Browsing by Author "Yurtkuran, Mustafa Abbas"
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Item Angiotensin-II receptor antagonist losartan reduces micro albuminuria in hypertensive renal transplant recipients(Wiley, 2002-06) Alparslan, Ersoy; Dilek, Kamil; Usta, Mehmet; Yavuz, Mahmut; Güllülü, Mustafa; Yurtkuran, Mustafa Abbas; Oktay, Burçin; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; 35612977100; 56005080200; 7005030712; 7006244754; 6602684544; 6602172127; 7003389525In recent years, it has been demonstrated that losartan lowers macroproteinuria in diabetic or non-diabetic renal transplant recipients (RTx) similar to angiotensin converting enzyme (ACE) inhibitors. Microalbuminuria (MAU) may reflect subclinical hyperfiltration damage of the glomerulus. It could be a marker of kidney dysfunction in renal transplantation. The aim of the study was to assess the efficacy of losartan in hypertensive RTx with MAU. This study was conducted in 17 (M/F: 4/13) stable RTx. No change was made in the medical treatment of the patients. All cases received 50 mg/day losartan therapy for 12 wk. Renal functions and MAU were determined 12 and 6 wk and just before the treatment as well as sixth and twelfth week of the treatment in all patients. Losartan satisfactorily lowered systemic blood pressure. A significant reduction in MAU was observed from 103 +/- 53 mug/min at the beginning to 59 +/- 25 mug/min in the sixth week and 47 +/- 24 mug/min in the twelfth week (p = 0.0007 and 0.0005, respectively). From the sixth week of the treatment, the therapy significantly decreased hemoglobin, hematocrit and erythrocyte levels but did not change mean leukocyte and platelet counts, urea, creatinine levels and creatinine clearances. No serious side-effect was observed,during the study. In conclusion, we found that losartan decreased MAU in hypertensive RTx. For that reason, it might be considered as the first choise antihypertensive agent for the renoprotection in selected patients.Item Anti-proteinuric effect of angiotension II receptor antagonist losartan in cases with glomerular lesions(Dustri, 2001-03) Usta, Mehmet; Dilek, Kamil; Yavuz, Mahmut; Ersoy, Alparslan; Güllülü, Mustafa; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; 7005030712; 56005080200; 7006244754; 35612977100; 6602684544; 7003389525Item Arterial elasticity measurement in renal transplant recipients(Elsevier Science Inc, 2007-07) Yıldız, Abdülmecit; Fazlıoğlu, Murat; Ersoy, Alparslan; Güllülü, Mustafa; Güllülü, Sümeyye; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; 56256977500; 23988764000; 35612977100; 6602684544; 57204660708; 7003389525Arterial distensibility is reduced in chronic kidney disease (CKD) and after kidney transplantation. Pulse counter analysis provides an assessment of compliance or elasticity of the large conduit arteries (C1) and small arteries (C2). Decreased compliance has been shown to be predictive of primary coronary events in CKD patients. The aim of the present study was to compare elasticity measurements in hemodialysis (HD) patients, renal transplant recipients (RTR), and healthy subjects whose coronary angiographies were without lesion. Twenty-three RTRs, 18 HD patients, and 20 healthy subjects were included in the study. Pulse wave analysis was used to determine large and small vessel compliances. The C1 and C2 levels were significantly lower in HD patients compared with recipients and healthy subjects. Recipients showed lower C2 level compared with healthy subjects. There was no difference in C1 and C2 measurements between recipients receiving tacrolimus versus cyclosporine. Transplantation improves large and to some extend small artery elasticities in CKD patients.Item Changes of plasma free choline and choline-containing compounds' concentrations and choline loss during hemodialysis in ESRD patients(Pergamon-Elsevier Science, 2002-05) Özarda, Yeşim; Dilek, Kamil; Yurtkuran, Mustafa Abbas; Ulus, İsmail Hakkı; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; AAL-8873-2021; D-5340-2015; 55665181500; 56005080200; 7003389525; 7004271086Objectives: This study was undertaken to determine the changes in plasma free choline and choline-containing compounds in end stage renal disease (ESRD) and to determine if they were lost into the dialysate during hemodialysis. Design and methods: Plasma and dialysate free choline, phosphocholine and phospholipid, phosphatidylcholine-, sphingomyelin-bound choline were measured before, during and after hemodialysis. Results: Plasma free and bound choline concentrations (mean +/- standard error of the mean) were 12.9 +/- 0.6 and 2697 +/- 57 muM or 37.3 +/- 0.9 and 2792 +/- 98 muM in controls or in ESRD patients, respectively. Free choline concentrations were correlated (r = 0.598 p < 0.001) with the time the patients were subjected to hemodialysis. Plasma free choline and phosphocholine concentrations a-re decreased by a total of -8.1 +/- 0.6 μmol/L and -88 +/- 8 μmol/L, respectively: phospholipid- phosphatidylcholine- and sphingomyelin-bound choline are increased, during hemodialysis. Patients lost about 350 μmoles of choline into the dialysate during hemodialysis. Conclusion: Plasma free choline concentrations are elevated in ESRD. and a considerable amount of choline is lost into the hemodialysate.Item Comparison of higher dose of losartan treatment with losartan plus carvedilol and losartan plus ramipril in patients with glomerulonephritis and proteinuria(Taylor & Francis Ltd, 2007) Kahvecioğlu, Serdar; Akdaǧ, İbrahim; Güllülü, Mustafa; Arabul, Mahmut; Ersoy, Alparslan; Dilek, Kamil; Yavuz, Mahmut; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; 55956719500; 8342488100; 6602684544; 15925230900; 35612977100; 56005080200; 7006244754; 7003389525Background. Proteinuria may cause a worsening of accompanying renal disease or even lead to glomerulosclerosis. There is no data about the effect of carvedilol on patients with proteinuric (> 0.5 g/day) glomerulonephritis. This study aimed to compare the effects of carvedilol with ramipril and losartan in patients with proteinuric glomerulonephritis. Methods. Twenty-one glomerulonephritis patients were followed for 12 months. Patients were divided into three groups. All patients were treated with losartan 50 mg once daily for two weeks. After two weeks (baseline), patients were given additional medications: 50 mg losartan, 5 mg ramipril, and 25 mg carvedilol were given additionally to the patients in groups 1, 2, and 3 respectively. Results. Baseline mean proteinuria values of patients in groups 1, 2 and 3 were 1.6 +/- 1.1 g/day, 2.1 +/- 1.3 g/day, and 1.4 +/- 1.2 g/day, respectively. These values decreased to 0.5 +/- 0.7 g/day, 0.6 +/- 0.7 g/day, and 0.9 +/- 0.9 g/day, respectively, at the end of the 12(th) month. These results were statistically significant only in group 1 (p = 0.04). The rational variation of proteinuria between the first and 12(th) month of losartan, ramipril, and carvedilol were -61%, -62%, and -27%, respectively. The decreases in blood pressures between baseline and the first, sixth, and twelfth-month measurements were significant in all groups. Conclusions. Thee results showed that angiotensin-converting enzyme inhibitors (ACEls) and angiotensin receptor blockers (AT1ras) provide marked decreases in proteinuria, making their use indisputable in patients with glomerulonephritis. Carvedilol was not found to be as effective as ACEIs and AT1ras in decreasing proteinuria and preserving renal function.Item Cytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings(Clinical & Exper Rheumatology, 2009) Özçimen, Ahmet Ata; Dilek, Kamil; Sancaoğlu, Hayriye; Saba, Davit; Yücel, Ali; Yurtkuran, Mustafa Abbas; Yurtkuran, Merih; Oral, Haluk Barbaros; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji ve Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; 0000-0003-0463-6818; K-7285-2012; 56005080200; 35485529800; 55987378200; 57225839918; 55408539300; 7003389525; 7004498001The association of the cytokine gene polymorphisms with the development of Behcet's Disease (BD) was investigated in this study. DNA samples were obtained from a Turkish population of 97 unrelated patients with BD, and 12 7 unrelated health), control subjects. All genotyping (IL-6, IL10, IFN-gamma, TGF-beta 1 and TNF-alpha) experiments were performed using sequence-specific primers PCR. The frequency of TGF-beta 1 codon 25 GG genotype was found significantly lower in BD patients compared to healthy control subjects. The IL-10 -1082 GA genotype was more frequent whereas the AA genotype was less common in the BD group compared to the control group. The association between clinial findings and cytokine gene polymorphisms was further investigated in the patients with BD. The frequency of IFN-gamma AA genotype was lower in the patients with genital ulcer. Additionally, it was found that the frequency of IL-6 -174 GG genotype was lower in the patients with Pathergy positivity. These results suggest that TGF-beta 1 and IL-10 gene polymorphisms may affect host susceptibility to BD. Also, to confirm the biological significance of our results, further studies should be performed on other population groups and in large number of cases.Item Efficacy of losartan in patients with primary focal segmental glomerulosclerosis resistant to immunosuppressive treatment(Wiley, 2003-03) Usta, Mehmet; Ersoy, Alparslan; Dilek, Kamil; Özdemir, Bülent; Yavuz, Mahmut; Güllülü, Mustafa; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; 7005030712; 35612977100; 56005080200; 7004168959; 7006244754; 6602684544; 7003389525Objectives. Angiotensin II may play an important role in the progression of renal disease. Currently, angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists are commonly used for renoprotection. To our knowledge, there is no study investigating this effect of angiotensin II receptor antagonists in patients with primary focal segmental glomerulosclerosis (FSGS) in the literature. The aim of this study was to evaluate the effects of losartan on proteinuria and renal function in patients with FSGS refractory to immunosuppressive treatment. Design. Twenty-three normotensive patients with FSGS proven through renal biopsy were included in the study. Thirteen of them, five men and eight women, were given losartan in a dose of 50 mg day(-1) during 12 months, and 10, four men and six women, were in the control group. Mean arterial blood pressure (MAP), 24-h urine protein excretion, serum total protein and albumin levels were determined just before the start of treatment as well as after 1, 6 and 12 months of the study. In addition, serum creatinine, creatinine clearence (CrCl), cholesterol and triglyceride levels were determined at the beginning and end of the study. Results. Age, gender and baseline levels of proteinuria, serum albumin, total protein, creatinine, CrCl and MAPs were similar in the two groups. Nephrotic range of proteinuria was present in five of 13 patients (38.4%) in the losartan group and in four of 10 patients (40%) in the control group. In the losartan group, 24-h proteinuria had decreased from 3.6 +/- 0.5 g to 2.3 +/- 0.5 g after 1 month, to 2.4 +/- 0.7 g after 6 months and to 1.9 +/- 0.7 g after 12 months. In the control group, a significant increase in proteinuria compared with the baseline value was noticed after 12 months. Proteinuria levels were significantly higher in the control group than in the losartan group after 6 and 12 months. Whilst total protein and albumin levels increased in the losartan group, they did not change significantly in the control group. The total protein levels after 6 and 12 months, and albumin levels after 6 months were significantly higher in the losartan group than in the control group. No significant change was observed between the baseline and the 12-month creatinine and CrCl levels of the groups when intra- and inter-group comparisons were made. Furthermore, serum cholesterol levels of the losartan group were reduced significantly. The changes in MAP values did not reach significant levels in either of the groups. There was no correlation between the percentage changes in MAP and in proteinuria of the losartan group after 12 months. Conclusions. Angiotensin II receptor antagonists may be an alternative therapy in FSGS patients who are resistant to immunosuppressive therapy.Item Erken evre otozomal dominant polikistik böbrek hastalığında fgf23 düzeyi ve arteryel sertlik (Stiffness) ile ilişkisi(Uludağ Üniversitesi, 2012) Yıldız, Abdülmecit; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Bilim Dalı.Otozomal Dominant Polikistik Böbrek Hastalığında (ODPBH) hastalığında en önemli mortalite nedeni kardiyovasküler (KV) hastalıklardır. ODPBH'nda KV hastalıkların etyolojisi net değildir. Kronik böbrek hastalığına sahip hastalarda ve normal popülasyonda yüksek FGF23 düzeylerinin KV hastalık riskini arttırdığı gösterilmiştir. ODPBH'nda FGF23 düzeyinin arttığı tek bir çalışmada bildirilmiştir. Çalışmamızda erken evre ODPBH'nda FGF 23 düzeyini ve arteriyel sertlik ile ilişkisini araştırmayı planladık.Böbrek fonksiyonları normal 54 (37 erkek, 17 kadın) erken evre ODPB hastası ve 26 (13 erkek, 13 kadın) sağlıklı kontrol grubu çalışmaya alındı. Tüm hastaların FGF23 düzeyi ve aplanasyon tonometri metodu ile arteriyel elastisite ölçümlerinin kantitatif analizi yapıldı.ODPBH grubunda 23 hastada hipertansiyon mevcuttu Hipertansif hastaların tamamı Renin-Anjiyotensin sistemi (RAS) blokeri kullanmaktaydı. ODPBH'nda FGF23 düzeyi sağlıklı kontrol grubu ile karşılaştırıldığında belirgin olarak yüksekti. [sırasıyla 340.2RU/ml (60.4-1770) e karşı 39.8RU/ml (4-82.6) P < 0.001]. Kalsiyum, fosfor D vitamini ve PTH düzeyleri arasında fark yoktu. Büyük (C1) ve küçük (C2) arter elastisitesi ODPBH'nda kontrol grubu ile karşılaştırıldığında belirgin olarak düşüktü. Hipertansif olmayan ODPBH'nda (n=31) küçük arter (C2) elastisitesi sağlıklı kontrol grubuna göre belirgin olarak düşüktü (p değeri 0.004). Hipertansif ODPBH'nda (n=23) ve kontrol grubunda elastisite ölçümleri benzerdi (p değeri 0.241). Arteriyel elastisite ölçümleri (C1, C2) ile FGF23 düzeyleri arasında korelasyon bulunmadı.Çalışmamızda erken evre ODPB hastalarında FGF23 düzeyinin arteriyel sertlikle birlikte belirgin olarak arttığı gösterildi. Ayrıca RAS blokerlerinin ODPBH'nda arteriyel sertlik üzerinde olumlu etkileri olabilir. Daha büyük çalışmalarla ODPB hastalığında FGF23 artışının nedenleri ve bu hasta grubunda KV etkileri araştırılmalıdır.Item IL-1 cluster gene polymorphisms in Turkish patients with Behçet's disease(Wiley, 2011-08) Özçimen, Ahmet Ata; Dilek, Kamil; Bingöl, Ümit; Sarıcaoğlu, Hayriye; Sarandöl, Aslı; Taşkapılıoğlu, Özlem; Yurtkuran, Merih M.; Yurtkuran, Mustafa Abbas; Oral, Haluk Barbaros; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji ve Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; 0000-0003-0463-6818; 0000-0003-4436-3797; AAK-6623-2020; K-7285-2012; X-4479-2018; 56005080200; 6507727900; 6603722836; 14020405100; 23037226400; 55408539300; 7003389525; 7004498001Several cytokine genes may play crucial roles in host susceptibility to Behcet's Disease (BD), since the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphisms. The association of the IL-1 cluster gene polymorphisms with the development of BD was investigated in this study. DNA samples were obtained from a Turkish population of 97 patients with BD, and 77 healthy control subjects. All genotyping (IL-1 alpha, IL-1 beta, IL-1R and IL-1Ra) experiments were performed using sequence specific primers PCR (PCR-SSP). When compared to the healthy controls, the frequencies of IL-1Ra IL-1 alpha and IL-1R gene polymorphisms were not significantly different in BD patients. The frequency of IL-1 beta -511 TT genotype was higher in the BD group in comparison to the control group. Interestingly, we demonstrated that IL-1 beta +3962 gene polymorphism seems to be associated with the presence of Erythema nodosum in BD patients. Our data suggest that polymorphisms in IL-1 beta gene may affect host susceptibility to BD. In order to confirm the biological significance of our results, further studies should be performed in a large-scale study and/or in different ethnic groups.Item Interleukin-2 gene polymorphism in Turkish patients with Behcet's disease and its association with ocular involvement(Wiley, 2013-10) Özçimen, Ahmet Ata; Yücel, Ali; Dilek, Kamil; Saba, Davit; Yurtkuran, Mustafa Abbas; Oral, Haluk Barbaros; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji ve Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; 0000-0003-0463-6818; K-7285-2012; 57225839918; 56005080200; 55987378200; 7003389525; 7004498001Behcet's disease (BD) is a chronic immune-mediated systemic disease, characterized by oral and genital lesions and ocular inflammation. Several cytokine genes may play crucial roles in host susceptibility to BD, because the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphisms. The association of the interleukin (IL)-2 gene polymorphisms with the susceptibility to BD was investigated in this study. DNA samples were obtained from a Turkish population of 97 patients with BD and 76 healthy control subjects. Polymorphisms of IL-2 gene at position -330 and +166 were determined using the polymerase chain reaction with sequence-specific primers. In the patients with BD, there was a significantly increased frequency of IL-2 -330 GT genotype. Interestingly, we demonstrated that the frequencies of IL-2 -330 GT and IL-2+166 GG genotypes were increased in BD patients with ocular involvement, whilst IL-2 -330 TT genotype was significantly decreased. Also, analysis of allele frequency demonstrated that the presence of G allele at position +166 of IL-2 seems to be a risk factor for ocular involvement. These results reveal that IL-2 -330 GT genotype may be a susceptibility factor for BD, whereas IL-2 -330 TT genotype seems to display a protective association with BD. Additionally, IL-2 gene polymorphisms might be associated with ocular involvement in BD.Item Interleukin-2 gene polymorphism in Turkish patients with Behcet's disease and its association with ocular involvement(Wiley, 2012-09) Özçimen, Ahmet Ata; Yücel, Ali; Dilek, Kamil; Saba, Davit; Sarıcaoğlu, Hayriye; Yurtkuran, Mustafa Abbas; Oral, Haluk Barbaros; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; 0000-0003-0463-6818; K-7285-2012Item Interleukin-4 gene polymorphisms confer Behcet's disease in Turkish population(Wiley, 2011-06) Özçimen, Ahmet Ata; Oral, Haluk Barbaros; Dilek, Kamil; Taşkapılıoğlu, Özlem; Bingöl, Ümit; Sarandöl, Aslı; Sarıcaoğlu, Hayriye; Yurtkuran, Merih M.; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji ve Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; 0000-0003-0463-6818; K-7285-2012; 7004498001; 56005080200; 23037226400; 6507727900; 14020405100; 6603722836; 55408539300; 7003389525Several cytokine genes may play crucial roles in host susceptibility to Behcet's Disease (BD), because the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphisms. The association of the IL-4 and IL-4R alpha gene polymorphisms with the susceptibility to BD was investigated in this study. DNA samples were obtained from a Turkish population of 97 patients with BD and 76 healthy control subjects. All genotyping (IL-4 and IL-4R alpha) experiments were performed using PCR sequence-specific primers. When compared with the healthy controls, the frequency of IL-4 -1098 TG and -590 CT genotypes was higher in the patients with BD. Analysis of allele frequencies showed that IL-4 -1098 G and IL-4 -590 T alleles were more common in the patients with BD when compared with healthy controls. Also, IL-4 TTC and haplotypes were found to confer BD. Interestingly, we demonstrated that IL-4R alpha gene polymorphism seems to be associated with the Pathergy test positivity in patients with BD. Our data suggest that IL-4 gene promoter polymorphisms may affect susceptibility to BD and increase risk of developing the disease. However, in order to confirm and assess the association of IL-4 and IL-4R alpha gene polymorphisms with the BD, large cohort studies are needed.Item Ki-67 proliferation index in renal biopsy samples of patients with systemic lupus erythematosus and its correlation with clinical findings(Iranian Soc Nephrolgy, 2013-05) Dalkılıç, Ediz; Filiz, Gülaydan; Yavuz, Mahmut; Dilek, Kamil; Ersoy, Alparslan; Yurtkuran, Mustafa Abbas; Oruç, Ayşegül; Gül, Cuma Bülent; Güllülü, Mustafa; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Romatoloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Ana Bilim Dalı/Nefroloji Bilim Dalı.; 0000-0002-0710-0923; 0000-0003-2467-9356; 0000-0002-0342-9692; AAH-5054-2021; A-7063-2018; AAH-4002-2021; JHC-5173-2023; EVQ-8652-2022; EHM-7377-2022; EUF-5229-2022; EGT-2006-2022; JGS-9425-2023; 6506739457; 6602693514; 7006244754; 56005080200; 35612977100; 7003389525; 55133912100; 23988796000; 6602684544Introduction. Systemic lupus erythematosus is an autoimmune disease that may affect almost all organ systems. Renal involvement is the most significant prognostic factor. Renal biopsy findings play an important role in treatment decision. Ki-67 is a monoclonal antibody that is only found in proliferative cells. This study aimed to investigate the proliferative activity in renal biopsy specimens of patients with lupus nephritis using the Ki-67 monoclonal antibody, and to compare the proliferative index between different subgroups of patients. Materials and Methods. Renal biopsy specimens of 29 patients with systemic lupus erythematosus were retrospectively evaluated. Type of lupus nephritis and activity and chronicity indexes were determined. Ki-67 immunostaining was performed. For each patient, 1000 cells were counted and the number of Ki-67 positive cells was determined. The Ki-67 activity index was compared between different subgroups of lupus nephritis and correlated with systemic lupus erythematosus disease activity index, serum creatinine, proteinuria, anticardiolipin antibodies, and complement levels. Results. A positive correlation between Ki-67 proliferation index, serum creatinine levels, and systemic lupus erythematosus disease activity index were found. Although conventional activity indexes were low, in 3 of 9 patients with class II lupus nephritis, Ki-67 proliferation indexes were high, indicating proliferation. Conclusions. Ki-67 can be used as a proliferation marker in renal biopsy specimens for patients diagnosed with systemic lupus erythematosus.Item Long-term effects of losartan on proteinuria and renal function in patients with renal amyloidosis(Informa Healthcare, 2002) Dilek, Kamil; Usta, Mehmet; Ersoy, Alparslan; Yavuz, Mahmut; Güllülü, Mustafa; Yurtkuran, Mustafa Abbas; Özdemir, Binnaz Handan; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-7528-3557; 0000-0002-0710-0923; X-8540-2019; AAH-5054-2021; 56005080200; 7005030712; 35612977100; 7004168959; 7006244754; 6602684544; 7003389525Objective: To investigate the effect of the angiotensin II receptor antagonist losartan oil proteinuria in secondary amyloidosis cases. Material and Methods: Sixteen patients with renal biopsy-proven AA amyloidosis with proteinuria were included in the study. All the patients had received colchicine treatment for at least 18 months. The patients were divided into two groups with similar age and gender distributions. Eight patients were given losartan at a dose of 50 mg/day for 12 months and the other 8 patients served as controls. Mean arterial blood pressure, proteinuria, serum albumin level and renal function were determined at the initiation of the study and after 1 and 12 months. Results: There were no significant differences in proteinuria, serum albumin level, renal function or mean arterial blood pressure at the initiation of the study. In the losartan group daily proteinuria decreased significantly from 5.2 +/- 0.7 at the initiation of the study to 3.9 +/- 1.2 g at 1 month and 3.6 +/- 0.8 g at 12 months, while in the control group it changed from 4.6 +/- 1.0 to 4.7 +/- 1.0 g and 6.1 +/- 1.2 g, respectively. The increment at 12 months was significant. After 12 months of treatment with losartan, proteinuria was significantly lower in comparison to the degree of proteinuria in the control group. Serum albumin level increased significantly in the losartan group but was unchanged in the control group. In the control group, creatinine clearance showed a significant decrease. There was no significant difference in mean arterial blood pressure measurements, serum creatinine levels, total protein, albumin and creatinine clearance levels between the two groups. Conclusions: Losartan seemed to prevent an increase in proteinuria without altering the creatinine clearance level in patients with amyloidosis type AA during a 12-month period. This indicates that losartan may be used to decrease proteinuria in this patient group. However, our results are only preliminary and need to be confirmed by larger studies.Item A modified yoga-based exercise program in hemodialysis patients: A randomized controlled study(Churchill Livingstone, 2007-09) Yurtkuran, Merih; Alp, Alev; Yurtkuran, Mustafa Abbas; Dilek, Kevser; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; ABG-2019-2020; 55408539300; 56256023200; 6603823242Aim: To evaluate the effects of a yoga-based exercise program on pain, fatigue, steep disturbance, and biochemical markers in hemodialysis patients. Materials and methods: In 2004 a randomized controlled trial was carried out in the outpatient hemodialysis unit of the Nephrology Department, Uludag University Faculty of Medicine. Clinically stable hemodialysis patients (n = 37) were included and followed in two groups: the modified yoga-based exercise group (n = 19) and the control group (n = 18). Yoga-based exercises were done in groups for 30 min/day twice a week for 3 months. All of the patients in the yoga and control groups were given an active range of motion exercises to do for 10 min at home. The main outcome measures were pain intensity (measured by the visual analogue scale, VAS), fatigue (VAS), steep disturbance (VAS), and grip strength (mmHg); biochemical variables - urea, creatinine, calcium, alkaline phosphatase, phosphorus, cholesterol, HDL-cholesterol, triglyceride, erythrocyte, hematocrit - were evaluated. Results: After a 12-week intervention, significant improvements were seen in the variables: pain -37%, fatigue -55%, steep disturbance -25%, grip strength +15%, urea -29%, creatinine -14%, alkaline phosphatase -15%, cholesterol -15%, erythrocyte +11%, and hematocrit count +13%; no side-effects were seen. Improvement of the variables in the yoga-based exercise program was found to be superior to that in the control group for all the variables except calcium, phosphorus, HDL-cholesterol and triglyceride levels. Conclusion: A simplified yoga-based rehabilitation program is a complementary, safe and effective clinical treatment modality in patients with end-stage renal disease.Item Prevalence of transfusion-transmitted virus (TTV) in patients with primary glomerulopathies(Dustri Verlag, 2001-04) Usta, Mehmet; Dilek, Kevser; Dalkılıç, Ediz; Güllülü, Mustafa; Mıstık, R.; Yavuz, Mahmut; Ersoy, Alparslan; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; 7005030712; 56005080200; 6506739457; 6602684544; 6504789868; 7006244754; 35612977100; 7003389525Item The process from symptom onset to rheumatology clinic in polymyalgia rheumatica(Springer Heidelberg, 2014-04-24) Tufan, Fatih; Dalkılıç, Ediz; Tufan, Ayşe Nur; Hafızoğlu, Emre; Hafızoğlu, Merve; Öksüz, Ferhat; Pehlıvan, Yavuz; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; AAG-8227-2021; 6506739457; 56076552900; 56182528900; 56182827600; 56182723600; 13205593600; 7003389525Polymyalgia rheumatica (PMR) is an inflammatory disease of individuals aged over 50 years. Because of the concomitant malignancy possibility and the high prevalence of constitutional symptoms seen in this condition, patients with classical clinical picture often experience delay in diagnosis and treatment and are exposed to a wide list of laboratory and imaging procedures. In this study, we aimed to explore the adventure these patients experience from symptom onset to rheumatology clinic. A total of 106 PMR patients (84 women, 22 men) mean age 70.1 +/- A 8 were analyzed retrospectively. The time period from the onset of symptoms and referral to rheumatology specialists was explored. Diagnostic methods applied to these patients, antibiotic use and hospitalization during this period were recorded. The interval between the onset of the symptoms and admission to rheumatology unit was 13 +/- A 13 months. In this period, abdominal computed tomography (29.2 %), chest computed tomography (21.7 %), cranial magnetic resonance imaging (18.9 %) and whole-body scintigraphy (3.8 %) were applied to the patients. About 30 % of the patients were hospitalized for a mean period of 7 +/- A 3 days before referral to rheumatology unit, and 30 % of the patients were given antibiotics. In order to reduce the delay in the diagnosis of PMR and prevent unnecessary and expensive diagnostic methods, education of clinicians about the diagnosis of PMR may be beneficial.Item Systemic lupus erythematosus presenting as Kikuchi-Fujimoto disease(Clinical & Exper Rheumatology, 2001) Dalkılıç, Ediz; Karakoç, Yenal; Tolunay, Şahsene; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Romataloji Anabilim Dalı.Item The time course of gastric methotrexate intolerance in patients with rheumatoid arthritis and psoriatic arthritis(Taylor & Francis, 2013-05) Dalkılıç, Ediz; Şahbazlar, Mustafa; Güllülü, Mustafa; Yavuz, Mahmut; Dilek, Kamil; Ersoy, Alparslan; Özkaya, Güven; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-0710-0923; 0000-0003-0297-846X; AAH-5054-2021; A-4421-2016; 6506739457; 55260646400; 6602684544; 7006244754; 56005080200; 16316866500; 35612977100; 7003389525This study aimed to evaluate the incidence and the time course of methotrexate (MTX)-associated gastric intolerance in patients with rheumatoid arthritis and psoriatic arthritis. Four hundred twenty subjects undergoing MTX treatment for rheumatoid arthritis (n = 346) and psoriatic arthritis (n = 74) were retrospectively assessed. The incidence and time course of gastric MTX intolerance resulting in treatment discontinuation were investigated. In addition, the relations between gastric intolerance and patient characteristics, including gender, age, diagnosis, and rheumatoid factor (RF) positivity, were examined. Overall, oral MTX discontinuation rate due to gastric intolerance was 28.6 %. The time to discontinuation for oral MTX was 8.1 +/- A 11.5 months on average, with more than half of the discontinuations occurring within the first three months of treatment. Discontinuation was not associated with gender, age, diagnosis, or RF positivity. More than half of the patients that switched to a parenteral treatment regimen (52.6 %, 20/38) could tolerate the agent. Gastric MTX intolerance usually develops within the first year of treatment and presents a major obstacle to long-term treatment retention in patients with rheumatologic disease. However, parenteral MTX appears to be a good alternative for patients intolerant of oral MTX.Item Transfusion-transmitted virus infection in renal transplant recipients(Elsevier, 2002-12) Usta, Mine; Dilek, Keyser; Yavuz, M. S.; Mistik, Reşit; Heper, Yasemin; Güllülü, Mustafa; Burçin, Oktay; Ersoy, Alparslan; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; AAH-6506-2021; 7005030712; 6603823242; 35612977100; 6602564624; 6506103422; 6602684544; 7006244754; 6602172127; 7003389525The transfusion-transmitted virus (TTV) described recently was first detected in peripheral blood and liver tissue of symptomatic patients with posttransfusion hepatitis non A-G.1, 2 TTV is presumed to be an unenveloped, circular, negative stranded DNA virus containing a genome of 3852 bases. It is proposed that TTV is a member of a new virus family that infects humans, tentatively named the Circinoviridae.3 TTV infection in humans occurs worldwide, and its prevalence is regionally very different.4 It was first isolated from patients with posttransfusion hepatitis.2 Viremia may be transient or persistent, and viremic individuals are often asymptomatic. Its transmission occurs not only by blood transfusion, but also by non-parenteral infection.5 Renal transplant (RTx) recipients can be infected with TTV because of exposure to the frequent blood transfusions during hemodialysis treatments. However, not much data is available about TTV infection in renal transplant recipients.6, 7 Therefore, we investigated the prevalence of TTV and the relation to liver diseases in these populations.