraclonidine, 2.5% phenylephrine, and both drugs. Results: After instillation of 2.5% phenylephrine, 0.5% apraclonidine, and both drugs, the mean increases in palpebral fissure height were 2.12 mm +/- 1.4 mm, 2.11 mm +/- 1.4 mm, and 2.26 mm +/- 1.3 mm, respectively, and the mean increases in margin-reflex distance were 1.93 mm +/- 1.2 mm, 1.89 mm +/- 1.3 mm, and 2.03 mm +/- 1.2 mm, respectively (p = 0.86 and p = 0.85). The apraclonidine solution did not alter the test results in 14 eyelids in which the phenylephrine test results were negative. Conclusions: Topical 0.5% apraclonidine solution can be as effective as topical 2.5% phenylephrine in elevating a ptotic upper eyelid, and may be used for preoperative evaluation of blepharoptosis. Combined use of both drugs may not provide any additional benefit.
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    Signal changes in the dentate nucleus and globus pallidus on unenhanced T1-weighted magnetic resonance images after intrathecal administration of macrocyclic gadolinium contrast agent
    (Lippincott Williams and Wilkins, 2018-09-01) Soylu, Esra; Öztürk, Kerem; Nas, Ömer Fatih; Hakyemez, Bahattin; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0001-9664-2347; 0000-0002-3425-0740; E-1228-2018; AAG-8561-2021; AAI-2318-2021; 57193199579; 51864050100; 6602527239
    Objectives: The aim of this study was to evaluate signal changes in the dentate nucleus and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images (T1 WI) in a cohort of patients who have received intrathecal macrocyclic ionic gadolinium-based contrast agent (GBCA) gadoterate meglumine. Materials and Methods: A group of 20 patients (male/female ratio, 8:12; mean age, 39.5 +/- 15.5 years) who had not received intravenous GBCA but had received an intrathecal macrocyclic ionic GBCA (plus baseline and an additional final magnetic resonance imaging [MRI] for reference) from 2012 to 2017 were retrospectively included in this institutional review board-approved study. Two radiologists inspected T1-weighted 2-dimensional spin echo (n = 7) and 3-dimensional isotropic turbo field echo (n = 13) images on a 3 T MRI system to conduct visual evaluation and quantitative analysis. Baseline and final examination signal intensity (SI) ratios were assessed across time by using the same pulse sequences. For visual analysis, SI changes on the GP, thalamus (Th), cerebellar peduncle (CP), and dentate nucleus (DN) were graded as a 3-point scale. For quantitative analysis, SI ratio differences between the baseline and final MR examinations were estimated for the DN-to-CP and GP-to-Th ratios. One-sample t tests were used to investigate whether they differed from 0. In addition, to investigate significant differences between the SI ratios for various pulse sequences, t tests were performed. The regression analysis was additionally used to find any correlation between SI ratio differences and various confounding variables including age, sex, or the mean interval between the baseline and final MR examinations. Results: The SI ratio differences did not deviate significantly from 0, neither for the DN/CP ratio (0.013 +/- 0.0584, P = 0.287) nor the GP/Th ratio (-0.0113 +/- 0.0546, P = 0.366). The DN-to-CP and GP-to-Th SI ratio differences did not significantly deviate from 0 in the patient groups in either of the imaging sequences (P > 0.05) as well. Age, sex, and the mean interval between examinations did not influence SI ratio differences between examinations (P > 0.05). Conclusions: Intrathecal macrocyclic GBCA administration was not associated with measurable T1 SI changes in the GP and DN as an indicator of brain gadolinium deposition detectable by MRI.
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    Giant magnetoresistance in electrochemical deposited CoFe/Cu multilayers depending on Fe concentration
    (Springer, 2017-11-28) Koçkar, Hakan; Tekgül, Atakan; Alper, Mürsel; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Fizik Bölümü.; 0000-0001-6737-3838; P-2124-2016; AAG-8795-2021; 37462175100; 7005719283
    Electrochemical deposition of CoFe/Cu multilayers were performed on Ti substrate from a single bath. 0.025, 0.05 and 0.1 M Fe concentration were used in electrolytes. The deposition potentials were selected - 1.5 V for magnetic layers and - 0.3 V for non-magnetic layers with respect to saturated calomel electrode. The current-time transients were obtained during the deposition process. The X-ray diffraction was used to define the structure of the multilayers. The multilayers were found to be face-centred cubic structure such as bulk Cu. Their lattice parameter and inter-planar distances values confirm this result. The magnetic measurements were performed at room temperature under 2 kOe external magnetic field. The results show that the saturation magnetization gradually increased from 27 to 50 emu/cm(3) with increasing 0.025 to 0.05 M Fe concentration in electrolyte, and in the multilayer prepared from the electrolyte containing 0.1 M Fe concentration, this value drastically decreased to 18 emu/cm(3). The magnetoresistance measurements were carried out in magnetic fields in the range of +/- 1.2 kOe. The high GMR value (18 %) and sensitivity (4.4 %/Oe) were obtained for this multilayer.
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    What have we learned from Turkish familial hypercholesterolemia registries (A-HIT1 and A-HIT2)?
    (Elsevier Ireland, 2018-10) Yeşilbursa, Dilek; Sağ, Saim; Gül, Özen Öz; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0001-8404-8252; EHA-0046-2022; AAW-9185-2020; AAI-1005-2021; 36658194500; 12140008100; 26040787100
    Background and aims: Familial hypercholesterolemia (FH) is a common genetic disease of high-level cholesterol leading to premature atherosclerosis. One of the key aspects to overcome FH burden is the generation of largescale reliable data in terms of registries. This manuscript underlines the important results of nation-wide Turkish FH registries (A-HIT1 and A-HIT2). Methods: A-HIT1 is a survey of homozygous FH patients undergoing low density lipoprotein (LDL) apheresis (LA). A-HIT2 is a registry of adult FH patients (homozygous and heterozygous) admitted to outpatient clinics. Both registries used clinical diagnosis of FH. Results: A-HIT1 evaluated 88 patients (27 +/- 11 years, 41 women) in 19 centers. All patients were receiving regular LA. There was a 7.37 +/- 7.1-year delay between diagnosis and initiation of LA. LDL-cholesterol levels reached the target only in 5 cases. Mean frequency of apheresis sessions was 19 +/- 13 days. None of the centers had a standardized approach for LA. Mean frequency of apheresis sessions was every 19 +/- 13 (7-90) days. Only 2 centers were aware of the target LDL levels. A-HIT2 enrolled 1071 FH patients (53 +/- 8 years, 606 women) from 31 outpatients clinics specialized in cardiology (27), internal medicine (1), and endocrinology (3); 96.4% were heterozygous. 459 patients were on statin treatment. LDL targets were attained in 23 patients (2.1% of the whole population, 5% receiving statin) on treatment. However, 66% of statin-receiving patients were on intense doses of statins. Awareness of FH was 9.5% in the whole patient population. Conclusions: The first nationwide FH registries revealed that FH is still undertreated even in specialized centers in Turkey. Additional effective treatment regiments are urgently needed.